Explore $100K+ Jobs in Mississippi

Discover professional opportunities in Mississippi with salaries of $100,000 or more. Ladders features vetted roles for experienced candidates seeking senior-level careers across the Magnolia State, from Jackson and the Gulf Coast to regional business hubs.

Mississippi Careers Across Industries

High-paying opportunities may be available in healthcare, technology, manufacturing, finance, energy, engineering, and executive leadership. Job availability and requirements vary by employer, location, and experience level, so review each listing for details.

Find Opportunities by Location

Search roles in Jackson, Gulfport, Biloxi, Hattiesburg, Southaven, and other Mississippi communities. You can also consider remote and hybrid positions with employers hiring professionals based in the state.

How to Search Mississippi Jobs on Ladders

Explore current listings, compare responsibilities and compensation details, and focus your search on roles that match your skills and career goals. Tailor your résumé to highlight measurable results, leadership experience, and relevant expertise when applying.

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1,000+

Jobs in Mississippi

Average Salary in USD

Average Salary: $111,063

Sort By: Relevance

$135K - $160K *

Join a team that's redefining data architecture by leading innovative modeling and integration initiatives. Collaborate with AI Engineers to create scalable datasets and optimize performance in a mult...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Information Technology

$103K - $172K *

Lead the charge in trading operations, providing strategic oversight and hands-on support to ensure accurate execution and compliance. Foster a collaborative team environment while managing risk and e...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Finance & Insurance

$110K - $140K *

Drive your sales career forward by leading strategic discovery conversations and developing enterprise accounts. Collaborate with technical teams to engage prospects, understand their security needs...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Information Technology

$126K - $193K *

Grow your career with a strategic partnership role focused on enterprise and public sector initiatives. Lead partner development, drive go-to-market strategies, and foster relationships to ensure succ...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$135K - $160K *

Shape the future of online payments by driving revenue growth and optimizing checkout experiences. Collaborate with sales and engineering teams to influence product strategy and enhance customer relat...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Finance & Insurance

$102K - $136K *

Empower your career by designing and delivering scalable software solutions in a dynamic environment. Collaborate with cross-functional teams to enhance healthcare supply chain products using modern t...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$130K *

Partner with us to innovate and transform Quality & Regulatory operations through technology and data analytics. Drive automation, improve efficiency, and foster effective digital solutions that enhan...

United StatesRemote

Reposted 2 weeks ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$120K - $145K *

Drive the global marketing strategy for a technology partner ecosystem, enhancing customer experiences through seamless integrations. Collaborate with cross-functional teams to create impactful go-to...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Business Services

$80K - $121K *

Elevate patient care by leading a dedicated team in delivering high-quality home health services. Oversee clinical operations, ensure compliance with care plans, and foster a supportive environment fo...

2 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$100K - $120K *

Join a team that's dedicated to leading tax processes and delivering technical expertise while mentoring staff, managing client relationships, and driving strategic growth in a collaborative environme...

United StatesRemote

Reposted 2 weeks ago

  •   5 - 7 years exp.  •   Legal & Accounting

$120K - $140K *

Drive early-stage account engagement by identifying prospects and building relationships. Leverage your SDR experience in cybersecurity to create qualified opportunities and support Sales Directors in...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Information Technology

$122K - $204K *

Lead the charge in renewing and expanding customer relationships within complex healthcare environments. Leverage your expertise in the 340B program to drive strategy, enhance partnerships, and delive...

RemoteRemote

Reposted 2 weeks ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$196K - $270K *

Empower the growth of MSSP partnerships by driving adoption, building relationships, and integrating solutions. Collaborate with partners to enhance technical offerings and ensure success through trai...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Enterprise Technology

$136K - $170K *

Drive impactful infrastructure solutions by collaborating with engineering teams to resolve blockers, execute migrations, and develop tooling. Leverage your expertise to enhance platform adoption and...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Aerospace & Defense

$189K - $222K *

Champion client success by leading post-sale operations, ensuring seamless onboarding, delivery, and retention. Drive growth through strategic account management and operational excellence while foste...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Media

$248K - $341K *

Lead the charge in building a robust notifications platform, guiding a full-stack engineering team to enhance user engagement and retention through innovative solutions and strategic collaboration acr...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$106K - $174K *

Lead the charge in enhancing business relationships with third-party partners, driving operational efficiency and sales enablement. Collaborate across teams to improve client experiences and address s...

RemoteRemote

2 weeks ago

  •   8 - 10 years exp.  •   Finance & Insurance

$102K - $122K *

Champion client partnerships by driving strategic media campaigns and fostering relationships. Leverage your expertise in DTC paid media to enhance client success and team collaboration, ensuring impa...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Manufacturing & Automotive

$155K - $175K *

Drive impactful scientific engagement by building relationships with key stakeholders, translating clinical data into actionable insights, and ensuring successful product adoption in a dynamic prelaun...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$115K - $140K *

Unlock potential by driving sales initiatives across the Pacific Northwest. Collaborate with diverse stakeholders, execute strategic plans, and maintain customer relationships while managing territory...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Manufacturing & Automotive

$180K - $200K *

Manage the campaign calendar and ensure timely launches by transforming customer requests into actionable specs. Collaborate with cross-functional teams to maintain project alignment and drive success...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$106K - $177K *

Engage with customers to quantify and communicate the value of software solutions. Collaborate with sales teams to develop business cases and conduct ROI analyses, driving customer retention and expan...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Manufacturing & Automotive

$139K - $285K *

Drive the analytics engineering team to create AI-ready data solutions, ensuring trusted access to data across the organization. Lead strategic initiatives, build self-service capabilities, and foster...

United StatesRemote

2 weeks ago

  •   11 - 15 years exp.  •   Information Technology

$125K - $250K *

Shape the future of global sales strategy by leading initiatives that drive partner growth and sales enablement. Collaborate with cross-functional teams to optimize processes, enhance capabilities, an...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Technical Services

$200K - $300K *

Shape the finance and accounting infrastructure, ensuring accurate financials and compliance. Collaborate with teams to manage bordereaux data, oversee reinsurance accounting, and establish robust fin...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Finance & Insurance

Frequently Asked Questions (FAQ)

  • What types of $100,000+ jobs can I find in Mississippi?question toggle

    Listings may include senior roles in healthcare, technology, manufacturing, finance, energy, engineering, and management. Opportunities change over time, so check current listings for available positions.

  • Which Mississippi cities have high-paying job opportunities?question toggle

    Professional opportunities may be listed in Jackson, Gulfport, Biloxi, Hattiesburg, Southaven, and other parts of the state, depending on employer hiring needs.

  • Are remote jobs available to Mississippi residents?question toggle

    Some employers offer remote or hybrid positions that may be open to Mississippi-based candidates. Review each listing to confirm location and work arrangement requirements.

  • How can I qualify for a $100,000+ job in Mississippi?question toggle

    Requirements vary by role. Employers commonly seek relevant experience, specialized skills, and a record of strong results; senior positions may also require leadership experience or advanced credentials.