Explore $100K+ Jobs in Mississippi

Discover professional opportunities in Mississippi with salaries of $100,000 or more. Ladders features vetted roles for experienced candidates seeking senior-level careers across the Magnolia State, from Jackson and the Gulf Coast to regional business hubs.

Mississippi Careers Across Industries

High-paying opportunities may be available in healthcare, technology, manufacturing, finance, energy, engineering, and executive leadership. Job availability and requirements vary by employer, location, and experience level, so review each listing for details.

Find Opportunities by Location

Search roles in Jackson, Gulfport, Biloxi, Hattiesburg, Southaven, and other Mississippi communities. You can also consider remote and hybrid positions with employers hiring professionals based in the state.

How to Search Mississippi Jobs on Ladders

Explore current listings, compare responsibilities and compensation details, and focus your search on roles that match your skills and career goals. Tailor your résumé to highlight measurable results, leadership experience, and relevant expertise when applying.

Remote
caret down
Compensation
caret down
Position Level
caret down
Time Posted
caret down
Industries
caret down
Locations
caret down
More
1
caret down
1,000+

Jobs in Mississippi

Average Salary in USD

Average Salary: $111,063

Sort By: Relevance

$180K - $200K *

Manage and execute a comprehensive IAM strategy, ensuring robust identity security across corporate and cloud environments. Lead a team to implement Zero Trust principles and enhance identity governan...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Information Technology

$160K - $200K *

Drive financial excellence as a senior leader, overseeing operations, strategy, and compliance in a dynamic nonprofit environment. Collaborate with executives to shape growth and ensure transparency a...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Education, Government & Non-Profit

$160K - $189K *

Engage with regional health plans and PBMs to drive access strategies, manage contract negotiations, and enhance patient access. Collaborate cross-functionally to optimize pharmacy benefit performance...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Finance & Insurance

$130K - $150K *

Transform financial operations by leading month-end close, mentoring staff, and enhancing accounting processes in a dynamic CPG and e-commerce environment. Drive accuracy and compliance while supporti...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Food & Beverages

$90K - $110K *

Champion quality performance initiatives by collaborating across departments to enhance healthcare outcomes through data analysis, project management, and compliance with regulatory standards, ensurin...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$110K - $130K *

Lead strategic initiatives in population health and cancer control, collaborating with multidisciplinary teams to reduce cancer disparities and enhance care access, while securing funding and mentorin...

2 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$72K - $109K *

Lead the charge in managing claims by verifying coverage, initiating customer contact, and resolving complex issues. Collaborate with legal teams and ensure compliance while mentoring junior staff and...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Finance & Insurance

$135K - $160K *

Lead the charge in defining user experience strategy, managing a multi-disciplinary design team to deliver innovative, user-centered digital products while fostering collaboration and high-impact desi...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Finance & Insurance

$92K - $166K *

Transform electric transmission design by leading a dynamic team in delivering innovative solutions for major utilities. Drive project execution, client relations, and staff development in a fast-pace...

RemoteRemote

2 weeks ago

  •   8 - 10 years exp.  •   Technical Services

$130K - $235K *

Innovate cash management strategies in a high-volume invoicing environment. Lead a dynamic team to enhance billing accuracy and efficiency, leveraging AI and automation to optimize processes and drive...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Technical Services

$130K - $160K *

Drive a structured sales strategy for the US region, achieving targets and creating pipelines through outbound prospecting and tailored solutions while engaging senior stakeholders and maintaining CRM...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Finance & Insurance

$156K - $262K *

Join a dynamic team to design and optimize scalable data pipelines and infrastructure, enabling analytics and AI-driven capabilities. Collaborate across functions to deliver high-quality data solution...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Real Estate & Construction

$135K - $227K *

Lead the strategy and execution of workforce management for customer operations, optimizing staffing and performance through data-driven insights. Collaborate with senior leaders to enhance service le...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Real Estate & Construction

$200K - $270K *

Join a team that's redefining biostatistics in clinical development. You will lead statistical strategy across multiple therapeutic areas, ensuring excellence in design, analysis, and reporting while...

RemoteRemote

2 weeks ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$120K - $140K *

Champion our account-based marketing strategy to drive engagement and revenue for high-value remodeling businesses. Collaborate with Sales to align efforts and optimize account targeting, ensuring mea...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$75K - $110K *

Elevate our Internal Audit function by conducting comprehensive audits, evaluating controls, and ensuring compliance. Collaborate across teams to enhance processes and contribute to effective governan...

RemoteRemote

2 weeks ago

  •   Less than 5 years exp.  •   Finance & Insurance

$100K - $120K *

Join a team that's driving talent acquisition for commercial roles, enabling product launches and market expansion. Collaborate with leaders to build pipelines and deliver high-quality candidates in t...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$132K - $172K *

Lead pharmacovigilance operations and safety science initiatives, ensuring compliance and quality in drug safety reporting. Oversee vendor performance, manage safety data, and contribute to regulatory...

RemoteRemote

2 weeks ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$246K - $332K *

Drive pediatric development strategy by integrating clinical insights and regulatory commitments across multiple therapeutic areas, ensuring effective execution from candidate transition to post-marke...

RemoteRemote

2 weeks ago

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

$85K - $120K *

Drive global security initiatives by leveraging hands-on technical skills in incident response and threat analysis. Collaborate with like-minded professionals to protect organizations from advanced cy...

RemoteRemote

Reposted 2 weeks ago

  •   Less than 5 years exp.  •   Information Technology

$104K - $140K *

Transform financial systems by leading a high-performing team to enhance Workday Financials, ensuring operational excellence and strategic alignment with business goals while driving continuous improv...

RemoteRemote

2 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$104K - $153K *

Champion innovative AI-driven self-service solutions, enhancing employee experiences through ServiceNow. Collaborate with teams to streamline processes, ensuring high-quality engineering from design t...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Finance & Insurance

$100K - $162K *

Drive sales growth by developing strategic business plans and forging strong customer relationships. Achieve targets through effective presentations while adhering to ethical standards and enhancing p...

RemoteRemote

Reposted 2 weeks ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$100K - $110K *

Drive critical cross-functional initiatives, bridging strategy and execution to enhance mobile and fixed video services. Lead project management, streamline operations, and deliver impactful reporting...

RemoteRemote

2 weeks ago

  •   Less than 5 years exp.  •   Telecommunications & Hardware

$207K - $290K *

Elevate your career by leading a dynamic Applied AI team, transforming innovative AI solutions into production-ready systems within a regulated financial environment, while collaborating across depart...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Finance & Insurance

Frequently Asked Questions (FAQ)

  • What types of $100,000+ jobs can I find in Mississippi?question toggle

    Listings may include senior roles in healthcare, technology, manufacturing, finance, energy, engineering, and management. Opportunities change over time, so check current listings for available positions.

  • Which Mississippi cities have high-paying job opportunities?question toggle

    Professional opportunities may be listed in Jackson, Gulfport, Biloxi, Hattiesburg, Southaven, and other parts of the state, depending on employer hiring needs.

  • Are remote jobs available to Mississippi residents?question toggle

    Some employers offer remote or hybrid positions that may be open to Mississippi-based candidates. Review each listing to confirm location and work arrangement requirements.

  • How can I qualify for a $100,000+ job in Mississippi?question toggle

    Requirements vary by role. Employers commonly seek relevant experience, specialized skills, and a record of strong results; senior positions may also require leadership experience or advanced credentials.