Discover professional opportunities in Mississippi with salaries of $100,000 or more. Ladders features vetted roles for experienced candidates seeking senior-level careers across the Magnolia State, from Jackson and the Gulf Coast to regional business hubs.
High-paying opportunities may be available in healthcare, technology, manufacturing, finance, energy, engineering, and executive leadership. Job availability and requirements vary by employer, location, and experience level, so review each listing for details.
Search roles in Jackson, Gulfport, Biloxi, Hattiesburg, Southaven, and other Mississippi communities. You can also consider remote and hybrid positions with employers hiring professionals based in the state.
Explore current listings, compare responsibilities and compensation details, and focus your search on roles that match your skills and career goals. Tailor your résumé to highlight measurable results, leadership experience, and relevant expertise when applying.
Average Salary: $111,063
Director, Identity & Access Management (IAM)
$180K - $200K *
Manage and execute a comprehensive IAM strategy, ensuring robust identity security across corporate and cloud environments. Lead a team to implement Zero Trust principles and enhance identity governan...
2 weeks ago
$160K - $200K *
Drive financial excellence as a senior leader, overseeing operations, strategy, and compliance in a dynamic nonprofit environment. Collaborate with executives to shape growth and ensure transparency a...
2 weeks ago
Regional Account Manager - Great Lakes
$160K - $189K *
Engage with regional health plans and PBMs to drive access strategies, manage contract negotiations, and enhance patient access. Collaborate cross-functionally to optimize pharmacy benefit performance...
2 weeks ago
Accounting Manager - CPG & E-Commerce
$130K - $150K *
Transform financial operations by leading month-end close, mentoring staff, and enhancing accounting processes in a dynamic CPG and e-commerce environment. Drive accuracy and compliance while supporti...
2 weeks ago
National Quality Performance Manager - HEDIS (Remote)
$90K - $110K *
Champion quality performance initiatives by collaborating across departments to enhance healthcare outcomes through data analysis, project management, and compliance with regulatory standards, ensurin...
2 weeks ago
Associate Director of Population Health and Cancer Control
$110K - $130K *
Lead strategic initiatives in population health and cancer control, collaborating with multidisciplinary teams to reduce cancer disparities and enhance care access, while securing funding and mentorin...
2 weeks ago
Senior Casualty Claims Adjuster
$72K - $109K *
Lead the charge in managing claims by verifying coverage, initiating customer contact, and resolving complex issues. Collaborate with legal teams and ensure compliance while mentoring junior staff and...
2 weeks ago
$135K - $160K *
Lead the charge in defining user experience strategy, managing a multi-disciplinary design team to deliver innovative, user-centered digital products while fostering collaboration and high-impact desi...
2 weeks ago
Lead Transmission Line Engineer
$92K - $166K *
Transform electric transmission design by leading a dynamic team in delivering innovative solutions for major utilities. Drive project execution, client relations, and staff development in a fast-pace...
2 weeks ago
Energy Cash Management Director
$130K - $235K *
Innovate cash management strategies in a high-volume invoicing environment. Lead a dynamic team to enhance billing accuracy and efficiency, leveraging AI and automation to optimize processes and drive...
2 weeks ago
$130K - $160K *
Drive a structured sales strategy for the US region, achieving targets and creating pipelines through outbound prospecting and tailored solutions while engaging senior stakeholders and maintaining CRM...
2 weeks ago
Senior Software Development Engineer - Big Data
$156K - $262K *
Join a dynamic team to design and optimize scalable data pipelines and infrastructure, enabling analytics and AI-driven capabilities. Collaborate across functions to deliver high-quality data solution...
2 weeks ago
$135K - $227K *
Lead the strategy and execution of workforce management for customer operations, optimizing staffing and performance through data-driven insights. Collaborate with senior leaders to enhance service le...
2 weeks ago
Biostatistics Director, Oncology Biosimilars- US Remote
$200K - $270K *
Join a team that's redefining biostatistics in clinical development. You will lead statistical strategy across multiple therapeutic areas, ensuring excellence in design, analysis, and reporting while...
2 weeks ago
EverPro - Senior Growth Marketing Manager - ABM (Remote, US)
$120K - $140K *
Champion our account-based marketing strategy to drive engagement and revenue for high-value remodeling businesses. Collaborate with Sales to align efforts and optimize account targeting, ensuring mea...
2 weeks ago
$75K - $110K *
Elevate our Internal Audit function by conducting comprehensive audits, evaluating controls, and ensuring compliance. Collaborate across teams to enhance processes and contribute to effective governan...
2 weeks ago
$100K - $120K *
Join a team that's driving talent acquisition for commercial roles, enabling product launches and market expansion. Collaborate with leaders to build pipelines and deliver high-quality candidates in t...
2 weeks ago
Senior Manager, Drug Safety & Pharmacovigilance
$132K - $172K *
Lead pharmacovigilance operations and safety science initiatives, ensuring compliance and quality in drug safety reporting. Oversee vendor performance, manage safety data, and contribute to regulatory...
2 weeks ago
Executive Director, Translational Medicine & Pediatric Planning
$246K - $332K *
Drive pediatric development strategy by integrating clinical insights and regulatory commitments across multiple therapeutic areas, ensuring effective execution from candidate transition to post-marke...
2 weeks ago
Analyst I, Falcon Complete GovCloud (Hybrid, St. Louis)
$85K - $120K *
Drive global security initiatives by leveraging hands-on technical skills in incident response and threat analysis. Collaborate with like-minded professionals to protect organizations from advanced cy...
Reposted 2 weeks ago
Manager, Workday Financial Systems and Innovation
$104K - $140K *
Transform financial systems by leading a high-performing team to enhance Workday Financials, ensuring operational excellence and strategic alignment with business goals while driving continuous improv...
2 weeks ago
$104K - $153K *
Champion innovative AI-driven self-service solutions, enhancing employee experiences through ServiceNow. Collaborate with teams to streamline processes, ensuring high-quality engineering from design t...
2 weeks ago
Professional (Senior) Sales Representative, Pain - Trenton, NJ
$100K - $162K *
Drive sales growth by developing strategic business plans and forging strong customer relationships. Achieve targets through effective presentations while adhering to ethical standards and enhancing p...
Reposted 2 weeks ago
Strategic Initiatives Project Manager - US Remote
$100K - $110K *
Drive critical cross-functional initiatives, bridging strategy and execution to enhance mobile and fixed video services. Lead project management, streamline operations, and deliver impactful reporting...
2 weeks ago
Director of Applied AI Engineering
$207K - $290K *
Elevate your career by leading a dynamic Applied AI team, transforming innovative AI solutions into production-ready systems within a regulated financial environment, while collaborating across depart...
2 weeks ago
What types of $100,000+ jobs can I find in Mississippi?
Listings may include senior roles in healthcare, technology, manufacturing, finance, energy, engineering, and management. Opportunities change over time, so check current listings for available positions.
Which Mississippi cities have high-paying job opportunities?
Professional opportunities may be listed in Jackson, Gulfport, Biloxi, Hattiesburg, Southaven, and other parts of the state, depending on employer hiring needs.
Are remote jobs available to Mississippi residents?
Some employers offer remote or hybrid positions that may be open to Mississippi-based candidates. Review each listing to confirm location and work arrangement requirements.
How can I qualify for a $100,000+ job in Mississippi?
Requirements vary by role. Employers commonly seek relevant experience, specialized skills, and a record of strong results; senior positions may also require leadership experience or advanced credentials.