Explore $100K+ Jobs in Mississippi

Discover professional opportunities in Mississippi with salaries of $100,000 or more. Ladders features vetted roles for experienced candidates seeking senior-level careers across the Magnolia State, from Jackson and the Gulf Coast to regional business hubs.

Mississippi Careers Across Industries

High-paying opportunities may be available in healthcare, technology, manufacturing, finance, energy, engineering, and executive leadership. Job availability and requirements vary by employer, location, and experience level, so review each listing for details.

Find Opportunities by Location

Search roles in Jackson, Gulfport, Biloxi, Hattiesburg, Southaven, and other Mississippi communities. You can also consider remote and hybrid positions with employers hiring professionals based in the state.

How to Search Mississippi Jobs on Ladders

Explore current listings, compare responsibilities and compensation details, and focus your search on roles that match your skills and career goals. Tailor your résumé to highlight measurable results, leadership experience, and relevant expertise when applying.

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1,000+

Jobs in Mississippi

Average Salary in USD

Average Salary: $110,961

Sort By: Relevance

$150K - $175K *

Shape the future of client partnerships by driving strategic growth and success for large enterprise organizations. Collaborate with cross-functional teams to deliver exceptional value and measurable...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Healthcare

$130K - $160K *

Champion the migration to a modern Databricks lakehouse, designing robust data pipelines and ensuring data quality. Collaborate with teams to enhance analytics capabilities and set technical standards...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Enterprise Technology

$110K - $130K *

Champion strategic growth by managing key accounts, fostering relationships, and driving sales initiatives. Collaborate with leadership to meet customer needs and exceed performance objectives while r...

United StatesRemote

Reposted 2 weeks ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$215K - $230K *

Transform compliance into actionable insights by bridging technical teams and auditors. Own your area of responsibility, enhance security measures, and drive automation in a multi-cloud environment wh...

United StatesRemote

2 weeks ago

  •   11 - 15 years exp.  •   Information Technology

$110K - $130K *

Join a team that's redefining organizational strategy and driving impactful solutions. As a Senior People Partner, you'll collaborate with leadership to align talent priorities with business outcomes...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Enterprise Technology

$149K - $187K *

Drive regional sales success by leading a team of Territory Sales Managers, fostering a culture of accountability and collaboration, and executing strategic initiatives to achieve performance targets...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$100K - $200K *

Join a team that's dedicated to enhancing customer success through technical expertise. You'll build strong relationships with enterprise clients, guiding them in adopting our products and ensuring th...

United StatesRemote

Reposted 2 weeks ago

  •   Less than 5 years exp.  •   Information Technology

$136K - $220K *

Unlock project management excellence in Global Regulatory Affairs, driving timelines and compliance for drug submissions. Collaborate cross-functionally to ensure accurate documentation and effective...

United StatesRemote

Reposted 2 weeks ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$90K - $110K *

Empower cross-functional teams to drive the Future of Medicine initiatives, ensuring scalable processes and compliance while enhancing patient safety and experience through strategic planning and exec...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$130K - $145K *

Champion client success by managing strategic partnerships with mid-sized enterprises. Drive measurable outcomes through relationship management, consultative problem-solving, and cross-functional col...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$117K - $130K *

Transform your career by leading strategic go-to-market initiatives for a fast-growing ELA Core Curriculum portfolio. Drive impactful messaging, cross-functional alignment, and scalable processes to e...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Education, Government & Non-Profit

$90K - $110K *

Lead the charge in ensuring compliance and integrity within federal healthcare programs through rigorous investigations, data analysis, and collaboration with key stakeholders to produce actionable fi...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Staffing

$95K - $115K *

Join a dynamic global accounting team as you manage international audits, enhance month-end close processes, and drive improvements in accounting operations. Take ownership of complex projects while c...

RemoteRemote

2 weeks ago

  •   5 - 7 years exp.  •   Enterprise Technology

$120K - $135K *

Drive operational excellence by leveraging data analysis and Lean Six Sigma methodologies. Lead initiatives that enhance performance across functions, mentor teams, and align improvements with strateg...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Energy & Utilities

$150K - $500K *

Accelerate progress at a leading pharmaceutical engagement firm by driving sales strategy and growth for a new compliance-focused product, Curated. Leverage your extensive network and expertise to bui...

RemoteRemote

2 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$156K - $247K *

Lead the charge in patient engagement strategy, optimizing support programs and enhancing the patient journey from consideration to conversion. Collaborate across teams to amplify patient voices and d...

RemoteRemote

2 weeks ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$87K - $120K *

Champion our legal team by providing expert guidance on employment and labor matters, ensuring compliance and risk management across diverse jurisdictions while collaborating with HR and business lead...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Transportation

$125K - $147K *

Join a team that's redefining revenue operations by enhancing visibility and accountability across the customer journey. Collaborate with marketing and sales to build insightful reporting and drive da...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Enterprise Technology

$120K - $145K *

Lead the charge in driving strategic sales initiatives, managing key accounts, and fostering long-term partnerships. Collaborate with cross-functional teams to identify growth opportunities and delive...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Consumer Technology

$85K *

Manage the end-to-end polling process by designing effective surveys, analyzing data, and collaborating with cross-functional teams to deliver strategic insights that inform client decisions and enhan...

RemoteRemote

Reposted 2 weeks ago

  •   Less than 5 years exp.  •   Enterprise Technology

$120K - $175K *

Unlock potential by leading AI deployments that transform customer experiences. Collaborate with cross-functional teams to ensure projects deliver real business outcomes. Take charge of planning, exec...

United StatesRemote

Reposted 2 weeks ago

  •   Less than 5 years exp.  •   Information Technology

$125K - $150K *

Shape the future of organic growth by driving strategic digital transformation across channels, improving patient access to mental healthcare through innovative marketing strategies, data-driven insig...

United StatesRemote

Reposted 2 weeks ago

  •   8 - 10 years exp.  •   Healthcare

$95K - $115K *

Transform maintenance and reliability performance in a dynamic manufacturing environment. Lead a high-performing team to enhance equipment availability, reduce downtime, and foster a culture of contin...

2 weeks ago

  •   8 - 10 years exp.  •   Manufacturing & Automotive

$110K - $120K *

Elevate talent management by executing core programs, enhancing employee experience, and driving performance initiatives. Lead cross-functional projects, ensuring accountability and operational contin...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Information Technology

$135K - $155K *

Drive innovation as you develop and deploy cutting-edge AI solutions that enhance advertising measurement products, collaborating with cross-functional teams to maximize ROI and shape technology at sc...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Media

Frequently Asked Questions (FAQ)

  • What types of $100,000+ jobs can I find in Mississippi?question toggle

    Listings may include senior roles in healthcare, technology, manufacturing, finance, energy, engineering, and management. Opportunities change over time, so check current listings for available positions.

  • Which Mississippi cities have high-paying job opportunities?question toggle

    Professional opportunities may be listed in Jackson, Gulfport, Biloxi, Hattiesburg, Southaven, and other parts of the state, depending on employer hiring needs.

  • Are remote jobs available to Mississippi residents?question toggle

    Some employers offer remote or hybrid positions that may be open to Mississippi-based candidates. Review each listing to confirm location and work arrangement requirements.

  • How can I qualify for a $100,000+ job in Mississippi?question toggle

    Requirements vary by role. Employers commonly seek relevant experience, specialized skills, and a record of strong results; senior positions may also require leadership experience or advanced credentials.