Explore $100K+ Jobs in Mississippi

Discover professional opportunities in Mississippi with salaries of $100,000 or more. Ladders features vetted roles for experienced candidates seeking senior-level careers across the Magnolia State, from Jackson and the Gulf Coast to regional business hubs.

Mississippi Careers Across Industries

High-paying opportunities may be available in healthcare, technology, manufacturing, finance, energy, engineering, and executive leadership. Job availability and requirements vary by employer, location, and experience level, so review each listing for details.

Find Opportunities by Location

Search roles in Jackson, Gulfport, Biloxi, Hattiesburg, Southaven, and other Mississippi communities. You can also consider remote and hybrid positions with employers hiring professionals based in the state.

How to Search Mississippi Jobs on Ladders

Explore current listings, compare responsibilities and compensation details, and focus your search on roles that match your skills and career goals. Tailor your résumé to highlight measurable results, leadership experience, and relevant expertise when applying.

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1,000+

Jobs in Mississippi

Average Salary in USD

Average Salary: $110,961

Sort By: Relevance

$80K - $95K *

Advance your career as a Telehealth Clinical Supervisor, providing leadership and clinical oversight to therapists delivering IOP-level care. Collaborate with a dedicated team to enhance patient outco...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Hospitals & Medical Centers

$90K - $110K *

Unlock potential by driving business development initiatives in renewable energy. Collaborate with teams to identify opportunities, build customer relationships, and support proposal development for b...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Energy & Utilities

$135K - $160K *

Lead and optimize PMO strategies for major aviation and infrastructure programs. Drive governance, risk management, and stakeholder engagement while mentoring a high-performing team to ensure project...

United StatesRemote

2 weeks ago

  •   11 - 15 years exp.  •   Real Estate & Construction

$198K - $297K *

Join us to lead the design and evolution of a cutting-edge Real-Time Analytics Platform, driving high-throughput, low-latency data solutions. Collaborate with cross-functional teams to enhance scalabi...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Consumer Technology

$100K *

Partner with us to defend individual liberties and combat government overreach. Engage in impactful public-interest law through a year-long fellowship, honing your legal skills alongside seasoned prof...

United StatesRemote

Reposted 2 weeks ago

  •   Less than 5 years exp.  •   Legal & Accounting

$288K - $500K+*

Drive new business growth and foster strategic partnerships within Federal Healthcare Agencies, leveraging expertise in Veeam solutions and deep understanding of market dynamics to enhance client rela...

United StatesRemote

Reposted 2 weeks ago

  •   5 - 7 years exp.  •   Enterprise Technology

$125K - $150K *

Engineer scalable Azure data solutions, leading architecture and modernization initiatives. Collaborate with teams to define standards and ensure high-performance data integration, governance, and sec...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$216K - $318K *

Drive innovation as you lead engineering teams to build and scale Life360's critical platforms. Ensure reliability and security while fostering a culture of accountability and technical excellence for...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Information Technology

$170K - $187K *

Join a team that's shaping the future of Enterprise Architecture by driving innovative solutions and strategic design for hybrid banking systems. Collaborate across diverse teams to create scalable, f...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Legal & Accounting

$110K - $130K *

Shape the future of customer experiences by leading product strategy and backlog management. Collaborate cross-functionally to drive growth in small commercial insurance, leveraging data and insights...

RemoteRemote

2 weeks ago

  •   5 - 7 years exp.  •   Finance & Insurance

$108K - $130K *

Unlock your potential by leading customer projects, ensuring seamless communication, and driving success in healthcare solutions. Collaborate with diverse teams to enhance client satisfaction and oper...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$114K - $135K *

Transform event experiences by leading strategy and execution for high-impact trade shows and corporate events. Collaborate cross-functionally to drive brand awareness and measurable business impact i...

United StatesRemote

Reposted 2 weeks ago

  •   8 - 10 years exp.  •   Enterprise Technology

$120K - $145K *

Elevate healthcare reimbursement processes by leading legal strategies on billing disputes and regulatory compliance. Collaborate with teams to create innovative solutions and build legal frameworks t...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$114K - $140K *

Pioneer innovative solutions as a Data Scientist, driving advanced analytics and machine learning applications to enhance project success and economic opportunities across diverse teams and workflows...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Education, Government & Non-Profit

$230K - $310K *

Shape the future of global employment law by providing strategic counsel to HR and Talent teams. Guide regulatory compliance, develop jurisdiction-specific policies, and manage employment disputes whi...

United StatesRemote

2 weeks ago

  •   11 - 15 years exp.  •   Finance & Insurance

$138K - $165K *

Transform the future of pharmacy operations by leading the development of scalable, reliable front-end solutions. Collaborate with cross-functional teams to enhance user experiences and drive technica...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Healthcare

$169K - $212K *

Transform the lending landscape by driving sales of capital products to high-growth brands. Leverage your expertise to build relationships, manage complex deals, and deliver tailored credit solutions...

RemoteRemote

2 weeks ago

  •   Less than 5 years exp.  •   Finance & Insurance

$166K - $249K *

Lead the charge in building and mentoring a regional team of product SMEs, driving technical wins across diverse product groups while collaborating with sales leadership to optimize engagement and enh...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$110K - $130K *

Join a team that empowers customers to achieve their business goals through strategic guidance and hands-on support, enhancing their experience with our DevSecOps platform and driving long-term succes...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Information Technology

$157K - $205K *

Drive product strategy and execution, ensuring alignment with business goals. Collaborate across teams to oversee the full product lifecycle from ideation to market launch, optimizing for profitabilit...

United StatesRemote

Reposted 2 weeks ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$145K - $175K *

Champion the integration of AI-powered API services, ensuring reliability and scalability while bridging traditional systems with modern language models. Drive innovation in backend workflows and coll...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$146K - $182K *

Design and deliver impactful training programs to enhance sales capabilities, ensuring alignment with corporate objectives. Collaborate with cross-functional teams to drive effective onboarding and co...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$100K - $120K *

Transform claims operations by establishing efficient processes and controls. Lead end-to-end claims management, ensuring timely communication and resolution across stakeholders in a dynamic reinsuran...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Finance & Insurance

$118K - $147K *

Drive high-stakes architectural design for complex technology projects, ensuring innovative solutions from concept through execution while collaborating with leading global firms in a multidisciplinar...

United StatesRemote

Reposted 2 weeks ago

  •   15+ years exp.  •   Manufacturing & Automotive

$140K - $160K *

Shape the future of our IT landscape by managing operations, optimizing infrastructure, and leading a talented team. Drive strategic improvements while ensuring security and service excellence in a dy...

United StatesRemote

Reposted 2 weeks ago

  •   5 - 7 years exp.  •   Energy & Utilities

Frequently Asked Questions (FAQ)

  • What types of $100,000+ jobs can I find in Mississippi?question toggle

    Listings may include senior roles in healthcare, technology, manufacturing, finance, energy, engineering, and management. Opportunities change over time, so check current listings for available positions.

  • Which Mississippi cities have high-paying job opportunities?question toggle

    Professional opportunities may be listed in Jackson, Gulfport, Biloxi, Hattiesburg, Southaven, and other parts of the state, depending on employer hiring needs.

  • Are remote jobs available to Mississippi residents?question toggle

    Some employers offer remote or hybrid positions that may be open to Mississippi-based candidates. Review each listing to confirm location and work arrangement requirements.

  • How can I qualify for a $100,000+ job in Mississippi?question toggle

    Requirements vary by role. Employers commonly seek relevant experience, specialized skills, and a record of strong results; senior positions may also require leadership experience or advanced credentials.