Explore $100K+ Jobs in Mississippi

Discover professional opportunities in Mississippi with salaries of $100,000 or more. Ladders features vetted roles for experienced candidates seeking senior-level careers across the Magnolia State, from Jackson and the Gulf Coast to regional business hubs.

Mississippi Careers Across Industries

High-paying opportunities may be available in healthcare, technology, manufacturing, finance, energy, engineering, and executive leadership. Job availability and requirements vary by employer, location, and experience level, so review each listing for details.

Find Opportunities by Location

Search roles in Jackson, Gulfport, Biloxi, Hattiesburg, Southaven, and other Mississippi communities. You can also consider remote and hybrid positions with employers hiring professionals based in the state.

How to Search Mississippi Jobs on Ladders

Explore current listings, compare responsibilities and compensation details, and focus your search on roles that match your skills and career goals. Tailor your résumé to highlight measurable results, leadership experience, and relevant expertise when applying.

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1,000+

Jobs in Mississippi

Average Salary in USD

Average Salary: $110,961

Sort By: Relevance

$135K - $159K *

Unlock potential by driving client outreach and proposals, converting new partners to the platform. Own complex sales cycles, build executive relationships, and leverage AI-driven strategies to enhanc...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Technical Services

$115K - $194K *

Unlock your potential as a strategic partner to senior Engineering leaders, driving organizational change and fostering a high-performance culture across global teams in a fast-paced tech environment...

RemoteRemote

2 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$350K *

Join a team that's redefining enterprise sales by driving strategic growth and building executive relationships with Fortune 1000 companies. You'll lead complex deals and shape our sales playbook in a...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$82K - $128K *

Shape data-driven strategies by developing and automating analytics solutions. Collaborate with cross-functional teams to enhance reporting capabilities and optimize operational performance in a dynam...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$172K - $229K *

Lead the charge in developing advanced motion planning algorithms for autonomous vehicles, ensuring safety and performance through rigorous design, testing, and cross-functional collaboration in dynam...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Transportation

$95K - $115K *

Engage in diverse remediation projects, leading design and implementation efforts while ensuring project success through effective management and client engagement in a collaborative environment...

United StatesRemote

Reposted 2 weeks ago

  •   8 - 10 years exp.  •   Technical Services

$110K - $130K *

Unlock potential by joining a dynamic team of actuaries focused on managing and optimizing defined benefit pension plans, ensuring compliance, and delivering accurate valuations in a fully remote envi...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Finance & Insurance

$100K - $120K *

Champion ecosystem partnerships by managing relationships, driving co-selling efforts, and executing joint go-to-market strategies. Collaborate cross-functionally to ensure successful integration and...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Enterprise Technology

$187K - $257K *

Elevate global sales operations by leading forecasting, pipeline management, and productivity initiatives. Collaborate with sales leaders to enhance clarity and consistency, driving growth through inn...

RemoteRemote

2 weeks ago

  •   8 - 10 years exp.  •   Information Technology

$94K - $141K *

Shape the future of software delivery by crafting compelling messaging and positioning for regulated enterprises. Drive executive conversations with insights on compliance and AI governance, while equ...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Enterprise Technology

$185K - $230K *

Unlock potential by developing strategic access plans for community healthcare, ensuring streamlined reimbursement processes and compliance while collaborating with stakeholders to enhance patient acc...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$198K - $233K *

Architect the roadmap for our Business Technology Services and Workato platform, driving integration and automation across systems. Collaborate with stakeholders to prioritize demands, ensuring scalab...

United StatesRemote

Reposted 2 weeks ago

  •   8 - 10 years exp.  •   Consumer Technology

$198K - $233K *

Lead the charge in developing a robust content management system to enhance cross-functional workflows and publishing capabilities, fostering a high-performing engineering team dedicated to scalabilit...

United StatesRemote

Reposted 2 weeks ago

  •   8 - 10 years exp.  •   Consumer Technology

$110K - $130K *

Accelerate your career by leading cross-functional programs that drive strategic initiatives in healthcare and biotechnology. Leverage your expertise to enhance product development, compliance, and op...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Healthcare

$80K - $95K *

Empower the clinical support team by coordinating complex cases, mentoring junior counselors, and enhancing protocols. Your expertise will drive effective communication and quality standards in geneti...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$171K - $269K *

Lead the charge in defining and evolving data architecture and engineering standards for scalable, secure enterprise data platforms. Collaborate across teams to deliver reliable, actionable data produ...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Information Technology

$150K - $170K *

Join us to bridge technology and clients in the mortgage industry. You'll engage directly with customers, develop solutions, and influence product direction while driving efficiency and innovation in...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Finance & Insurance

$120K - $140K *

Architect AI-driven solutions to enhance GTM operations, streamline workflows, and empower sales and support teams. Collaborate cross-functionally to automate processes, improve efficiency, and drive...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Education, Government & Non-Profit

$170K - $185K *

Champion technical sales execution across diverse domains, driving alignment with growth priorities. Lead a high-performing team, enhance customer outcomes, and provide strategic insights to elevate s...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Information Technology

$200K - $230K *

Unlock the potential of innovative products by partnering with technical teams to design and deliver exceptional customer experiences in a dynamic, regulated environment. Your expertise will shape com...

United StatesRemote

Reposted 2 weeks ago

  •   8 - 10 years exp.  •   Finance & Insurance

$80K - $95K *

Transform patient care by leading nursing initiatives, enhancing service delivery, and fostering collaboration across departments. Drive efficiency and satisfaction through strategic oversight and inn...

2 weeks ago

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$150K - $180K *

Champion enterprise systems diligence and value creation engagements, assessing technology, processes, and infrastructure to drive operational excellence and strategic insights for investors and manag...

United StatesRemote

2 weeks ago

  •   11 - 15 years exp.  •   Information Technology

$110K - $130K *

Champion innovative paid marketing strategies to drive growth, manage budgets, and optimize performance across channels. Collaborate with teams to connect efforts and achieve measurable results in use...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Enterprise Technology

$68K - $113K *

Empower your career as a key partner to technology leaders, managing complex calendars, coordinating meetings, and crafting impactful presentations. Join a dynamic team dedicated to enhancing organiza...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Finance & Insurance

$120K - $145K *

Transform client engagements by leading functional solution design for Salesforce Marketing Cloud Next, integrating marketing strategy with data architecture to optimize multi-channel campaigns and en...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Information Technology

Frequently Asked Questions (FAQ)

  • What types of $100,000+ jobs can I find in Mississippi?question toggle

    Listings may include senior roles in healthcare, technology, manufacturing, finance, energy, engineering, and management. Opportunities change over time, so check current listings for available positions.

  • Which Mississippi cities have high-paying job opportunities?question toggle

    Professional opportunities may be listed in Jackson, Gulfport, Biloxi, Hattiesburg, Southaven, and other parts of the state, depending on employer hiring needs.

  • Are remote jobs available to Mississippi residents?question toggle

    Some employers offer remote or hybrid positions that may be open to Mississippi-based candidates. Review each listing to confirm location and work arrangement requirements.

  • How can I qualify for a $100,000+ job in Mississippi?question toggle

    Requirements vary by role. Employers commonly seek relevant experience, specialized skills, and a record of strong results; senior positions may also require leadership experience or advanced credentials.