Explore $100K+ Jobs in Mississippi

Discover professional opportunities in Mississippi with salaries of $100,000 or more. Ladders features vetted roles for experienced candidates seeking senior-level careers across the Magnolia State, from Jackson and the Gulf Coast to regional business hubs.

Mississippi Careers Across Industries

High-paying opportunities may be available in healthcare, technology, manufacturing, finance, energy, engineering, and executive leadership. Job availability and requirements vary by employer, location, and experience level, so review each listing for details.

Find Opportunities by Location

Search roles in Jackson, Gulfport, Biloxi, Hattiesburg, Southaven, and other Mississippi communities. You can also consider remote and hybrid positions with employers hiring professionals based in the state.

How to Search Mississippi Jobs on Ladders

Explore current listings, compare responsibilities and compensation details, and focus your search on roles that match your skills and career goals. Tailor your résumé to highlight measurable results, leadership experience, and relevant expertise when applying.

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1,000+

Jobs in Mississippi

Average Salary in USD

Average Salary: $110,961

Sort By: Relevance

$120K - $145K *

Elevate technical solutions by designing, building, and supporting Dynamics 365 Finance & Supply Chain Management components. Collaborate with teams to deliver high-quality, maintainable solutions whi...

RemoteRemote

1 week ago

  •   5 - 7 years exp.  •   Business Services

$175K - $250K *

Drive the development of innovative reinsurance strategies and statutory capital optimization. Lead cross-functional teams to enhance corporate solvency and risk-adjusted returns while managing regula...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Healthcare

$175K - $250K *

Unlock potential by leading pricing strategy and actuarial modeling for Commercial lines, ensuring regulatory compliance and operational excellence while collaborating across teams to drive profitable...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Healthcare

$175K - $250K *

Shape the future of Medicare Advantage bidding by leading strategy, modeling, and execution. Collaborate across teams to ensure compliance and drive successful outcomes in a fast-paced environment...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Healthcare

$110K - $130K *

Develop technical requirements for utility-scale battery energy storage systems. Collaborate with engineering teams to ensure compliance with industry standards and project specifications while drivin...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Energy & Utilities

$92K - $116K *

Lead and inspire a team of Client Service Managers to elevate client satisfaction, driving operational excellence while managing strategic service delivery and fostering strong client relationships fo...

United StatesRemote

Reposted 1 week ago

  •   Less than 5 years exp.  •   Finance & Insurance

$122K - $177K *

Lead coding operations and education initiatives to ensure compliance, accuracy, and optimal reimbursement across the organization. Manage staff training and oversee coding standards while collaborati...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Healthcare

$181K - $241K *

Take ownership of enterprise-wide risk management strategies, guiding executive leadership in navigating operational, financial, and construction risks. Collaborate across functions to enhance risk pr...

RemoteRemote

1 week ago

  •   11 - 15 years exp.  •   Energy & Utilities

$94K - $193K *

Partner with us to enhance supplier quality through risk management, evaluation, and compliance. This remote role requires extensive travel, focusing on supplier performance and quality assurance acro...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Aerospace & Defense

$128K - $176K *

Take ownership of scientific partnerships with healthcare professionals, driving evidence generation and strategic initiatives. Collaborate across teams to enhance patient care and strengthen scientif...

RemoteRemote

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$75K - $158K *

Lead the charge in engineering and implementing a robust Intune solution for enterprise endpoint management, ensuring seamless integration and security across diverse devices within a mission-critical...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Information Technology

$75K - $158K *

Engage your expertise as a hands-on technical leader, designing and evolving enterprise solutions. Collaborate with cross-functional teams to drive innovation, ensure platform reliability, and deliver...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Information Technology

$149K - $171K *

Shape the future of business strategy by leveraging analytics to drive growth and profitability. Collaborate with cross-functional teams to develop innovative solutions and lead a high-performing team...

RemoteRemote

1 week ago

  •   Less than 5 years exp.  •   Finance & Insurance

$179K - $204K *

Champion innovative security solutions by designing automated controls and cloud architectures. Collaborate with cross-functional teams to enhance enterprise security and drive technical transformatio...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Finance & Insurance

$90K - $110K *

Shape the future of recruitment by building a market strategy, developing client relationships, and managing the full recruitment lifecycle to drive success and revenue growth in a dynamic environment...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Staffing

$145K *

Drive innovation and transform lives by leading regulatory strategies and submissions for clinical trials globally. Act as a key liaison for project teams to ensure compliance, operational excellence...

United StatesRemote

Reposted 1 week ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$110K - $150K *

Empower our brands by owning and executing a dynamic organic social media strategy. Collaborate across teams to create engaging content, drive audience growth, and measure impact, while ensuring brand...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Enterprise Technology

$150K - $175K *

Elevate your career by leading a high-performing Security Engineering and CloudSecOps team. Drive security initiatives across cloud and enterprise environments, ensuring compliance and resilience whil...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Healthcare

$82K - $110K *

Champion grant proposal excellence by collaborating with clients to enhance competitiveness in scientific research funding. Drive impactful outcomes through expert consulting, training, and proposal d...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Business Services

$134K - $205K *

Lead the charge in ensuring quality standards for heavy industrial construction projects. Oversee QA/QC processes, conduct audits, and support contractors to enhance performance and safety throughout...

United StatesRemote

1 week ago

  •   11 - 15 years exp.  •   Technical Services

$100K - $130K *

Elevate your career by delivering precise inventory reconciliations across departments, ensuring financial accuracy and audit readiness. Utilize advanced data platforms to enhance operational efficien...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Aerospace & Defense

$150K - $180K *

Lead groundbreaking research in AI safety and evaluation, bridging academic rigor with real-world challenges. Drive innovative methodologies and collaborate with top-tier institutions to enhance respo...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Enterprise Technology

$110K - $130K *

Champion operational excellence at a high-volume distribution center, leading multi-shift teams in fulfillment, inventory management, and automation initiatives while driving continuous improvement an...

1 week ago

  •   8 - 10 years exp.  •   Real Estate & Construction

$83K - $222K *

Drive innovation by delivering high-quality web applications and interactive dashboards. Collaborate with cross-functional teams to integrate AI capabilities and build resilient APIs in a fast-paced...

RemoteRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$65K - $98K *

Lead and develop high-performing teams while ensuring operational excellence and compliance. Drive productivity and quality standards, fostering a culture of integrity and belonging to achieve busines...

1 week ago

  •   Less than 5 years exp.  •   Retail & Consumer Goods

Frequently Asked Questions (FAQ)

  • What types of $100,000+ jobs can I find in Mississippi?question toggle

    Listings may include senior roles in healthcare, technology, manufacturing, finance, energy, engineering, and management. Opportunities change over time, so check current listings for available positions.

  • Which Mississippi cities have high-paying job opportunities?question toggle

    Professional opportunities may be listed in Jackson, Gulfport, Biloxi, Hattiesburg, Southaven, and other parts of the state, depending on employer hiring needs.

  • Are remote jobs available to Mississippi residents?question toggle

    Some employers offer remote or hybrid positions that may be open to Mississippi-based candidates. Review each listing to confirm location and work arrangement requirements.

  • How can I qualify for a $100,000+ job in Mississippi?question toggle

    Requirements vary by role. Employers commonly seek relevant experience, specialized skills, and a record of strong results; senior positions may also require leadership experience or advanced credentials.