Explore $100K+ Jobs in Mississippi

Discover professional opportunities in Mississippi with salaries of $100,000 or more. Ladders features vetted roles for experienced candidates seeking senior-level careers across the Magnolia State, from Jackson and the Gulf Coast to regional business hubs.

Mississippi Careers Across Industries

High-paying opportunities may be available in healthcare, technology, manufacturing, finance, energy, engineering, and executive leadership. Job availability and requirements vary by employer, location, and experience level, so review each listing for details.

Find Opportunities by Location

Search roles in Jackson, Gulfport, Biloxi, Hattiesburg, Southaven, and other Mississippi communities. You can also consider remote and hybrid positions with employers hiring professionals based in the state.

How to Search Mississippi Jobs on Ladders

Explore current listings, compare responsibilities and compensation details, and focus your search on roles that match your skills and career goals. Tailor your résumé to highlight measurable results, leadership experience, and relevant expertise when applying.

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1,000+

Jobs in Mississippi

Average Salary in USD

Average Salary: $110,967

Sort By: Relevance

$100K - $120K *

Elevate project success by developing precise cost estimates for complex construction initiatives. Collaborate with teams to analyze costs, prepare reports, and guide projects from concept to delivery...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Real Estate & Construction

$84K - $129K *

Empower your career by joining a dynamic team in structural engineering, tackling innovative projects in nuclear facilities. Collaborate, guide, and utilize advanced tools to design and analyze struct...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Technical Services

$175K - $320K *

Champion mission-critical project delivery by leading multidisciplinary teams, ensuring safety, quality, and efficiency. Drive financial performance and client satisfaction through strategic planning...

United StatesRemote

1 week ago

  •   11 - 15 years exp.  •   Real Estate & Construction

$200K - $300K *

Lead the charge in managing large-scale mission-critical projects, ensuring strategic execution, financial performance, and team development. Drive client satisfaction and operational excellence in fa...

United StatesRemote

1 week ago

  •   11 - 15 years exp.  •   Real Estate & Construction

$83K - $99K *

Oversee daily operations of the Juvenile Detention Department, ensuring safety, staff management, and compliance with regulations while coordinating with various agencies to enhance service delivery a...

1 week ago

  •   Less than 5 years exp.  •   Education, Government & Non-Profit

$193K - $308K *

Join a team that's redefining statistical leadership in clinical research. Drive innovative study designs, enhance drug development effectiveness, and influence critical decisions through data-driven...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$71K - $125K *

Unlock potential by designing and delivering engaging training programs for data center professionals. Collaborate with experts to enhance learning experiences and ensure operational excellence in a d...

1 week ago

  •   Less than 5 years exp.  •   Retail & Consumer Goods

$150K - $230K *

Drive impactful oncology solutions by building relationships with key stakeholders, promoting innovative products, and exceeding performance goals in a dynamic biopharma environment. Collaborate effec...

United StatesRemote

1 week ago

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

$150K - $230K *

Unlock potential by driving oncology product success through strategic relationships and innovative solutions. Lead market engagement, exceed performance goals, and ensure patient access while embodyi...

United StatesRemote

1 week ago

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

$150K - $230K *

Engage with key stakeholders to promote oncology products, build relationships, and drive brand value. Utilize market insights to develop effective strategies, ensuring patient access and compliance w...

United StatesRemote

1 week ago

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

$150K - $230K *

Elevate oncology product promotion by building strong relationships with key stakeholders. Drive performance goals through effective marketing strategies and innovative solutions, ensuring timely acce...

United StatesRemote

1 week ago

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

$150K - $230K *

Champion the promotion of oncology products, building strong relationships with key stakeholders. Drive performance goals, manage territory effectively, and ensure patient access to treatments while e...

United StatesRemote

1 week ago

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

$150K - $230K *

Drive the promotion of oncology products by building relationships with key stakeholders, exceeding performance goals, and ensuring patient access to therapies while managing territory resources effec...

United StatesRemote

1 week ago

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

$150K - $230K *

Unlock potential by driving oncology product success through strategic relationships and innovative solutions. Lead efforts to enhance patient access and exceed performance goals while navigating a co...

United StatesRemote

1 week ago

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

$150K - $230K *

Accelerate progress at Revolution Medicines by driving oncology product sales, building strong relationships with healthcare professionals, and ensuring patient access to innovative therapies in a dyn...

United StatesRemote

1 week ago

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

$80K - $95K *

Transform automation systems by leading controls hardware projects, from design to implementation. Drive innovation in electrical design, mentor engineers, and ensure high-quality project delivery whi...

RemoteRemote

Reposted 1 week ago

  •   Less than 5 years exp.  •   Manufacturing & Automotive

$110K - $172K *

Optimize your career by managing the full contract lifecycle, ensuring compliance, and driving profitable execution of agreements. Collaborate with cross-functional teams to enhance customer relations...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$135K - $160K *

Join a team that's shaping the future of Oracle Cloud solutions. As a Delivery Architect, you'll lead complex projects, guide clients through implementations, and drive innovative strategies to optimi...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Enterprise Technology

$130K - $150K *

Champion clinical project success by leading operations, training teams, and ensuring compliance. Drive strategic planning and risk management while overseeing site performance and fostering collabora...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$160K - $180K *

Champion growth and satisfaction by managing key Ecosystem client relationships. Drive sales of innovative data solutions in Life Sciences, leveraging deep industry knowledge to meet client needs and...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Healthcare

$90K - $150K *

Transform global support operations by architecting an AI-driven knowledge strategy. Lead initiatives to enhance internal and external knowledge management, driving efficiency and customer satisfactio...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Business Services

$110K - $130K *

Join a team that's shaping federal policy and advocacy. As a Government Affairs Manager, you'll engage with Congress and the Executive Branch, driving strategic initiatives across key domestic issues...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$145K - $170K *

Champion the optimization and maintenance of existing systems, collaborating with engineers to enhance SLI/SLO operations and disaster recovery planning. Gain broad exposure in a small team, shaping p...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Retail & Consumer Goods

$80K - $95K *

Innovate clinical system implementations by ensuring seamless integration of technologies and workflows. Collaborate with clinical and technical teams to enhance patient care and operational efficienc...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$135K - $160K *

Lead the charge in developing a cutting-edge AI product, managing a high-performing team of engineers while ensuring quality, reliability, and speed in delivery. Collaborate closely with Product and D...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Enterprise Technology

Frequently Asked Questions (FAQ)

  • What types of $100,000+ jobs can I find in Mississippi?question toggle

    Listings may include senior roles in healthcare, technology, manufacturing, finance, energy, engineering, and management. Opportunities change over time, so check current listings for available positions.

  • Which Mississippi cities have high-paying job opportunities?question toggle

    Professional opportunities may be listed in Jackson, Gulfport, Biloxi, Hattiesburg, Southaven, and other parts of the state, depending on employer hiring needs.

  • Are remote jobs available to Mississippi residents?question toggle

    Some employers offer remote or hybrid positions that may be open to Mississippi-based candidates. Review each listing to confirm location and work arrangement requirements.

  • How can I qualify for a $100,000+ job in Mississippi?question toggle

    Requirements vary by role. Employers commonly seek relevant experience, specialized skills, and a record of strong results; senior positions may also require leadership experience or advanced credentials.