Explore $100K+ Jobs in Mississippi

Discover professional opportunities in Mississippi with salaries of $100,000 or more. Ladders features vetted roles for experienced candidates seeking senior-level careers across the Magnolia State, from Jackson and the Gulf Coast to regional business hubs.

Mississippi Careers Across Industries

High-paying opportunities may be available in healthcare, technology, manufacturing, finance, energy, engineering, and executive leadership. Job availability and requirements vary by employer, location, and experience level, so review each listing for details.

Find Opportunities by Location

Search roles in Jackson, Gulfport, Biloxi, Hattiesburg, Southaven, and other Mississippi communities. You can also consider remote and hybrid positions with employers hiring professionals based in the state.

How to Search Mississippi Jobs on Ladders

Explore current listings, compare responsibilities and compensation details, and focus your search on roles that match your skills and career goals. Tailor your résumé to highlight measurable results, leadership experience, and relevant expertise when applying.

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1,000+

Jobs in Mississippi

Average Salary in USD

Average Salary: $110,967

Sort By: Relevance

$65K - $108K *

Lead the charge in ensuring coding accuracy and compliance by reviewing medical records and documentation. Utilize ICD-10 and CPT systems to uphold quality standards while responding to coder inquirie...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Business Services

$120K - $145K *

Accelerate progress at a dynamic marketplace by owning the Driver App, enhancing user experience, and driving engagement. Collaborate cross-functionally to optimize workflows and improve marketplace h...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Real Estate & Construction

$110K - $130K *

Drive the design and enhancement of corporate security infrastructure, improving automation and maintaining strong security posture in a cloud environment. Collaborate with teams to implement controls...

United StatesRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Enterprise Technology

$100K - $150K *

Drive strategic sales initiatives and expand business within light industrial, hospitality, and retail sectors. Manage full sales process from prospecting to closing while collaborating across teams t...

United StatesRemote

Reposted 1 week ago

  •   Less than 5 years exp.  •   Staffing

$165K - $185K *

Lead the charge in transforming organizations through AI adoption. Collaborate with cross-functional teams to design and implement innovative solutions that enhance productivity and drive measurable o...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Information Technology

$145K - $160K *

Drive the future of Workforce AI by leading business development initiatives, engaging with executives, and translating complex technology into impactful solutions that enhance enterprise productivity...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Information Technology

$155K - $160K *

Drive the data and AI strategy by collaborating with clients, shaping predictive roadmaps, and translating complex problems into actionable product development, enhancing customer-facing analytics and...

United StatesRemote

Reposted 1 week ago

  •   Less than 5 years exp.  •   Consumer Technology

$210K - $250K *

Grow your career by providing comprehensive diagnostic radiology services, including consultations and interpretations for a diverse patient population. Collaborate remotely to ensure timely and accur...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Education, Government & Non-Profit

$180K - $205K *

Champion client success by managing strategic accounts, driving growth, and enhancing relationships with health plans. Collaborate cross-functionally to deliver tailored solutions and ensure seamless...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Information Technology

$80K - $120K *

Grow your career with a dynamic team focused on client retention and revenue growth. Drive go-to-market strategies for new products while nurturing key relationships and championing client needs in a...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Food & Beverages

$130K - $176K *

Inspire operational excellence as a strategic leader overseeing 8-10 pharmacies. Drive compliance, enhance patient care, and develop talent while ensuring consistent performance across multiple locati...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Retail & Consumer Goods

$145K - $185K *

Lead enterprise-level architectural initiatives to enhance endpoint technologies, guiding modernization efforts and integrating emerging solutions across multiple divisions while ensuring security and...

United StatesRemote

1 week ago

  •   11 - 15 years exp.  •   Information Technology

$150K - $180K *

Champion a transformative product vision, leading cross-functional teams to drive strategic outcomes in a dynamic digital health environment. Shape the future of patient care and client experience whi...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Healthcare

$80K - $95K *

Shape the future of content marketing by owning strategy and execution across channels. Collaborate with teams to create impactful, high-quality content that resonates with audiences and drives engage...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Enterprise Technology

$136K - $155K *

Champion integrated B2B marketing strategies by leading client relationships, driving account growth, and connecting marketing performance to business outcomes. Collaborate with cross-functional teams...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Business Services

$180K - $220K *

Lead the integration of complex defense solutions by translating tactical requirements into innovative products. Collaborate with cross-functional teams to optimize performance and drive market adopti...

RemoteRemote

1 week ago

  •   5 - 7 years exp.  •   Telecommunications & Hardware

$180K - $220K *

Innovate your career by joining a dynamic team focused on translating complex defense requirements into actionable software features, driving product adoption and revenue growth in the Spectrum Domina...

RemoteRemote

1 week ago

  •   5 - 7 years exp.  •   Telecommunications & Hardware

$100K - $115K *

Join a team that's dedicated to enhancing customer success through expert management of software solutions, ensuring exceptional service delivery and operational excellence in public safety environmen...

RemoteRemote

1 week ago

  •   Less than 5 years exp.  •   Telecommunications & Hardware

$83K - $105K *

Join a dynamic team to lead product quality initiatives, ensuring excellence from supplier to customer. Drive continuous improvement and defect prevention while fostering a culture of quality and acco...

1 week ago

  •   Less than 5 years exp.  •   Energy & Utilities

$120K - $180K *

Drive the growth of our partner channel by leading recruitment and strategy for ISVs, VARs, and ISOs in the payments landscape. Collaborate across teams to enhance partner relationships and expand rev...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Finance & Insurance

$150K - $165K *

Transform your career by leading technical direction and architecture for complex systems. Collaborate across teams to drive innovation, establish standards, and mentor engineers while ensuring alignm...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Finance & Insurance

$95K - $106K *

Optimize legal operations by providing expert advice on contracts, collaborating with teams, and ensuring compliance. Leverage your transactional law experience to streamline processes and support the...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Media

$105K - $136K *

Shape the future of animal welfare by leading innovative research projects focused on companion animal behavior and welfare. Collaborate across teams to translate findings into impactful applications...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Hospitality & Recreation

$150K - $180K *

Join a team that's shaping the future of platform engineering, driving innovation across cloud, DevOps, and site reliability. This role empowers you to build core services, enhance architecture, and m...

RemoteRemote

Reposted 1 week ago

  •   11 - 15 years exp.  •   Manufacturing & Automotive

$145K - $157K *

Transform space operations by leveraging Kubernetes to deliver resilient solutions. Collaborate within an Agile framework to enhance software deployment, ensuring optimal performance and security for...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Technical Services

Frequently Asked Questions (FAQ)

  • What types of $100,000+ jobs can I find in Mississippi?question toggle

    Listings may include senior roles in healthcare, technology, manufacturing, finance, energy, engineering, and management. Opportunities change over time, so check current listings for available positions.

  • Which Mississippi cities have high-paying job opportunities?question toggle

    Professional opportunities may be listed in Jackson, Gulfport, Biloxi, Hattiesburg, Southaven, and other parts of the state, depending on employer hiring needs.

  • Are remote jobs available to Mississippi residents?question toggle

    Some employers offer remote or hybrid positions that may be open to Mississippi-based candidates. Review each listing to confirm location and work arrangement requirements.

  • How can I qualify for a $100,000+ job in Mississippi?question toggle

    Requirements vary by role. Employers commonly seek relevant experience, specialized skills, and a record of strong results; senior positions may also require leadership experience or advanced credentials.