Explore $100K+ Jobs in Mississippi

Discover professional opportunities in Mississippi with salaries of $100,000 or more. Ladders features vetted roles for experienced candidates seeking senior-level careers across the Magnolia State, from Jackson and the Gulf Coast to regional business hubs.

Mississippi Careers Across Industries

High-paying opportunities may be available in healthcare, technology, manufacturing, finance, energy, engineering, and executive leadership. Job availability and requirements vary by employer, location, and experience level, so review each listing for details.

Find Opportunities by Location

Search roles in Jackson, Gulfport, Biloxi, Hattiesburg, Southaven, and other Mississippi communities. You can also consider remote and hybrid positions with employers hiring professionals based in the state.

How to Search Mississippi Jobs on Ladders

Explore current listings, compare responsibilities and compensation details, and focus your search on roles that match your skills and career goals. Tailor your résumé to highlight measurable results, leadership experience, and relevant expertise when applying.

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1,000+

Jobs in Mississippi

Average Salary in USD

Average Salary: $110,967

Sort By: Relevance

$90K - $110K *

Unlock potential by enhancing revenue operations through data-driven workflows, improving systems, and automating processes. Collaborate with cross-functional teams to ensure efficiency and scalabilit...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Information Technology

$120K - $130K *

Manage construction projects for new builds and remodels, overseeing vendors and maintaining quality standards while ensuring timely delivery and adherence to budgets. Foster collaboration with stakeh...

United StatesRemote

Reposted 1 week ago

  •   8 - 10 years exp.  •   Retail & Consumer Goods

$120K - $135K *

Transform compliance oversight in the DME order-to-payment lifecycle. Lead audits, analyze data, and coordinate payer audits while developing practical controls and reporting to enhance revenue integr...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Healthcare

$120K - $150K *

Transform communities by leading roadway design projects, ensuring timely execution and budget management while collaborating with clients and teams to deliver impactful transportation solutions...

1 week ago

  •   5 - 7 years exp.  •   Finance & Insurance

$125K - $150K *

Drive impactful engineering solutions by leading a multidisciplinary team in delivering innovative projects across water and transportation sectors, ensuring quality and efficiency within budget and t...

1 week ago

  •   5 - 7 years exp.  •   Finance & Insurance

$165K - $190K *

Lead the charge in shaping financial strategy and operations, overseeing accounting, financial planning, and analysis. Drive integration across revenue models while managing a skilled finance team to...

United StatesRemote

1 week ago

  •   11 - 15 years exp.  •   Enterprise Technology

$86K - $144K *

Unlock potential by leading the design and development of scalable generative AI services, ensuring architectural integrity and mentoring teams. Collaborate with cross-functional stakeholders to drive...

United StatesRemote

Reposted 1 week ago

  •   Less than 5 years exp.  •   Retail & Consumer Goods

$80K - $107K *

Join us to develop and manage educational resources that enhance Commercial readiness across clinical data solutions. Collaborate with cross-functional teams to translate complex information into acti...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Healthcare

$100K - $120K *

Elevate customer relationships by managing and growing strategic national accounts. Focus on retention, upselling, and cross-selling within the Collision and Mechanical sectors while leveraging SaaS s...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Consumer Technology

$143K - $183K *

Shape the future of security testing by identifying vulnerabilities in AI-driven systems. Collaborate with engineers to enhance security protocols and tools, ensuring robust protection for innovative...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Finance & Insurance

$125K - $150K *

Join a team that's dedicated to providing exceptional post-sales technical support for federal clients. You'll troubleshoot complex systems, collaborate with engineering teams, and ensure seamless ope...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Information Technology

$274K - $371K *

Develop and lead early phase clinical strategies for oncology candidates, ensuring design and execution of clinical trials. Collaborate with internal teams and external experts to drive innovative dru...

United StatesRemote

Reposted 1 week ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$70K - $142K *

Join a team that's dedicated to driving successful product launches and maximizing adoption. This role coordinates cross-functional efforts, ensuring effective communication and readiness across depar...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Consumer Technology

$175K - $200K *

Optimize our data infrastructure platform by enhancing automation, observability, and stability. Drive architectural changes to support long-term service requirements while ensuring high throughput an...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Enterprise Technology

$80K - $90K *

Champion the analysis and resolution of complex liability claims, ensuring timely adjudication and client satisfaction. Collaborate with a dedicated team while leveraging industry expertise across mul...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Finance & Insurance

$132K - $178K *

Lead a dynamic team to optimize quality oversight through data-driven insights, ensuring compliance and continuous improvement in R&D processes. Drive governance and operational excellence in quality...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$199K - $334K *

Champion the architecture and engineering of agent memory systems, leading the development of context-driven AI agents. Drive innovation and technical direction while collaborating across teams to enh...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Real Estate & Construction

$110K - $130K *

Transform your career by driving market development in quantum technology. Engage with strategic accounts and forge strong relationships while identifying new business opportunities and expanding exis...

United StatesRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Consumer Technology

$138K - $150K *

Elevate your career by managing corporate portfolio growth through strategic projects and business development in a dynamic environment. Collaborate with leadership and cross-functional teams to drive...

1 week ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$138K - $150K *

Analyze and manage corporate portfolio growth through strategic projects and business development. Collaborate with cross-functional teams to drive M&A initiatives and evaluate market opportunities, e...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$190K - $225K *

Unlock potential by driving welding sales growth through hands-on expertise and strategic partnerships. Collaborate with regional teams to enhance customer experiences and lead the market in robotic w...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$87K - $120K *

Champion business process excellence by bridging stakeholders and IT teams, driving Salesforce solutions, and optimizing workflows to enhance operational efficiency and user experience across the orga...

RemoteRemote

1 week ago

  •   5 - 7 years exp.  •   Consumer Technology

$160K - $190K *

Elevate your career by leading global commercial planning and forecasting efforts. Drive strategic decision-making, optimize supply allocation, and enhance business development through robust analytic...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$93K - $124K *

Lead the charge in enhancing asset reliability and minimizing downtime through innovative engineering solutions. Collaborate across all organizational levels to drive sustainable improvements in manuf...

1 week ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$93K - $124K *

Transform reliability engineering by eliminating downtime and enhancing asset life. Collaborate across all organizational levels to drive sustainable improvements in manufacturing systems, ensuring op...

1 week ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

Frequently Asked Questions (FAQ)

  • What types of $100,000+ jobs can I find in Mississippi?question toggle

    Listings may include senior roles in healthcare, technology, manufacturing, finance, energy, engineering, and management. Opportunities change over time, so check current listings for available positions.

  • Which Mississippi cities have high-paying job opportunities?question toggle

    Professional opportunities may be listed in Jackson, Gulfport, Biloxi, Hattiesburg, Southaven, and other parts of the state, depending on employer hiring needs.

  • Are remote jobs available to Mississippi residents?question toggle

    Some employers offer remote or hybrid positions that may be open to Mississippi-based candidates. Review each listing to confirm location and work arrangement requirements.

  • How can I qualify for a $100,000+ job in Mississippi?question toggle

    Requirements vary by role. Employers commonly seek relevant experience, specialized skills, and a record of strong results; senior positions may also require leadership experience or advanced credentials.