Explore $100K+ Jobs in Mississippi

Discover professional opportunities in Mississippi with salaries of $100,000 or more. Ladders features vetted roles for experienced candidates seeking senior-level careers across the Magnolia State, from Jackson and the Gulf Coast to regional business hubs.

Mississippi Careers Across Industries

High-paying opportunities may be available in healthcare, technology, manufacturing, finance, energy, engineering, and executive leadership. Job availability and requirements vary by employer, location, and experience level, so review each listing for details.

Find Opportunities by Location

Search roles in Jackson, Gulfport, Biloxi, Hattiesburg, Southaven, and other Mississippi communities. You can also consider remote and hybrid positions with employers hiring professionals based in the state.

How to Search Mississippi Jobs on Ladders

Explore current listings, compare responsibilities and compensation details, and focus your search on roles that match your skills and career goals. Tailor your résumé to highlight measurable results, leadership experience, and relevant expertise when applying.

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1,000+

Jobs in Mississippi

Average Salary in USD

Average Salary: $110,967

Sort By: Relevance

$62K - $97K *

Join a dynamic team as you manage cloud-based marketing tools, ensuring optimal performance and user adoption. Collaborate across departments to implement solutions that drive business success and enh...

RemoteRemote

1 week ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$150K - $197K *

Lead strategic initiatives as a trusted advisor to the CEO, enhancing organizational effectiveness through cross-functional collaboration, executive representation, and performance monitoring to achie...

RemoteRemote

1 week ago

  •   11 - 15 years exp.  •   Education, Government & Non-Profit

$90K - $153K *

Lead the enhancement and administration of enterprise endpoint security technologies, collaborating with cross-functional teams to optimize security processes and improve detection capabilities in a g...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Finance & Insurance

$114K - $172K *

Drive strategic growth by leading enterprise accounts in Chicago, guiding influential organizations through complex digital transformations with GitLab's AI-powered DevSecOps platform, and building lo...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Information Technology

$280K *

Lead the charge in driving enterprise sales across the TOLA region, building strong relationships and collaborating with cross-functional teams to deliver exceptional customer experiences and achieve...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Information Technology

$95K - $120K *

Join a team that's dedicated to advancing reproductive medicine by driving sales and building relationships with healthcare professionals. Leverage your expertise to promote innovative products and ac...

1 week ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$110K - $145K *

Strategize initiatives to enhance workforce alignment and Agile practices, driving high performance in IT services for federal clients while fostering a collaborative culture and supporting strategic...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Information Technology

$61K - $98K *

Transform the landscape of risk management by overseeing collections and funding returns, analyzing transaction patterns, and collaborating with teams to resolve complex cases while driving process im...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Enterprise Technology

$100K - $120K *

Transform customer success by driving adoption and value realization for advisory teams. Collaborate cross-functionally to enhance workflows and deliver measurable outcomes, ensuring clients achieve e...

RemoteRemote

1 week ago

  •   Less than 5 years exp.  •   Enterprise Technology

$126K - $189K *

Transform customer engagements by leveraging your financial management expertise to deliver compelling demonstrations and articulate the value of advanced cloud-based solutions to prospective clients...

RemoteRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Consumer Technology

$79K - $127K *

Optimize member health outcomes by managing complex care plans, coordinating services, and advocating for quality, cost-effective healthcare. Collaborate with healthcare teams to assess needs and moni...

RemoteRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Healthcare

$105K - $115K *

Join a team that's focused on diversifying paid media channels and optimizing conversion strategies. You'll lead initiatives across affiliate, programmatic, and social platforms to enhance member acqu...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Healthcare

$172K - $188K *

Lead the charge in clinical data programming by designing, building, and maintaining data collection systems. Collaborate with teams to ensure data integrity and support clinical development through a...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$156K - $195K *

Champion the global eDiscovery Technology practice, leading a diverse team to innovate AI-assisted workflows, ensuring defensibility and quality across jurisdictions while driving growth and operation...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Legal & Accounting

$80K - $95K *

Accelerate your career by driving revenue growth and managing key accounts in the Western U.S. and Canada. Focus on expanding customer relationships and delivering value through consultative selling w...

RemoteRemote

1 week ago

  •   5 - 7 years exp.  •   Consumer Technology

$135K - $146K *

Innovate strategic partnerships and drive revenue growth in NTN and IoT sectors. Cultivate relationships with global carriers, negotiate agreements, and identify new business opportunities to establis...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Telecommunications & Hardware

$90K - $190K *

Innovate and optimize paid search strategies to enhance student enrollment and product adoption. Lead campaign execution, manage agency partnerships, and drive performance improvements through data an...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Education, Government & Non-Profit

$80K - $95K *

Drive impactful oceanographic and acoustic studies to enhance METOC forecasting for naval operations. Collaborate with experts to develop training and instructional materials, ensuring operational rea...

1 week ago

  •   Less than 5 years exp.  •   Transportation

$152K - $190K *

Unlock growth by driving IoT solutions for mid-sized customers, managing complex sales cycles, and engaging with executives to deliver impactful sensor data solutions. Your efforts will enhance operat...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Enterprise Technology

$152K - $190K *

Lead the charge in bringing IoT solutions to mid-sized customers, managing complex sales cycles and building lasting relationships. Drive impactful change across industries while navigating multi-stak...

RemoteRemote

1 week ago

  •   Less than 5 years exp.  •   Enterprise Technology

$120K - $145K *

Lead the design and implementation of Moveworks AI solutions, integrating with ServiceNow to enhance enterprise workflows. Collaborate with teams to deliver innovative, scalable solutions that transfo...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Enterprise Technology

$110K - $130K *

Transform the future of product management by leading AI-driven initiatives, collaborating across teams, and shaping strategies that enhance customer experiences and drive business growth in a dynamic...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Enterprise Technology

$240K - $269K *

Advance your career by leading national account strategies in oncology, fostering relationships with health plans and PBMs. Drive coverage, reimbursement, and adoption initiatives while collaborating...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$80K - $110K *

Drive client growth by enhancing software adoption and satisfaction. Collaborate with sales and success teams to implement strategies, facilitate demos, and manage client relationships, ensuring long...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Information Technology

$228K - $285K *

Shape the future of market access by leading strategic account initiatives, fostering key relationships, and driving collaboration across teams to enhance product access and reimbursement in the oncol...

United StatesRemote

1 week ago

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

Frequently Asked Questions (FAQ)

  • What types of $100,000+ jobs can I find in Mississippi?question toggle

    Listings may include senior roles in healthcare, technology, manufacturing, finance, energy, engineering, and management. Opportunities change over time, so check current listings for available positions.

  • Which Mississippi cities have high-paying job opportunities?question toggle

    Professional opportunities may be listed in Jackson, Gulfport, Biloxi, Hattiesburg, Southaven, and other parts of the state, depending on employer hiring needs.

  • Are remote jobs available to Mississippi residents?question toggle

    Some employers offer remote or hybrid positions that may be open to Mississippi-based candidates. Review each listing to confirm location and work arrangement requirements.

  • How can I qualify for a $100,000+ job in Mississippi?question toggle

    Requirements vary by role. Employers commonly seek relevant experience, specialized skills, and a record of strong results; senior positions may also require leadership experience or advanced credentials.