Explore $100K+ Jobs in Mississippi

Discover professional opportunities in Mississippi with salaries of $100,000 or more. Ladders features vetted roles for experienced candidates seeking senior-level careers across the Magnolia State, from Jackson and the Gulf Coast to regional business hubs.

Mississippi Careers Across Industries

High-paying opportunities may be available in healthcare, technology, manufacturing, finance, energy, engineering, and executive leadership. Job availability and requirements vary by employer, location, and experience level, so review each listing for details.

Find Opportunities by Location

Search roles in Jackson, Gulfport, Biloxi, Hattiesburg, Southaven, and other Mississippi communities. You can also consider remote and hybrid positions with employers hiring professionals based in the state.

How to Search Mississippi Jobs on Ladders

Explore current listings, compare responsibilities and compensation details, and focus your search on roles that match your skills and career goals. Tailor your résumé to highlight measurable results, leadership experience, and relevant expertise when applying.

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1,000+

Jobs in Mississippi

Average Salary in USD

Average Salary: $110,974

Sort By: Relevance

$175K - $190K *

Innovate with us as a strategic consultant, guiding ERP and Payroll transformations. Leverage your Workday expertise to shape client strategies, enhance operational readiness, and drive impactful chan...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Enterprise Technology

$80K - $95K *

Join a dynamic team as you lead digital marketing initiatives, focusing on webinars and paid advertising to drive engagement and generate leads. Collaborate with stakeholders to optimize strategies an...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Information Technology

$110K - $130K *

Empower channel growth by managing key partnerships, driving sales acceleration, and collaborating with cross-functional teams to exceed performance goals in the Ohio Valley Region...

RemoteRemote

1 week ago

  •   Less than 5 years exp.  •   Information Technology

$135K - $160K *

Transform the Teleport Core Product by tackling performance, scalability, and security challenges. Lead a distributed team to design, develop, and implement high-quality solutions while enhancing obse...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Information Technology

$208K - $220K *

Drive enterprise leadership in clinical quality and regulatory readiness, ensuring consistent standards and governance across regions. Collaborate with stakeholders to translate quality insights into...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Healthcare

$120K - $145K *

Drive the design and optimization of Oracle CX data architecture, ensuring effective data conversion and integration. Collaborate with cross-functional teams to enhance customer experience through inn...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Staffing

$120K - $145K *

Champion innovative Oracle Cloud ERP solutions by leading design and implementation of Procure-to-Pay processes. Collaborate with stakeholders to translate business needs into effective, scalable arch...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Staffing

$180K - $215K *

Elevate regional sales performance by leading a high-performing team, executing launch strategies, and fostering customer relationships in a dynamic environment. Drive accountability and collaboration...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$138K - $172K *

Empower revenue teams as a Senior Business Systems Analyst, driving efficiency through Salesforce architecture, process design, and actionable data across GTM, Marketing, Sales, and Customer Success o...

United StatesRemote

Reposted 1 week ago

  •   Less than 5 years exp.  •   Enterprise Technology

$76K - $148K *

Play a key role in managing clinical trials, ensuring compliance and quality oversight of project deliverables while collaborating with cross-functional teams to meet timelines and budget goals...

RemoteRemote

Reposted 1 week ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$80K - $110K *

Lead the charge in transforming K-12 financial solutions by engaging C-level officials. Drive sales cycles, build relationships, and leverage insights to exceed quotas while collaborating with interna...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Education, Government & Non-Profit

$80K - $115K *

Shape the future of client onboarding by leading implementation processes, ensuring satisfaction, and driving best practices in a dynamic environment. Collaborate with teams to enhance client experien...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Enterprise Technology

$110K - $130K *

Transform your career by leading brand identity and design initiatives, driving AI integration in creative processes, and collaborating across teams to elevate visual storytelling and brand consistenc...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Information Technology

$110K - $130K *

Lead the charge in transforming complex genomic data into compelling narratives that resonate with audiences, driving engagement across diverse channels while collaborating with cross-functional teams...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Healthcare

$120K - $150K *

Empower a cross-functional team by owning the end-to-end design experience for a key product area, enhancing communication for families and educators while mentoring fellow designers and leveraging AI...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Education, Government & Non-Profit

$112K - $140K *

Join a team that's shaping the voice of a vibrant music community. Drive organic social strategy, engage creators, and manage community programming while leveraging data to enhance our impact and grow...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Consumer Technology

$120K - $150K *

Elevate your career by leading clinical trial management teams, ensuring quality and compliance in monitoring strategies. Collaborate with cross-functional teams to optimize clinical operations and dr...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$110K - $130K *

Drive procurement excellence by managing vendor networks and asset supply chains for remote work solutions. Collaborate across teams to ensure scalable, compliant, and efficient deployment strategies...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Real Estate & Construction

$128K - $148K *

Join a dynamic team as you drive utility-scale clean energy projects, managing their lifecycle from strategy to execution. Collaborate with experts to deliver innovative power solutions across key U.S...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Energy & Utilities

$217K - $237K *

Lead the development of innovative utility-scale clean energy projects, driving strategy and execution across diverse markets. Collaborate with experts to tackle complex challenges and deliver high-im...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Energy & Utilities

$80K - $95K *

Discover a dynamic role focused on building relationships with credit unions to drive referrals and revenue. Collaborate with stakeholders, manage partnerships, and execute strategies that enhance AFA...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Finance & Insurance

$80K - $95K *

Transform healthcare auditing by conducting thorough medical claims reviews. Collaborate with a dynamic team to ensure compliance and improve processes while working remotely in a fast-paced environme...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Information Technology

$122K - $176K *

Join a team that's redefining cybersecurity marketing. Leverage your expertise to craft compelling narratives, drive product launches, and influence stakeholders, all while contributing to a rapidly g...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Information Technology

$157K - $185K *

Innovate the future of AI Security sales by owning the full sales cycle, targeting enterprise accounts, and collaborating with cross-functional teams to drive growth and shape product offerings in a r...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Information Technology

$177K - $364K *

Empower a team of engineers to enhance Kubernetes platform infrastructure, driving reliability, security, and efficiency while collaborating across departments to achieve strategic goals and operation...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Consumer Technology

Frequently Asked Questions (FAQ)

  • What types of $100,000+ jobs can I find in Mississippi?question toggle

    Listings may include senior roles in healthcare, technology, manufacturing, finance, energy, engineering, and management. Opportunities change over time, so check current listings for available positions.

  • Which Mississippi cities have high-paying job opportunities?question toggle

    Professional opportunities may be listed in Jackson, Gulfport, Biloxi, Hattiesburg, Southaven, and other parts of the state, depending on employer hiring needs.

  • Are remote jobs available to Mississippi residents?question toggle

    Some employers offer remote or hybrid positions that may be open to Mississippi-based candidates. Review each listing to confirm location and work arrangement requirements.

  • How can I qualify for a $100,000+ job in Mississippi?question toggle

    Requirements vary by role. Employers commonly seek relevant experience, specialized skills, and a record of strong results; senior positions may also require leadership experience or advanced credentials.