Discover professional opportunities in Mississippi with salaries of $100,000 or more. Ladders features vetted roles for experienced candidates seeking senior-level careers across the Magnolia State, from Jackson and the Gulf Coast to regional business hubs.
High-paying opportunities may be available in healthcare, technology, manufacturing, finance, energy, engineering, and executive leadership. Job availability and requirements vary by employer, location, and experience level, so review each listing for details.
Search roles in Jackson, Gulfport, Biloxi, Hattiesburg, Southaven, and other Mississippi communities. You can also consider remote and hybrid positions with employers hiring professionals based in the state.
Explore current listings, compare responsibilities and compensation details, and focus your search on roles that match your skills and career goals. Tailor your résumé to highlight measurable results, leadership experience, and relevant expertise when applying.
Average Salary: $110,974
Director, Brazoria County Opportunity Youth Reconnection Network
$80K - $95K *
Inspire community collaboration as a leader driving youth reconnection efforts. You'll unite diverse stakeholders to enhance education, training, and employment pathways for young people, ensuring las...
1 week ago
$160K - $200K *
Champion innovation as a Senior Software Engineer, driving full-stack solutions and leveraging AI tools to enhance IT lifecycle management. Collaborate with a dynamic team to deliver impactful softwar...
1 week ago
Territory Leader: St. Louis, Missouri
$80K - $95K *
Grow your career in pharmaceutical sales by building relationships in dermatology. This role involves extensive travel to engage with healthcare professionals, promote products, and achieve sales goal...
1 week ago
Software Engineer - Mercury Command
$122K - $176K *
Lead the charge in evolving a cutting-edge financial assistant, enhancing user experience through innovative features and AI integration while collaborating with cross-functional teams in a dynamic st...
1 week ago
Optometrist - Doctor of Optometry (Employee)
$200K *
Join a team that's dedicated to delivering exceptional eye care solutions while thriving in a dynamic, patient-centered environment. Utilize innovative technology to conduct comprehensive exams and cr...
1 week ago
$110K - $130K *
Lead the charge in executing digital product initiatives for veterinary health. Collaborate across teams to prioritize backlogs, write user stories, and enhance user experiences, ensuring alignment be...
1 week ago
Medical Affairs Technology and Digital Innovation Director
$190K - $238K *
Transform your career by leading the digital strategy for Medical Affairs. Drive innovation, optimize processes, and enhance scientific communications through emerging technologies while collaborating...
1 week ago
HPE SLED Channel Manager - West
$115K - $184K *
Advance HPE's growth in the West by driving strategic initiatives, fostering partner engagement, and enhancing market share within the public sector ecosystem. Collaborate with key stakeholders to cre...
1 week ago
$138K - $200K *
Transform partner success by leading a high-performing team of Channel Managers. Drive growth through innovative strategies, coaching, and collaboration across Microsoft’s ecosystem to achieve measura...
1 week ago
HPE SLED Channel Manager - East
$105K - $184K *
Champion growth in the public sector by driving strategic initiatives and partner engagement. Collaborate with key stakeholders to expand HPE's portfolio and influence revenue opportunities across the...
1 week ago
Specialty Representative/ Senior Specialty Representative – Bone Health - Jackson, MS (Overlay)
$89K - $155K *
Join a team that's dedicated to transforming patient care by leveraging your sales expertise to connect with medical professionals and drive product utilization in a dynamic healthcare environment...
1 week ago
Specialty Representative/ Senior Specialty Representative – Bone Health - Jackson, MS (Overlay)
$89K - $155K *
Empower healthcare professionals by delivering clinical insights and driving product utilization. As a key customer liaison, you'll implement marketing strategies and foster relationships to enhance p...
1 week ago
Bone Access & DMAB Patient Experience Lead, Marketing Senior Manager
$149K - $202K *
Make your mark at the forefront of patient access marketing, leading strategies and initiatives to enhance the Bone portfolio experience. Collaborate cross-functionally to optimize access solutions an...
1 week ago
Specialty/Senior Specialty Representative - Bone Health - Starksville/Hattiesburg, MS (Overlay)
$89K - $155K *
Join us to connect with medical professionals, delivering clinical insights and driving product utilization. As a key customer liaison, you'll implement marketing strategies and foster relationships t...
1 week ago
Medical Science Liaison - Obesity and Related Conditions - MS/AR
$156K - $212K *
Shape the future of obesity treatment by engaging with healthcare leaders, providing scientific insights, and driving patient outcomes through strategic collaboration and education in a dynamic field...
1 week ago
Senior Manager, Data Science & Advanced Analytics
$170K - $190K *
Transform data into actionable insights by leading a team of data scientists and analysts. Drive advanced analytics initiatives, foster collaboration with stakeholders, and ensure high-quality deliver...
1 week ago
Executive Director, Strategic Accounts
$246K - $332K *
Transform healthcare by leading national strategic account management efforts. Drive partnerships with key institutions, enhance patient care, and foster cross-functional collaboration to achieve comm...
1 week ago
Senior Director, Commercial Analytics & Decision Science
$219K - $285K *
Shape and lead a centralized commercial analytics function, transforming complex data into actionable insights. Drive performance measurement, growth identification, and strategic decision-making acro...
1 week ago
Distinguished Engineer, AI Security Systems (Remote)
$235K - $350K *
Transform the future of cyber defense by architecting cutting-edge AI systems that autonomously protect against real-world threats. Lead technical direction, mentor teams, and drive innovation from re...
1 week ago
Engineer II - Site Reliability, Kubernetes (Remote, EST)
$100K - $145K *
Elevate your career by managing Kubernetes clusters across diverse environments. Collaborate with senior engineers to automate processes, troubleshoot issues, and enhance platform performance while de...
1 week ago
Associate Counsel, Employment and Commercial
$110K - $130K *
Collaborate with HR and legal teams to provide comprehensive employment law support, drafting and negotiating contracts while ensuring compliance with regulations. Balance legal risks with business ob...
1 week ago
Senior Clinical Research Associate - Oncology
$105K - $140K *
Lead the charge in monitoring clinical study sites, ensuring data integrity and patient safety while collaborating with diverse teams to enhance study delivery and compliance with regulatory standards...
Reposted 1 week ago
$74K - $124K *
Elevate compensation strategies by transforming complex data into actionable insights. Collaborate with stakeholders to manage compensation programs, analyze trends, and recommend solutions that ensur...
1 week ago
Vice President, Franchise Sales Development - Extended Stay
$485K *
Transform franchise growth in the Extended Stay sector by leading strategic initiatives, managing a team of Regional Vice Presidents, and building key relationships to enhance development opportunitie...
1 week ago
$162K - $207K *
Lead the charge in implementing and optimizing SAP Vistex solutions, translating business strategies into technical architecture while managing cross-functional teams and project deliverables for enha...
1 week ago
What types of $100,000+ jobs can I find in Mississippi?
Listings may include senior roles in healthcare, technology, manufacturing, finance, energy, engineering, and management. Opportunities change over time, so check current listings for available positions.
Which Mississippi cities have high-paying job opportunities?
Professional opportunities may be listed in Jackson, Gulfport, Biloxi, Hattiesburg, Southaven, and other parts of the state, depending on employer hiring needs.
Are remote jobs available to Mississippi residents?
Some employers offer remote or hybrid positions that may be open to Mississippi-based candidates. Review each listing to confirm location and work arrangement requirements.
How can I qualify for a $100,000+ job in Mississippi?
Requirements vary by role. Employers commonly seek relevant experience, specialized skills, and a record of strong results; senior positions may also require leadership experience or advanced credentials.