Explore $100K+ Jobs in Mississippi

Discover professional opportunities in Mississippi with salaries of $100,000 or more. Ladders features vetted roles for experienced candidates seeking senior-level careers across the Magnolia State, from Jackson and the Gulf Coast to regional business hubs.

Mississippi Careers Across Industries

High-paying opportunities may be available in healthcare, technology, manufacturing, finance, energy, engineering, and executive leadership. Job availability and requirements vary by employer, location, and experience level, so review each listing for details.

Find Opportunities by Location

Search roles in Jackson, Gulfport, Biloxi, Hattiesburg, Southaven, and other Mississippi communities. You can also consider remote and hybrid positions with employers hiring professionals based in the state.

How to Search Mississippi Jobs on Ladders

Explore current listings, compare responsibilities and compensation details, and focus your search on roles that match your skills and career goals. Tailor your résumé to highlight measurable results, leadership experience, and relevant expertise when applying.

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1,000+

Jobs in Mississippi

Average Salary in USD

Average Salary: $110,974

Sort By: Relevance

$170K - $210K *

Engage as the senior creative leader, ensuring top-tier quality and performance across all creative outputs. Drive a culture of testing and learning while fostering strong client relationships and lea...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Media

$225K - $265K *

Accelerate progress at a mission-critical team, leading Data Streaming to enhance data ingestion pipelines. Build a skilled team, ensure pipeline reliability, and collaborate cross-functionally to sup...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Information Technology

$225K - $265K *

Lead and mentor a diverse team of backend engineers in EDR remediation, transforming insights into actionable product capabilities while managing scope and fostering collaboration across engineering t...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Information Technology

$95K - $115K *

Transform staff well-being by leading strategic initiatives that enhance resilience and psychosocial support across diverse, high-stress environments, ensuring alignment with organizational priorities...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Education, Government & Non-Profit

$80K - $100K *

Lead strategic sales initiatives to enhance Wireless, EMC, and Product Safety revenue. Cultivate new and existing customer relationships while driving technical discussions and solutions across divers...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Technical Services

$71K - $125K *

Lead the execution of CIAM strategy by optimizing authentication intelligence and fraud detection tools. Collaborate with cross-functional teams to enhance security, reduce friction, and drive data-in...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Finance & Insurance

$71K - $125K *

Transform complex loan servicing processes as a Senior Servicing Officer, managing a diverse portfolio in commercial real estate. Contribute to client partnerships and lead initiatives, while expandin...

RemoteRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Finance & Insurance

$80K - $150K *

Unlock secure customer experiences by designing and implementing identity solutions. Collaborate with cross-functional teams to enhance authentication processes, ensuring seamless onboarding and login...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Finance & Insurance

$150K - $245K *

Empower your career by leading regulatory advertising initiatives, ensuring compliance while collaborating with cross-functional teams to develop impactful product messaging for marketed and pipeline...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$128K - $210K *

Manage regulatory activities for advertising and promotion, ensuring compliance while collaborating with cross-functional teams to develop impactful product messaging and materials that align with com...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$150K - $190K *

Unlock potential by designing scalable data models and ensuring data quality. Collaborate with cross-functional teams to translate business needs into technical solutions, driving analytics excellence...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Finance & Insurance

$75K - $95K *

Shape the future of clinical research data integrity by leading a dedicated team. Drive operational excellence, ensure compliance, and foster cross-functional partnerships to enhance data quality and...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Healthcare

$136K - $200K *

Champion employee advocacy by leading initiatives that enhance workplace relationships, drive positive employee experiences, and ensure effective communication across teams, while leveraging data anal...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Retail & Consumer Goods

$90K - $120K *

Champion customer success by driving engagement and building lasting relationships with enterprise clients. Collaborate across teams to ensure exceptional user experiences and achieve measurable outco...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Information Technology

$95K - $115K *

Lead a dynamic content development team to create high-quality curriculum materials for K-8 science education. Oversee project management, ensure content consistency, and drive team performance to mee...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Food & Beverages

$178K - $366K *

Shape the future of privacy compliance by providing strategic counsel to cross-functional teams, ensuring products meet EU regulations while balancing business goals. Drive scalable processes and lead...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Consumer Technology

$110K - $130K *

Drive patient access to Provenge by removing reimbursement barriers and collaborating with healthcare stakeholders. Develop strategies to enhance business growth while navigating complex payer policie...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$160K - $200K *

Drive operational excellence by leading a global team to enhance post-sale services, optimize processes, and ensure customer satisfaction. Collaborate across departments to implement scalable solution...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Hospitality & Recreation

$81K - $90K *

Manage the leave of absence program, ensuring compliance and support for associates. Collaborate with stakeholders to enhance leave experiences and ADA accommodations while maintaining accurate record...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Healthcare

$150K - $180K *

Drive the planning and execution of complex therapeutic programs from discovery to clinic. Serve as a senior program management partner, ensuring successful execution and alignment across cross-functi...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$100K - $120K *

Shape the future of LPG tank sales by driving revenue growth and building lasting relationships across the Western US. Lead customer engagement, execute strategic initiatives, and ensure consistent pe...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Manufacturing & Automotive

$120K - $160K *

Transform data into actionable insights by owning the analytics pipeline from ingestion to visualization. Collaborate with cross-functional teams to create trusted models and metrics that empower deci...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Hospitality & Recreation

$120K - $135K *

Champion global retail operations by optimizing fulfillment processes, enhancing customer satisfaction, and managing relationships with 3PLs and retailers. Collaborate with sales teams to ensure timel...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Media

$140K - $155K *

Empower teams to elevate product design through strategic vision, fostering collaboration across disciplines to create impactful digital experiences that meet user needs and business goals while ensur...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$123K - $158K *

Unlock your potential by driving enterprise sales growth across the Americas. Collaborate with cross-functional teams to manage the full sales cycle, from prospecting to closing, while building strong...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Business Services

Frequently Asked Questions (FAQ)

  • What types of $100,000+ jobs can I find in Mississippi?question toggle

    Listings may include senior roles in healthcare, technology, manufacturing, finance, energy, engineering, and management. Opportunities change over time, so check current listings for available positions.

  • Which Mississippi cities have high-paying job opportunities?question toggle

    Professional opportunities may be listed in Jackson, Gulfport, Biloxi, Hattiesburg, Southaven, and other parts of the state, depending on employer hiring needs.

  • Are remote jobs available to Mississippi residents?question toggle

    Some employers offer remote or hybrid positions that may be open to Mississippi-based candidates. Review each listing to confirm location and work arrangement requirements.

  • How can I qualify for a $100,000+ job in Mississippi?question toggle

    Requirements vary by role. Employers commonly seek relevant experience, specialized skills, and a record of strong results; senior positions may also require leadership experience or advanced credentials.