Explore $100K+ Jobs in Mississippi

Discover professional opportunities in Mississippi with salaries of $100,000 or more. Ladders features vetted roles for experienced candidates seeking senior-level careers across the Magnolia State, from Jackson and the Gulf Coast to regional business hubs.

Mississippi Careers Across Industries

High-paying opportunities may be available in healthcare, technology, manufacturing, finance, energy, engineering, and executive leadership. Job availability and requirements vary by employer, location, and experience level, so review each listing for details.

Find Opportunities by Location

Search roles in Jackson, Gulfport, Biloxi, Hattiesburg, Southaven, and other Mississippi communities. You can also consider remote and hybrid positions with employers hiring professionals based in the state.

How to Search Mississippi Jobs on Ladders

Explore current listings, compare responsibilities and compensation details, and focus your search on roles that match your skills and career goals. Tailor your résumé to highlight measurable results, leadership experience, and relevant expertise when applying.

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1,000+

Jobs in Mississippi

Average Salary in USD

Average Salary: $110,974

Sort By: Relevance

$105K - $135K *

Join a team that's redefining digital agreement workflows and secure transactions. As a Mid-Level DocuSign/CLM Developer, you'll collaborate with stakeholders to enhance platform capabilities and deli...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Information Technology

$78K - $119K *

Lead a dynamic team of analysts to drive strategic insights and operational excellence across Revenue Operations. Collaborate with stakeholders, navigate complex challenges, and enhance analytical cap...

RemoteRemote

Reposted 1 week ago

  •   Less than 5 years exp.  •   Healthcare

$90K - $110K *

Drive comprehensive mental health care by assessing, diagnosing, and managing psychiatric disorders. Collaborate with multidisciplinary teams to create individualized treatment plans that enhance pati...

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$80K - $100K *

Transform multifamily renovation projects by leading teams, coordinating trades, and ensuring high-quality standards. Drive project success through effective management and proactive problem-solving w...

1 week ago

  •   5 - 7 years exp.  •   Real Estate & Construction

$160K - $200K *

Lead the charge in optimizing operations for a virtual clinic, enhancing service delivery and patient experience. Drive strategic initiatives and implement data-driven improvements to support families...

United StatesRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$110K - $130K *

Drive growth by promoting innovative regenerative medicine solutions. Leverage your expertise in vascular surgery sales and establish strong customer relationships to achieve targets and make a meanin...

United StatesRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$135K - $160K *

Reimagine cloud infrastructure as you build and operate scalable systems that empower product teams. Ensure reliability and speed in a dynamic environment, supporting enterprise-scale solutions for Fo...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Information Technology

$110K - $130K *

Drive client satisfaction as a Senior Project Manager, overseeing eDiscovery projects, managing budgets, and consulting on best practices. Lead teams, enhance workflows, and ensure timely delivery whi...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Legal & Accounting

$80K - $95K *

Provide expert technical support and solutions to enhance customer success with Mastercam products, collaborating with teams to optimize workflows and drive product improvements in the West region...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Manufacturing & Automotive

$110K - $130K *

Shape a world-class Supplier Quality Engineering team, enhancing vendor quality processes and driving a Zero Defect mentality. Collaborate across departments to ensure product conformity and foster a...

United StatesRemote

Reposted 1 week ago

  •   Less than 5 years exp.  •   Energy & Utilities

$160K - $192K *

Inspire commercial success by engaging healthcare providers and driving product adoption. Collaborate with cross-functional teams to support launches and optimize patient access, ensuring impactful re...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$112K - $196K *

Unlock potential by leading BIM initiatives and enhancing digital design workflows. Collaborate across teams to implement cutting-edge technologies, drive best practices, and support project delivery...

United StatesRemote

Reposted 1 week ago

  •   8 - 10 years exp.  •   Real Estate & Construction

$102K - $182K *

Lead the design and delivery of innovative clinical sales training programs for Structural Heart, enhancing sales team effectiveness and product knowledge through strategic curriculum development and...

United StatesRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Healthcare

$60K - $132K *

Elevate provider networks by managing complex contracts, enhancing compliance, and driving financial goals. Collaborate cross-functionally to optimize recruitment and negotiations, ensuring quality an...

RemoteRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$110K - $130K *

Champion innovative EBOS design solutions for utility-scale solar projects, ensuring compliance, manufacturability, and cost-efficiency while mentoring junior engineers and collaborating cross-functio...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Energy & Utilities

$105K - $140K *

Elevate your career by supporting mission-critical ColdFusion applications. Collaborate with diverse teams to enhance digital services, ensuring security and reliability while translating complex requ...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Information Technology

$114K - $140K *

Join a team that's transforming digital services by delivering innovative Salesforce solutions. Collaborate with stakeholders to enhance CRM capabilities, ensuring secure and efficient platform delive...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Information Technology

$120K - $145K *

Join a team that's transforming medicine by engaging with KOLs and healthcare professionals. Leverage your clinical expertise to communicate product benefits, support education, and drive strategic in...

United StatesRemote

Reposted 1 week ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$95K - $115K *

Join a dynamic legal team to manage contracts, compliance, and governance. Collaborate with leadership to enhance legal processes and mitigate risks in a fast-paced environment, making a significant i...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Energy & Utilities

$86K - $138K *

Champion the seamless member experience in healthcare access by defining product strategy and overseeing execution. Drive innovation in finding and scheduling care, ensuring accuracy and satisfaction...

RemoteRemote

Reposted 1 week ago

  •   Less than 5 years exp.  •   Healthcare

$160K - $180K *

Transform digital services by collaborating on Azure cloud engineering, CI/CD, and observability. Support mission-aligned platform capabilities while ensuring secure, reliable, and maintainable soluti...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Information Technology

$140K - $180K *

Unlock potential by leading digital transformation initiatives, leveraging open source and cloud technologies. Collaborate with cross-functional teams to enhance public sector solutions, ensuring clar...

United StatesRemote

Reposted 1 week ago

  •   Less than 5 years exp.  •   Information Technology

$85K - $120K *

Drive excellence in network operations by providing 24/7 support, designing solutions, and ensuring compliance with security best practices. Collaborate with teams to enhance customer connectivity and...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Information Technology

$190K - $267K *

Shape the future of app advertising by enhancing backend systems for conversion signals. Drive MMP integrations, SKAN processing, and App CAPI to ensure reliable app installs and in-app events for adv...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Media

$194K - $228K *

Lead the charge in sustainability as a senior executive, driving growth and innovation in occupier facilities management. Mentor teams, enhance client relationships, and spearhead strategic initiative...

United StatesRemote

Reposted 1 week ago

  •   11 - 15 years exp.  •   Real Estate & Construction

Frequently Asked Questions (FAQ)

  • What types of $100,000+ jobs can I find in Mississippi?question toggle

    Listings may include senior roles in healthcare, technology, manufacturing, finance, energy, engineering, and management. Opportunities change over time, so check current listings for available positions.

  • Which Mississippi cities have high-paying job opportunities?question toggle

    Professional opportunities may be listed in Jackson, Gulfport, Biloxi, Hattiesburg, Southaven, and other parts of the state, depending on employer hiring needs.

  • Are remote jobs available to Mississippi residents?question toggle

    Some employers offer remote or hybrid positions that may be open to Mississippi-based candidates. Review each listing to confirm location and work arrangement requirements.

  • How can I qualify for a $100,000+ job in Mississippi?question toggle

    Requirements vary by role. Employers commonly seek relevant experience, specialized skills, and a record of strong results; senior positions may also require leadership experience or advanced credentials.