Explore $100K+ Jobs in Mississippi

Discover professional opportunities in Mississippi with salaries of $100,000 or more. Ladders features vetted roles for experienced candidates seeking senior-level careers across the Magnolia State, from Jackson and the Gulf Coast to regional business hubs.

Mississippi Careers Across Industries

High-paying opportunities may be available in healthcare, technology, manufacturing, finance, energy, engineering, and executive leadership. Job availability and requirements vary by employer, location, and experience level, so review each listing for details.

Find Opportunities by Location

Search roles in Jackson, Gulfport, Biloxi, Hattiesburg, Southaven, and other Mississippi communities. You can also consider remote and hybrid positions with employers hiring professionals based in the state.

How to Search Mississippi Jobs on Ladders

Explore current listings, compare responsibilities and compensation details, and focus your search on roles that match your skills and career goals. Tailor your résumé to highlight measurable results, leadership experience, and relevant expertise when applying.

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1,000+

Jobs in Mississippi

Average Salary in USD

Average Salary: $110,974

Sort By: Relevance

$80K - $95K *

Grow your career with a strategic role focused on managing and expanding key B2B accounts. Drive customer satisfaction and retention through consultative program management, while collaborating with c...

United StatesRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Retail & Consumer Goods

$90K - $110K *

Advance your career by leveraging your MicroPact Versa expertise in a remote role focused on configuring regulatory COTS solutions for commercial and government sectors. Collaborate with teams in an a...

United StatesRemote

Reposted 1 week ago

  •   Less than 5 years exp.  •   Information Technology

$140K - $223K *

Unlock potential by bridging clinical practice with AI innovation. Collaborate with clinicians and engineers to enhance workflows and patient care through AI-driven imaging solutions in a hospital set...

RemoteRemote

1 week ago

  •   5 - 7 years exp.  •   Healthcare

$80K - $95K *

Elevate client success by crafting and optimizing innovative commerce media strategies. Leverage data-driven insights to enhance campaign performance across platforms, ensuring measurable growth and c...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Media

$110K - $130K *

Champion brand strategy for a diverse portfolio of university partners. Lead a team to develop positioning, messaging, and creative briefs, ensuring alignment across marketing functions while leveragi...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Education, Government & Non-Profit

$141K - $234K *

Lead the charge in healthcare performance improvement by overseeing project delivery, managing client relationships, and mentoring a team of Advisory consultants to ensure successful, high-quality out...

United StatesRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Healthcare

$202K - $250K *

Elevate the Personal Care department by driving strategic billing and claims initiatives, optimizing processes for accuracy and compliance, and leading a high-performing team to achieve operational ex...

United StatesRemote

1 week ago

  •   11 - 15 years exp.  •   Healthcare

$110K - $150K *

Unlock potential by leading claims adjudication logic to enhance accuracy and efficiency. Drive strategic improvements, collaborate across teams, and ensure compliance while optimizing operations in a...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Healthcare

$88K - $163K *

Help us optimize Workday integrations by configuring, testing, and delivering high-quality solutions across multiple projects. Collaborate with clients and teams to enhance processes and deepen your e...

RemoteRemote

1 week ago

  •   Less than 5 years exp.  •   Enterprise Technology

$162K - $244K *

Join a team that's driving channel success by building strong partnerships, creating impactful business plans, and enhancing pipeline growth through strategic collaboration and support for regional pa...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Information Technology

$120K - $145K *

Lead the charge in defining and activating brand strategies across multiple channels, enhancing donor engagement and retention through innovative content and social communications while collaborating...

RemoteRemote

1 week ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$106K - $160K *

Lead complex contract negotiations and drive strategic supplier relationships. Collaborate with stakeholders to assess risks, develop negotiation strategies, and enhance contracting practices while me...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Aerospace & Defense

$114K - $252K *

Unlock potential by leading software development initiatives, ensuring system integration, and guiding teams through agile methodologies to deliver high-quality solutions that meet customer requiremen...

United StatesRemote

1 week ago

  •   11 - 15 years exp.  •   Information Technology

$110K - $130K *

Lead and execute regulatory strategies for multi-region clinical trials, ensuring compliance and timely submissions. Collaborate with project teams to manage risks and drive operational excellence thr...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$118K - $180K *

Join a dynamic team enhancing nuclear power plants through advanced engineering. Leverage your expertise in thermodynamics and fluid mechanics to drive power uprate projects, mentor junior staff, and...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Technical Services

$100K - $152K *

Empower progress in environmental compliance by developing air permitting strategies for complex industrial projects. Collaborate with multi-disciplined teams to ensure adherence to air quality regula...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Technical Services

$145K - $222K *

Lead a structural engineering team, guiding projects for nuclear facilities. Utilize your expertise in design and analysis while collaborating with clients and multidisciplinary teams to deliver innov...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Technical Services

$132K - $174K *

Shape the future of environmental consulting by leading complex projects, fostering client relationships, and driving strategic initiatives. Collaborate with multidisciplinary teams to ensure excellen...

RemoteRemote

1 week ago

  •   11 - 15 years exp.  •   Energy & Utilities

$110K - $130K *

Elevate product execution by translating client needs into actionable requirements, collaborating with engineering and data science teams to deliver standardized measurement solutions across various c...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Information Technology

$89K - $113K *

Transform data integrity by assisting in the analysis and cleansing of Enterprise Business Systems. Collaborate with teams to resolve anomalies and ensure compliance with DoD standards while supportin...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Aerospace & Defense

$125K - $150K *

Shape the future of product marketing by bridging product and go-to-market teams. Drive impactful messaging, enablement, and strategies that resonate with audiences, ensuring alignment in a fast-paced...

RemoteRemote

1 week ago

  •   8 - 10 years exp.  •   Enterprise Technology

$115K - $150K *

Architect and streamline cloud network infrastructure. Support robust security and connectivity across Azure, OpenShift, and SASE platforms. Collaborate with cross-functional teams, ensuring optimal p...

United StatesRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Finance & Insurance

$95K - $158K *

Join a dedicated team to lead the software development efforts for private brand growth. Empower engineers to create innovative solutions while overseeing project delivery and fostering a collaborativ...

United StatesRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Retail & Consumer Goods

$142K - $178K *

Lead the charge in strategic financial planning, driving insights and forecasts that shape growth. Collaborate with executives and teams to enhance financial models and reporting processes in a dynami...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Enterprise Technology

$120K - $145K *

Join a dynamic finance team as you oversee financial reporting, manage reconciliations, and enhance accounting processes. Your expertise will ensure compliance with GAAP while supporting audits and op...

United StatesRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Healthcare

Frequently Asked Questions (FAQ)

  • What types of $100,000+ jobs can I find in Mississippi?question toggle

    Listings may include senior roles in healthcare, technology, manufacturing, finance, energy, engineering, and management. Opportunities change over time, so check current listings for available positions.

  • Which Mississippi cities have high-paying job opportunities?question toggle

    Professional opportunities may be listed in Jackson, Gulfport, Biloxi, Hattiesburg, Southaven, and other parts of the state, depending on employer hiring needs.

  • Are remote jobs available to Mississippi residents?question toggle

    Some employers offer remote or hybrid positions that may be open to Mississippi-based candidates. Review each listing to confirm location and work arrangement requirements.

  • How can I qualify for a $100,000+ job in Mississippi?question toggle

    Requirements vary by role. Employers commonly seek relevant experience, specialized skills, and a record of strong results; senior positions may also require leadership experience or advanced credentials.