Explore $100K+ Jobs in Mississippi

Discover professional opportunities in Mississippi with salaries of $100,000 or more. Ladders features vetted roles for experienced candidates seeking senior-level careers across the Magnolia State, from Jackson and the Gulf Coast to regional business hubs.

Mississippi Careers Across Industries

High-paying opportunities may be available in healthcare, technology, manufacturing, finance, energy, engineering, and executive leadership. Job availability and requirements vary by employer, location, and experience level, so review each listing for details.

Find Opportunities by Location

Search roles in Jackson, Gulfport, Biloxi, Hattiesburg, Southaven, and other Mississippi communities. You can also consider remote and hybrid positions with employers hiring professionals based in the state.

How to Search Mississippi Jobs on Ladders

Explore current listings, compare responsibilities and compensation details, and focus your search on roles that match your skills and career goals. Tailor your résumé to highlight measurable results, leadership experience, and relevant expertise when applying.

Remote
caret down
Compensation
caret down
Position Level
caret down
Time Posted
caret down
Industries
caret down
Locations
caret down
More
1
caret down
1,000+

Jobs in Mississippi

Average Salary in USD

Average Salary: $110,974

Sort By: Relevance

$131K - $200K *

Join a team that's shaping the future of data platforms by developing scalable solutions for analytics and AI workloads. Collaborate on impactful projects using cutting-edge tools to enhance data reli...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Healthcare

$73K - $115K *

Grow your career with a dynamic team focused on optimizing provider operations. Lead credentialing initiatives, implement AI solutions, and enhance workflows while ensuring compliance and operational...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$73K - $115K *

Help us drive operational excellence in provider data management, ensuring accuracy and efficiency throughout the lifecycle. Collaborate with teams to enhance processes, leverage insights, and impleme...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$58K - $105K *

Unlock your potential by managing the full contracting lifecycle, supporting critical agreements for Medicare Advantage and Commercial operations, while collaborating with diverse teams to enhance com...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Healthcare

$80K - $95K *

Shape the future of brand strategy by crafting distinct messaging and positioning for a diverse portfolio of university partners. Collaborate with cross-functional teams to optimize campaigns and enha...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Education, Government & Non-Profit

$90K - $150K *

Lead the charge in transforming healthcare systems through data-driven insights and collaborative engagement. Drive performance improvement by managing analytics projects, delivering client solutions...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$80K - $95K *

Advance your career by driving impactful Paid Social strategies across platforms like Meta and TikTok. Collaborate with cross-functional teams to optimize campaigns, leverage data insights, and enhanc...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Media

$202K - $250K *

Champion data-driven decision-making by leading the development of integrated analytics and reporting strategies. Drive operational efficiency and financial performance through innovative data solutio...

United StatesRemote

1 week ago

  •   11 - 15 years exp.  •   Healthcare

$105K - $120K *

Join a dynamic team to lead and enhance information security programs, ensuring compliance and risk management across diverse industries. Collaborate with executives to develop strategies that protect...

RemoteRemote

1 week ago

  •   5 - 7 years exp.  •   Aerospace & Defense

$160K - $185K *

Lead the charge in developing compelling proposals for government contracts, managing the entire proposal process from strategy to submission. Collaborate with cross-functional teams to ensure complia...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Technical Services

$110K - $130K *

Take ownership of comprehensive cyber risk assessments across the enterprise, articulating risks in business terms to ensure informed decision-making by leadership and helping to strengthen the organi...

United StatesRemote

Reposted 1 week ago

  •   8 - 10 years exp.  •   Technical Services

$85K - $113K *

Elevate patient care by collaborating with a multidisciplinary team, developing tailored care plans, and ensuring compliance with health regulations while utilizing EHR systems effectively to enhance...

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$78K - $113K *

Unlock potential by leading complex revenue cycle projects, providing analytical support, and collaborating across departments to enhance billing processes and resolve financial issues in a fast-paced...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$110K *

Champion the clinical operations team, ensuring project success through resource management, process efficiencies, and compliance. Drive training, metrics development, and mentorship to enhance team c...

United StatesRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$90K - $190K *

Unlock potential by serving as a functional SME in Workday solutions, advising and configuring systems to meet client needs. Balance multiple projects while ensuring timely issue resolution and delive...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Enterprise Technology

$90K - $110K *

Join our new Data Engineering team to lead business intelligence initiatives, build trusted data models in Snowflake, and deliver impactful reports in Power BI. Collaborate with stakeholders to enhanc...

RemoteRemote

1 week ago

  •   Less than 5 years exp.  •   Education, Government & Non-Profit

$100K - $120K *

Champion endpoint strategy and governance, leading a specialized team to deliver secure, scalable services across diverse devices. Collaborate with IT and business leaders to drive automation, operati...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Finance & Insurance

$75K - $115K *

Innovate in cybersecurity as you drive technical conversations and deliver tailored solutions. Collaborate with sales teams to enhance customer relationships and showcase the unique value of next-gen...

RemoteRemote

1 week ago

  •   Less than 5 years exp.  •   Information Technology

$85K - $128K *

Unlock potential by driving cloud security sales initiatives, collaborating with teams, establishing partnerships with key personas, and engaging customers to integrate innovative security solutions i...

United StatesRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Information Technology

$77K - $118K *

Transform network operations by designing and implementing automation solutions that enhance reliability and efficiency across multi-vendor infrastructures, utilizing advanced technologies like Python...

United StatesRemote

Reposted 1 week ago

  •   Less than 5 years exp.  •   Information Technology

$77K - $118K *

Drive the evolution of scalable, secure platforms by architecting solutions that enhance network intelligence and application delivery, collaborating with cross-functional teams to optimize performanc...

United StatesRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Information Technology

$174K - $234K *

Champion the development and governance of global transfer pricing strategies, ensuring alignment with business operations and compliance across jurisdictions while leading cross-functional collaborat...

United StatesRemote

1 week ago

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

$204K - $274K *

Champion the U.S. Biologics Regulatory CMC team by providing strategic leadership, ensuring timely regulatory submissions, and fostering collaboration among global stakeholders to drive innovative bio...

United StatesRemote

Reposted 1 week ago

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

$167K - $300K *

Unlock your potential by leading regional oncology thought leader engagement and advocacy strategies. Collaborate with cross-functional teams to shape brand strategy and launch planning for innovative...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$167K - $300K *

Elevate oncology marketing strategies by leading KOL engagement and advocacy initiatives. Utilize market insights to shape brand strategy and launch planning for innovative therapies, ensuring complia...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

Frequently Asked Questions (FAQ)

  • What types of $100,000+ jobs can I find in Mississippi?question toggle

    Listings may include senior roles in healthcare, technology, manufacturing, finance, energy, engineering, and management. Opportunities change over time, so check current listings for available positions.

  • Which Mississippi cities have high-paying job opportunities?question toggle

    Professional opportunities may be listed in Jackson, Gulfport, Biloxi, Hattiesburg, Southaven, and other parts of the state, depending on employer hiring needs.

  • Are remote jobs available to Mississippi residents?question toggle

    Some employers offer remote or hybrid positions that may be open to Mississippi-based candidates. Review each listing to confirm location and work arrangement requirements.

  • How can I qualify for a $100,000+ job in Mississippi?question toggle

    Requirements vary by role. Employers commonly seek relevant experience, specialized skills, and a record of strong results; senior positions may also require leadership experience or advanced credentials.