Explore $100K+ Jobs in Mississippi

Discover professional opportunities in Mississippi with salaries of $100,000 or more. Ladders features vetted roles for experienced candidates seeking senior-level careers across the Magnolia State, from Jackson and the Gulf Coast to regional business hubs.

Mississippi Careers Across Industries

High-paying opportunities may be available in healthcare, technology, manufacturing, finance, energy, engineering, and executive leadership. Job availability and requirements vary by employer, location, and experience level, so review each listing for details.

Find Opportunities by Location

Search roles in Jackson, Gulfport, Biloxi, Hattiesburg, Southaven, and other Mississippi communities. You can also consider remote and hybrid positions with employers hiring professionals based in the state.

How to Search Mississippi Jobs on Ladders

Explore current listings, compare responsibilities and compensation details, and focus your search on roles that match your skills and career goals. Tailor your résumé to highlight measurable results, leadership experience, and relevant expertise when applying.

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1,000+

Jobs in Mississippi

Average Salary in USD

Average Salary: $111,580

Sort By: Relevance

$85K - $130K *

Champion innovative control systems for industrial solutions, leading design and development projects. Collaborate with teams to ensure products meet market demands while transitioning designs to manu...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$110K - $130K *

Empower a team of controls engineers to design and enhance control systems for material handling solutions, ensuring project execution and quality while fostering innovation and collaboration across d...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Manufacturing & Automotive

$125K - $145K *

Champion the future of financial reporting by ensuring compliance with GAAP, overseeing audits, and mentoring a high-performing team. Drive process improvements and technical accounting expertise to e...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Healthcare

$95K *

Lead the charge in auditing inpatient claims, ensuring coding accuracy and clinical validation. Utilize advanced coding expertise to analyze claims independently, while meeting productivity and qualit...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Healthcare

$110K - $130K *

Optimize the Innovation portfolio by leading high-impact projects, collaborating with senior leaders, and driving strategic initiatives. Your role will ensure seamless operations and foster growth in...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Healthcare

$90K - $140K *

Join a dynamic team to lead complex data management projects, blending Agile methodologies with technical expertise. Drive collaboration across healthcare analytics, ensuring successful delivery and s...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Legal & Accounting

$150K - $180K *

Lead a high-performing sales team to drive new logo acquisition and revenue growth in enterprise software. Develop strategies, foster collaboration, and engage executive customers to expand market sha...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Enterprise Technology

$110K - $130K *

Lead the transformation of healthcare IT by managing ServiceNow projects, enhancing workflows, and ensuring seamless integration. Collaborate with cross-functional teams to deliver innovative solution...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Healthcare

$120K - $175K *

Join a team that's dedicated to managing complex professional liability claims, focusing on legal malpractice. Leverage your expertise to evaluate coverage, negotiate outcomes, and ensure timely reser...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Finance & Insurance

$126K - $236K *

Lead the charge in consumer engagement and growth strategy, driving awareness and deepening user connections across channels. Collaborate cross-functionally to optimize campaigns that inspire action a...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Media

$90K - $110K *

Join a team that's driving enterprise growth by building relationships and closing new business. This proactive sales role focuses on acquiring customers for innovative workforce development solutions...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Education, Government & Non-Profit

$275K - $340K *

Drive growth by leading sales and customer success teams, refining strategies, and optimizing processes. Shape the commercial landscape while mentoring talent and ensuring high-value customer relation...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Media

$199K - $269K *

Shape patient affordability strategies by leading a dynamic team focused on co-pay programs and innovative solutions. Collaborate cross-functionally to enhance operations, optimize performance, and dr...

United StatesRemote

Reposted 1 week ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$191K - $258K *

Shape the future of global safety by leading the development and submission of periodic aggregate safety reports. Drive compliance and collaboration across teams while managing a diverse global team t...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$85K - $100K *

Deliver advanced field service support for Promega instrumentation, ensuring installation, training, and repairs meet customer service standards. Collaborate with teams to enhance service documentatio...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$317K - $443K *

Engage with cross-functional teams to shape the design vision for search and feeds, leading a talented design group to enhance user discovery and community connections while driving growth and retenti...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Media

$80K - $95K *

Join a team that's dedicated to enhancing automation solutions through troubleshooting, programming, and customer collaboration. Leverage your skills to improve machinery performance and ensure seamle...

RemoteRemote

Reposted 1 week ago

  •   Less than 5 years exp.  •   Manufacturing & Automotive

$100K - $120K *

Champion the operation and maintenance of a high-reliability power plant, leading a diverse team to ensure optimal performance and safety standards while supporting critical AI supercomputing faciliti...

1 week ago

  •   5 - 7 years exp.  •   Information Technology

$245K - $290K *

Champion strategic relationships in community oncology to enhance market access for innovative therapies. Drive account strategies, negotiate contracts, and collaborate cross-functionally to ensure op...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$80K - $95K *

Shape the future of client solutions by leading technical discovery and crafting innovative data-driven strategies. Collaborate with sales teams to drive success and ensure seamless implementation of...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Technical Services

$80K - $95K *

Drive excellence by leading a manufacturing team to enhance product quality and customer satisfaction while ensuring safety and efficiency across multiple shifts...

Reposted 1 week ago

  •   Less than 5 years exp.  •   Manufacturing & Automotive

$80K - $95K *

Champion the deployment of cutting-edge AI systems in diverse environments. Collaborate with teams to ensure seamless installation and operation of hardware and software, while providing exceptional c...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Enterprise Technology

$242K - $290K *

Empower strategic partnerships by managing alliances, driving collaboration, and ensuring alignment with organizational goals. Leverage your expertise to foster trust and deliver impactful outcomes in...

United StatesRemote

1 week ago

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

$110K - $160K *

Optimize customer networks while delivering integrated networking and cybersecurity solutions. Collaborate globally, enhance performance, and ensure satisfaction as you tackle complex challenges in an...

United StatesRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Telecommunications & Hardware

$100K - $120K *

Lead the monthly close and day-to-day accounting operations, ensuring accuracy and efficiency as the business scales. Collaborate with cross-functional teams to enhance processes and implement automat...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Enterprise Technology

Frequently Asked Questions (FAQ)

  • What types of $100,000+ jobs can I find in Mississippi?question toggle

    Listings may include senior roles in healthcare, technology, manufacturing, finance, energy, engineering, and management. Opportunities change over time, so check current listings for available positions.

  • Which Mississippi cities have high-paying job opportunities?question toggle

    Professional opportunities may be listed in Jackson, Gulfport, Biloxi, Hattiesburg, Southaven, and other parts of the state, depending on employer hiring needs.

  • Are remote jobs available to Mississippi residents?question toggle

    Some employers offer remote or hybrid positions that may be open to Mississippi-based candidates. Review each listing to confirm location and work arrangement requirements.

  • How can I qualify for a $100,000+ job in Mississippi?question toggle

    Requirements vary by role. Employers commonly seek relevant experience, specialized skills, and a record of strong results; senior positions may also require leadership experience or advanced credentials.