Explore $100K+ Jobs in Mississippi

Discover professional opportunities in Mississippi with salaries of $100,000 or more. Ladders features vetted roles for experienced candidates seeking senior-level careers across the Magnolia State, from Jackson and the Gulf Coast to regional business hubs.

Mississippi Careers Across Industries

High-paying opportunities may be available in healthcare, technology, manufacturing, finance, energy, engineering, and executive leadership. Job availability and requirements vary by employer, location, and experience level, so review each listing for details.

Find Opportunities by Location

Search roles in Jackson, Gulfport, Biloxi, Hattiesburg, Southaven, and other Mississippi communities. You can also consider remote and hybrid positions with employers hiring professionals based in the state.

How to Search Mississippi Jobs on Ladders

Explore current listings, compare responsibilities and compensation details, and focus your search on roles that match your skills and career goals. Tailor your résumé to highlight measurable results, leadership experience, and relevant expertise when applying.

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1,000+

Jobs in Mississippi

Average Salary in USD

Average Salary: $111,580

Sort By: Relevance

$88K - $105K *

Join a dynamic team to ensure compliance with healthcare quality standards, manage credentialing databases, and support operational objectives. Collaborate across departments to enhance quality govern...

United StatesRemote

5 days ago

  •   5 - 7 years exp.  •   Hospitals & Medical Centers

$300K - $350K *

Empower your career by driving sales growth in the cybersecurity sector. Build strong customer relationships, acquire new accounts, and exceed sales quotas while managing Channel Partner relationships...

United StatesRemote

5 days ago

  •   5 - 7 years exp.  •   Information Technology

$300K - $350K *

Accelerate progress at driving sales growth in the cybersecurity sector by acquiring new accounts, building relationships, and ensuring customer satisfaction. Leverage your expertise to exceed quotas...

United StatesRemote

5 days ago

  •   5 - 7 years exp.  •   Information Technology

$195K - $265K *

Transform global marketing strategies in oncology by leading cross-functional teams, driving insights, and optimizing brand value for pipeline assets. Collaborate with stakeholders to enhance commerci...

United StatesRemote

5 days ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$110K - $130K *

Unlock potential by driving business development in Electronic Warfare, managing relationships with US DoD customers, and expanding market presence through strategic sales initiatives and customer eng...

United StatesRemote

5 days ago

  •   8 - 10 years exp.  •   Aerospace & Defense

$106K - $214K *

Join a team that's dedicated to enhancing cybersecurity through proactive incident response, threat analysis, and collaboration across various DHS components, ensuring the safety and integrity of nati...

5 days ago

  •   5 - 7 years exp.  •   Education, Government & Non-Profit

$150K - $180K *

Lead the charge in shaping pricing strategy for a key region, overseeing a talented team to drive profitable growth while navigating complex regulatory environments and leveraging data for strategic d...

United StatesRemote

Reposted 5 days ago

  •   8 - 10 years exp.  •   Finance & Insurance

$172K - $211K *

Drive the development of innovative earned-revenue strategies that enhance mission impact and financial sustainability. Collaborate with cross-functional teams to identify, test, and scale viable busi...

United StatesRemote

5 days ago

  •   11 - 15 years exp.  •   Enterprise Technology

$110K - $130K *

Join a team that's dedicated to delivering innovative eDiscovery solutions. Collaborate with cross-functional teams to manage client relationships, oversee project execution, and provide expert guidan...

United StatesRemote

5 days ago

  •   5 - 7 years exp.  •   Legal & Accounting

$80K - $95K *

Champion operational excellence by overseeing regional profitability, managing staffing efficiencies, and driving performance improvements. Collaborate with management to achieve financial goals and e...

United StatesRemote

5 days ago

  •   Less than 5 years exp.  •   Healthcare

$80K - $95K *

Transform healthcare by leading nursing teams, managing budgets, and enhancing resident care. Collaborate with stakeholders to implement best practices and foster professional growth in a supportive e...

5 days ago

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$80K - $95K *

Join a dynamic team to oversee business operations, financial planning, and resource management. Lead and coordinate departmental activities while ensuring compliance and enhancing productivity throug...

5 days ago

  •   5 - 7 years exp.  •   Healthcare

$110K - $124K *

Transform the future of AI education by mentoring fellows through their journey, guiding them in technical and organizational challenges while fostering their professional growth across diverse host o...

United StatesRemote

5 days ago

  •   Less than 5 years exp.  •   Education, Government & Non-Profit

$130K - $145K *

Champion data privacy across jurisdictions by providing expert advice, managing compliance, and supporting initiatives within a global team. Collaborate with colleagues to ensure lawful handling of pe...

United StatesRemote

5 days ago

  •   Less than 5 years exp.  •   Finance & Insurance

$125K - $150K *

Transform complex customer implementations into seamless successes by owning the delivery lifecycle, driving technical discussions, and ensuring stakeholder satisfaction from kickoff to go-live. Your...

United StatesRemote

5 days ago

  •   5 - 7 years exp.  •   Healthcare

$105K - $120K *

Drive client success by managing utility and energy efficiency programs, ensuring satisfaction, fostering relationships, and identifying growth opportunities while delivering on contractual obligation...

United StatesRemote

Reposted 5 days ago

  •   Less than 5 years exp.  •   Energy & Utilities

$80K - $95K *

Analyze labor market data and audience behaviors to develop actionable insights that enhance recruitment marketing strategies. Collaborate with cross-functional teams to create data-driven audience pe...

United StatesRemote

5 days ago

  •   5 - 7 years exp.  •   Business Services

$105K - $141K *

Contribute to the development of data and tooling capabilities that drive GTM growth strategies. Collaborate across teams to translate business needs into scalable solutions, enhancing marketing and r...

United StatesRemote

5 days ago

  •   5 - 7 years exp.  •   Telecommunications & Hardware

$80K - $95K *

Lead the charge in managing site operations and vendor relations, ensuring compliance and efficiency in clinical research projects. Collaborate with teams to streamline processes and enhance training...

United StatesRemote

5 days ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$230K - $275K *

Join a team that's redefining B2B sales by leading and mentoring a high-performing regional team while driving significant revenue growth and building a vibrant sales culture in a rapidly scaling envi...

United StatesRemote

Reposted 5 days ago

  •   5 - 7 years exp.  •   Retail & Consumer Goods

$135K - $160K *

Champion the transformation of web initiatives into impactful projects, overseeing the entire lifecycle from planning to launch. Collaborate with cross-functional teams to enhance user experience and...

United StatesRemote

5 days ago

  •   8 - 10 years exp.  •   Information Technology

$80K - $95K *

Engage in proactive case management and litigation for civil defense, utilizing strong research and communication skills to deliver exceptional client service and strategic legal analysis in both stat...

5 days ago

  •   Less than 5 years exp.  •   Legal & Accounting

$100K - $120K *

Accelerate progress at driving new business growth in IP services by engaging corporate IP departments and legal teams. Leverage consultative selling to expand accounts and build lasting relationships...

United StatesRemote

5 days ago

  •   Less than 5 years exp.  •   Legal & Accounting

$72K - $120K *

Unlock your potential by leading creative strategy and visual design initiatives. Drive brand evolution and campaign execution while mentoring teams to enhance the College Board's visual identity acro...

United StatesRemote

5 days ago

  •   8 - 10 years exp.  •   Education, Government & Non-Profit

$140K - $150K *

Shape the future of foodservice by leading strategic account growth with top chains. Drive market penetration, manage key relationships, and develop actionable plans to enhance profitability and expan...

RemoteRemote

5 days ago

  •   5 - 7 years exp.  •   Food & Beverages

Frequently Asked Questions (FAQ)

  • What types of $100,000+ jobs can I find in Mississippi?question toggle

    Listings may include senior roles in healthcare, technology, manufacturing, finance, energy, engineering, and management. Opportunities change over time, so check current listings for available positions.

  • Which Mississippi cities have high-paying job opportunities?question toggle

    Professional opportunities may be listed in Jackson, Gulfport, Biloxi, Hattiesburg, Southaven, and other parts of the state, depending on employer hiring needs.

  • Are remote jobs available to Mississippi residents?question toggle

    Some employers offer remote or hybrid positions that may be open to Mississippi-based candidates. Review each listing to confirm location and work arrangement requirements.

  • How can I qualify for a $100,000+ job in Mississippi?question toggle

    Requirements vary by role. Employers commonly seek relevant experience, specialized skills, and a record of strong results; senior positions may also require leadership experience or advanced credentials.