Discover professional opportunities in Mississippi with salaries of $100,000 or more. Ladders features vetted roles for experienced candidates seeking senior-level careers across the Magnolia State, from Jackson and the Gulf Coast to regional business hubs.
High-paying opportunities may be available in healthcare, technology, manufacturing, finance, energy, engineering, and executive leadership. Job availability and requirements vary by employer, location, and experience level, so review each listing for details.
Search roles in Jackson, Gulfport, Biloxi, Hattiesburg, Southaven, and other Mississippi communities. You can also consider remote and hybrid positions with employers hiring professionals based in the state.
Explore current listings, compare responsibilities and compensation details, and focus your search on roles that match your skills and career goals. Tailor your résumé to highlight measurable results, leadership experience, and relevant expertise when applying.
Average Salary: $110,974
Director Security Infrastructure & Engineering
$138K - $200K *
Drive the strategic direction of enterprise security infrastructure, leading teams to design, implement, and optimize security solutions across on-premises, cloud, and hybrid environments while ensuri...
5 days ago
Senior Partner AI Enablement Manager
$125K - $150K *
Accelerate progress at building a world-class AI Receptionist partner ecosystem, driving revenue and customer success through strategic enablement programs. Collaborate cross-functionally to enhance p...
5 days ago
Customer Success Manager, Enterprise
$92K - $139K *
Drive exceptional customer success by managing a complex portfolio of Enterprise accounts, enhancing software value through strategic relationships and problem-solving. Influence industry revenue and...
Reposted 5 days ago
Nurse Practitioner - Express Care Sumrall - Full Time
$90K - $110K *
Elevate patient care by diagnosing illnesses, prescribing treatments, and coordinating health plans. Collaborate with healthcare teams to ensure comprehensive patient assessments and promote health th...
5 days ago
$105K - $150K *
Transform your career by joining a dynamic team focused on enhancing security compliance for cloud services. Leverage your expertise in IT security to assess architectures, guide vendors, and ensure a...
5 days ago
Senior Principal - Business Consulting
$210K - $256K *
Unlock potential by leading strategic payment modernization efforts, managing client relationships, and delivering complex digital solutions while collaborating across teams to enhance operational eff...
Reposted 5 days ago
$73K - $102K *
Join a dynamic team to enhance software solutions through coding, testing, and collaboration. Contribute to design discussions, maintain code quality, and ensure seamless transitions to new applicatio...
5 days ago
$100K - $120K *
Join a team that's dedicated to enhancing patient care through empathetic pharmacy consulting, medication management, and operational excellence. Lead pharmacy staff, ensure compliance, and improve pa...
5 days ago
$100K - $120K *
Empower patients through expert pharmacy consulting and clinical services. Manage pharmacy operations, enhance patient experiences, and lead staff development while ensuring compliance with regulation...
5 days ago
Senior Systems & Security Engineer
$110K - $130K *
Empower our IT environment by enhancing security and reliability through hands-on systems engineering, cybersecurity, and incident response. Collaborate across teams to design, implement, and manage s...
5 days ago
Senior Staff Software Engineer - Identity & Trust
$238K - $341K *
Pioneer secure identity solutions by architecting a robust Identity & Trust platform. Lead multi-year strategies, drive high-impact initiatives, and mentor engineers to enhance customer onboarding and...
5 days ago
Commercial Account Executive (Enterprise)
$110K - $130K *
Champion enterprise growth by driving strategic account expansion and retention. Collaborate with cross-functional teams to influence executive stakeholders and execute complex sales strategies, ensur...
Reposted 5 days ago
Business Development Executive
$100K - $120K *
Drive new logo acquisition and revenue growth by managing the full sales cycle for assigned prospects, leveraging industry expertise and consultative selling to deliver tailored solutions and achieve...
Reposted 5 days ago
$95K - $115K *
Join a team that's transforming sales enablement by bridging insights and execution. Leverage market data and expertise to empower client engagement teams, enhance discovery processes, and drive effec...
5 days ago
Director, Transformation & AI Enablement
$181K - $208K *
Drive enterprise transformation and AI adoption by leading cross-functional teams, aligning strategic priorities with measurable outcomes, and fostering collaboration across business and technology se...
5 days ago
$95K - $159K *
Unlock potential by joining a dynamic web engineering team to design, develop, and maintain scalable applications. Collaborate with cross-functional teams, mentor engineers, and enhance CI/CD practice...
Reposted 5 days ago
Customer Success Partner- Healthcare Vertical
$75K - $90K *
Engage with strategic accounts to drive revenue growth through consultative sales and account management. Develop and maintain account plans, coordinate resources, and ensure customer satisfaction whi...
Reposted 5 days ago
Managing Consultant, Strategic Advisory
$118K - $178K *
Shape strategic initiatives by leading key deliverables and financial analyses. Collaborate with partners to enhance business processes and drive impactful recommendations, ensuring alignment and time...
5 days ago
$125K - $150K *
Lead the charge in driving scalable revenue growth through integrated demand generation and digital marketing strategies. Collaborate with cross-functional teams to optimize marketing operations and e...
5 days ago
$174K - $250K *
Drive your career forward by partnering with executives to shape AI strategies, lead complex architecture discussions, and deliver tailored solutions that enhance enterprise AI ecosystems and revenue...
5 days ago
Head of A/R, Credit & Financing Solutions.
$150K - $170K *
Take ownership of strategic finance leadership, optimizing cash flow and credit risk while developing innovative financing solutions to drive profitable growth and enhance operational efficiency acros...
5 days ago
Vice President of Technology (US, Remote)
$170K - $220K *
Lead the charge in technology strategy and execution, overseeing software engineering, business systems, and IT. Drive innovation and efficiency while ensuring robust architecture and team development...
5 days ago
Program Manager, National Security - DHS
$145K - $175K *
Transform customer success by managing DHS accounts through the entire lifecycle, ensuring seamless delivery, adoption, and growth of Skydio systems while collaborating with cross-functional teams to...
5 days ago
Manager, Sales Recruiting (AMER)
$104K - $176K *
Lead and develop a high-performing Sales recruiting team across the Americas. Partner with Sales leaders to design scalable hiring strategies, enhance candidate experience, and drive revenue growth th...
5 days ago
Senior DevSecOps / Platform Engineer
$112K - $179K *
Champion the Agentic AI platform by owning its end-to-end operations, ensuring secure, reliable, and scalable delivery through advanced CI/CD practices, AWS infrastructure, and Kubernetes management...
Reposted 5 days ago
What types of $100,000+ jobs can I find in Mississippi?
Listings may include senior roles in healthcare, technology, manufacturing, finance, energy, engineering, and management. Opportunities change over time, so check current listings for available positions.
Which Mississippi cities have high-paying job opportunities?
Professional opportunities may be listed in Jackson, Gulfport, Biloxi, Hattiesburg, Southaven, and other parts of the state, depending on employer hiring needs.
Are remote jobs available to Mississippi residents?
Some employers offer remote or hybrid positions that may be open to Mississippi-based candidates. Review each listing to confirm location and work arrangement requirements.
How can I qualify for a $100,000+ job in Mississippi?
Requirements vary by role. Employers commonly seek relevant experience, specialized skills, and a record of strong results; senior positions may also require leadership experience or advanced credentials.