Explore $100K+ Jobs in Mississippi

Discover professional opportunities in Mississippi with salaries of $100,000 or more. Ladders features vetted roles for experienced candidates seeking senior-level careers across the Magnolia State, from Jackson and the Gulf Coast to regional business hubs.

Mississippi Careers Across Industries

High-paying opportunities may be available in healthcare, technology, manufacturing, finance, energy, engineering, and executive leadership. Job availability and requirements vary by employer, location, and experience level, so review each listing for details.

Find Opportunities by Location

Search roles in Jackson, Gulfport, Biloxi, Hattiesburg, Southaven, and other Mississippi communities. You can also consider remote and hybrid positions with employers hiring professionals based in the state.

How to Search Mississippi Jobs on Ladders

Explore current listings, compare responsibilities and compensation details, and focus your search on roles that match your skills and career goals. Tailor your résumé to highlight measurable results, leadership experience, and relevant expertise when applying.

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1,000+

Jobs in Mississippi

Average Salary in USD

Average Salary: $110,974

Sort By: Relevance

$80K - $95K *

Champion cross-functional projects to enhance operational efficiency and achieve organizational goals. Lead initiatives from planning to completion, ensuring timely delivery within scope and budget wh...

United StatesRemote

5 days ago

  •   Less than 5 years exp.  •   Healthcare

$180K - $200K *

Drive the future of AI capability by leading the development of role-specific tools and workflows, ensuring measurable impact and adoption across teams. Collaborate with HR to enhance learning and ope...

United StatesRemote

5 days ago

  •   5 - 7 years exp.  •   Real Estate & Construction

$138K - $200K *

Drive the strategic direction of enterprise security infrastructure, leading teams to design, implement, and optimize security solutions across on-premises, cloud, and hybrid environments while ensuri...

United StatesRemote

5 days ago

  •   5 - 7 years exp.  •   Finance & Insurance

$125K - $150K *

Accelerate progress at building a world-class AI Receptionist partner ecosystem, driving revenue and customer success through strategic enablement programs. Collaborate cross-functionally to enhance p...

United StatesRemote

5 days ago

  •   5 - 7 years exp.  •   Information Technology

$92K - $139K *

Drive exceptional customer success by managing a complex portfolio of Enterprise accounts, enhancing software value through strategic relationships and problem-solving. Influence industry revenue and...

RemoteRemote

Reposted 5 days ago

  •   Less than 5 years exp.  •   Information Technology

$90K - $110K *

Elevate patient care by diagnosing illnesses, prescribing treatments, and coordinating health plans. Collaborate with healthcare teams to ensure comprehensive patient assessments and promote health th...

5 days ago

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$105K - $150K *

Transform your career by joining a dynamic team focused on enhancing security compliance for cloud services. Leverage your expertise in IT security to assess architectures, guide vendors, and ensure a...

United StatesRemote

5 days ago

  •   5 - 7 years exp.  •   Information Technology

$210K - $256K *

Unlock potential by leading strategic payment modernization efforts, managing client relationships, and delivering complex digital solutions while collaborating across teams to enhance operational eff...

United StatesRemote

Reposted 5 days ago

  •   8 - 10 years exp.  •   Information Technology

$73K - $102K *

Join a dynamic team to enhance software solutions through coding, testing, and collaboration. Contribute to design discussions, maintain code quality, and ensure seamless transitions to new applicatio...

United StatesRemote

5 days ago

  •   Less than 5 years exp.  •   Information Technology

$100K - $120K *

Join a team that's dedicated to enhancing patient care through empathetic pharmacy consulting, medication management, and operational excellence. Lead pharmacy staff, ensure compliance, and improve pa...

5 days ago

  •   Less than 5 years exp.  •   Retail & Consumer Goods

$100K - $120K *

Empower patients through expert pharmacy consulting and clinical services. Manage pharmacy operations, enhance patient experiences, and lead staff development while ensuring compliance with regulation...

5 days ago

  •   Less than 5 years exp.  •   Retail & Consumer Goods

$110K - $130K *

Empower our IT environment by enhancing security and reliability through hands-on systems engineering, cybersecurity, and incident response. Collaborate across teams to design, implement, and manage s...

United StatesRemote

5 days ago

  •   Less than 5 years exp.  •   Legal & Accounting

$238K - $341K *

Pioneer secure identity solutions by architecting a robust Identity & Trust platform. Lead multi-year strategies, drive high-impact initiatives, and mentor engineers to enhance customer onboarding and...

United StatesRemote

5 days ago

  •   8 - 10 years exp.  •   Finance & Insurance

$110K - $130K *

Champion enterprise growth by driving strategic account expansion and retention. Collaborate with cross-functional teams to influence executive stakeholders and execute complex sales strategies, ensur...

United StatesRemote

Reposted 5 days ago

  •   5 - 7 years exp.  •   Information Technology

$100K - $120K *

Drive new logo acquisition and revenue growth by managing the full sales cycle for assigned prospects, leveraging industry expertise and consultative selling to deliver tailored solutions and achieve...

United StatesRemote

Reposted 5 days ago

  •   5 - 7 years exp.  •   Information Technology

$95K - $115K *

Join a team that's transforming sales enablement by bridging insights and execution. Leverage market data and expertise to empower client engagement teams, enhance discovery processes, and drive effec...

United StatesRemote

5 days ago

  •   5 - 7 years exp.  •   Finance & Insurance

$181K - $208K *

Drive enterprise transformation and AI adoption by leading cross-functional teams, aligning strategic priorities with measurable outcomes, and fostering collaboration across business and technology se...

United StatesRemote

5 days ago

  •   8 - 10 years exp.  •   Finance & Insurance

$95K - $159K *

Unlock potential by joining a dynamic web engineering team to design, develop, and maintain scalable applications. Collaborate with cross-functional teams, mentor engineers, and enhance CI/CD practice...

United StatesRemote

Reposted 5 days ago

  •   5 - 7 years exp.  •   Healthcare

$75K - $90K *

Engage with strategic accounts to drive revenue growth through consultative sales and account management. Develop and maintain account plans, coordinate resources, and ensure customer satisfaction whi...

United StatesRemote

Reposted 5 days ago

  •   Less than 5 years exp.  •   Enterprise Technology

$118K - $178K *

Shape strategic initiatives by leading key deliverables and financial analyses. Collaborate with partners to enhance business processes and drive impactful recommendations, ensuring alignment and time...

United StatesRemote

5 days ago

  •   5 - 7 years exp.  •   Finance & Insurance

$125K - $150K *

Lead the charge in driving scalable revenue growth through integrated demand generation and digital marketing strategies. Collaborate with cross-functional teams to optimize marketing operations and e...

United StatesRemote

5 days ago

  •   8 - 10 years exp.  •   Healthcare

$174K - $250K *

Drive your career forward by partnering with executives to shape AI strategies, lead complex architecture discussions, and deliver tailored solutions that enhance enterprise AI ecosystems and revenue...

United StatesRemote

5 days ago

  •   5 - 7 years exp.  •   Enterprise Technology

$150K - $170K *

Take ownership of strategic finance leadership, optimizing cash flow and credit risk while developing innovative financing solutions to drive profitable growth and enhance operational efficiency acros...

United StatesRemote

5 days ago

  •   8 - 10 years exp.  •   Information Technology

$170K - $220K *

Lead the charge in technology strategy and execution, overseeing software engineering, business systems, and IT. Drive innovation and efficiency while ensuring robust architecture and team development...

United StatesRemote

5 days ago

  •   8 - 10 years exp.  •   Food & Beverages

$145K - $175K *

Transform customer success by managing DHS accounts through the entire lifecycle, ensuring seamless delivery, adoption, and growth of Skydio systems while collaborating with cross-functional teams to...

United StatesRemote

5 days ago

  •   5 - 7 years exp.  •   Consumer Technology

Frequently Asked Questions (FAQ)

  • What types of $100,000+ jobs can I find in Mississippi?question toggle

    Listings may include senior roles in healthcare, technology, manufacturing, finance, energy, engineering, and management. Opportunities change over time, so check current listings for available positions.

  • Which Mississippi cities have high-paying job opportunities?question toggle

    Professional opportunities may be listed in Jackson, Gulfport, Biloxi, Hattiesburg, Southaven, and other parts of the state, depending on employer hiring needs.

  • Are remote jobs available to Mississippi residents?question toggle

    Some employers offer remote or hybrid positions that may be open to Mississippi-based candidates. Review each listing to confirm location and work arrangement requirements.

  • How can I qualify for a $100,000+ job in Mississippi?question toggle

    Requirements vary by role. Employers commonly seek relevant experience, specialized skills, and a record of strong results; senior positions may also require leadership experience or advanced credentials.