Explore $100K+ Jobs in Michigan

Discover professional opportunities across Michigan with Ladders, where job seekers can explore vetted roles offering salaries of $100,000 or more. From established employers in Detroit to growing companies in Grand Rapids, Ann Arbor, Lansing, and other communities, Michigan offers career paths across a diverse range of industries and leadership levels.

Find Opportunities Across Michigan

Search jobs throughout the state, including major employment hubs such as Detroit, Grand Rapids, Ann Arbor, Lansing, and Kalamazoo. Depending on the role and employer, opportunities may offer on-site, hybrid, or remote work arrangements. Review each listing for location, compensation, responsibilities, and workplace expectations.

Explore Michigan Industries

Michigan is known for its automotive and advanced manufacturing industries, while also supporting opportunities in technology, healthcare, finance, engineering, supply chain, energy, and professional services. Employers seek experienced professionals for specialized individual-contributor roles as well as management and executive positions.

Build Your Next Career Move

Use Ladders to focus your search on vetted professional jobs paying $100,000 or more. Compare opportunities, identify roles that fit your experience, and tailor your résumé to highlight measurable results, leadership, and relevant expertise. Job availability and compensation vary by employer, location, and qualifications.

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1,000+

Jobs in Michigan

Average Salary in USD

Average Salary: $127,465

Sort By: Relevance

$145K - $215K *

Champion the promotion of innovative healthcare solutions by managing key accounts, driving sales, and educating healthcare professionals on disease management, while ensuring compliance and fostering...

3 days ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$155K - $210K *

Shape the future of regulatory policy by leading initiatives that influence key decisions and drive alignment across teams. Collaborate with stakeholders to advocate for impactful policies that suppor...

United StatesRemote

3 days ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$110K - $130K *

Champion innovative strategies to enhance patient access and treatment in rare diseases by collaborating with key stakeholders across health systems and specialty clinics, driving operational excellen...

3 days ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$193K - $262K *

Lead and optimize field effectiveness initiatives, driving sales performance through insights and operational excellence. Manage a high-performing team while collaborating cross-functionally to enhanc...

RemoteRemote

3 days ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$204K - $276K *

Lead the charge in global observational research, driving clinical operational strategy and execution. Collaborate with cross-functional teams to ensure quality and efficiency in evidence generation t...

RemoteRemote

3 days ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$145K - $215K *

Drive the future of healthcare by managing key accounts and promoting innovative therapies. Build strong relationships with healthcare professionals to achieve sales goals and enhance patient outcomes...

3 days ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$150K - $180K *

Champion strategic workforce planning and AI-driven work design to enhance capability, improve productivity, and advance internal mobility across teams. Drive tools and strategies aligning workforce p...

United StatesRemote

Reposted 3 days ago

  •   8 - 10 years exp.  •   Healthcare

$285K - $385K *

Lead regulatory due diligence for clinical/commercial assets, assessing risks and strategies for licensing, acquisitions, and partnerships. Collaborate across teams to ensure regulatory integration in...

RemoteRemote

3 days ago

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

$189K - $246K *

Lead clinical pharmacology strategies, integrating PK/PD assessments across development phases. Collaborate with cross-functional teams to guide decision-making and regulatory submissions, ensuring al...

RemoteRemote

3 days ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$145K - $220K *

Shape the future of Finance by managing AI transformation initiatives, collaborating with stakeholders to identify high-value use cases, and ensuring successful integration of AI solutions within Fina...

United StatesRemote

3 days ago

  •   11 - 15 years exp.  •   Information Technology

$80K - $95K *

Elevate your career by managing clinical sites and ensuring study quality, patient safety, and regulatory compliance. Collaborate with site teams to support enrollment and deliver impactful clinical r...

United StatesRemote

3 days ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$80K - $95K *

Engage in complex sales initiatives within the water industry, identifying high-value opportunities and developing strategies to enhance performance. Collaborate with teams to meet customer needs whil...

Livonia, MIRemote

3 days ago

  •   Less than 5 years exp.  •   Energy & Utilities

$121K - $170K *

Lead the transformation of storage solutions by leveraging deep technical expertise in NetApp Keystone and Storage-as-a-Service. Collaborate with customers to architect tailored solutions that optimiz...

United StatesRemote

3 days ago

  •   5 - 7 years exp.  •   Information Technology

$91K - $128K *

Join a team that's dedicated to empowering educators through impactful training sessions. You'll create engaging content and deliver customized Google for Education engagements, enhancing customer rel...

United StatesRemote

3 days ago

  •   5 - 7 years exp.  •   Information Technology

$90K - $145K *

Elevate critical power systems by designing, developing, and commissioning automation solutions. Collaborate with cross-functional teams to ensure project success while providing technical support and...

3 days ago

  •   Less than 5 years exp.  •   Manufacturing & Automotive

$100K - $145K *

Transform power system automation by designing, configuring, and supporting advanced protection systems. Collaborate with cross-functional teams to ensure quality project delivery and customer satisfa...

3 days ago

  •   Less than 5 years exp.  •   Manufacturing & Automotive

$64K - $96K *

Contribute to engineering projects by creating detailed designs, CAD drawings, and documentation. Collaborate with technical leads to deliver high-quality solutions on time and within budget, enhancin...

3 days ago

  •   Less than 5 years exp.  •   Manufacturing & Automotive

$136K - $181K *

Drive innovation by optimizing Clinical Operations through digital solutions, enhancing productivity across clinical trial phases while ensuring stakeholder collaboration and strategic alignment with...

United StatesRemote

Reposted 3 days ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$176K - $236K *

Lead the charge in global regulatory project management, driving oncology strategies and submissions across regions. Collaborate with cross-functional teams to ensure compliance and timely market acce...

United StatesRemote

3 days ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$114K - $154K *

Transform supply chain operations by managing SAP systems and processes, ensuring seamless logistics and distribution support. Drive efficiency and issue resolution across Commercial and Clinical Supp...

United StatesRemote

3 days ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$178K - $238K *

Drive impactful oncology drug development by leading program management, optimizing team efficiency, and ensuring strategic alignment across global projects to enhance patient outcomes and organizatio...

United StatesRemote

3 days ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$97K - $165K *

Shape the future of cloud solutions by leading technical relationships, validating AWS architectures, and driving presales strategies. Empower teams through mentorship while ensuring secure, scalable...

United StatesRemote

Reposted 3 days ago

  •   8 - 10 years exp.  •   Business Services

$121K - $206K *

Lead the charge in architecting and delivering Microsoft Azure and 365 solutions for SMBs. Oversee cloud migrations, security implementations, and project management while fostering strong partner rel...

United StatesRemote

Reposted 3 days ago

  •   8 - 10 years exp.  •   Business Services

$105K - $149K *

Drive security excellence by enhancing data protection and detection capabilities. Collaborate with cross-functional teams to implement DLP policies, automate processes, and ensure enterprise systems...

United StatesRemote

Reposted 3 days ago

  •   Less than 5 years exp.  •   Finance & Insurance

$80K - $95K *

Grow your career with a leadership role overseeing Command Center technical administration and reporting. Drive operational efficiency, manage teams, and enhance data quality to meet corporate objecti...

3 days ago

  •   5 - 7 years exp.  •   Healthcare

Frequently Asked Questions (FAQ)

  • What kinds of $100,000+ jobs can I find in Michigan?question toggle

    Listings may include senior and executive roles in fields such as engineering, technology, healthcare, finance, manufacturing, supply chain, and professional services. Available positions vary over time.

  • Which Michigan cities have professional job opportunities?question toggle

    Opportunities can be found in Detroit, Grand Rapids, Ann Arbor, Lansing, Kalamazoo, and other Michigan communities. Search by location to find roles that match your preferences.

  • Are Michigan jobs on Ladders vetted?question toggle

    Ladders focuses on vetted professional job opportunities with salaries of $100,000 or more. Check individual listings for details about the employer, role, location, and compensation.

  • Do Michigan jobs offer remote or hybrid work?question toggle

    Some employers may offer remote or hybrid arrangements, while others require on-site work. Review each job listing for its specific work-location expectations.