Explore $100K+ Jobs in Colorado

Discover vetted professional opportunities across Colorado with salaries of $100,000 or more. From established employers in Denver to growing companies in Boulder, Colorado Springs, and beyond, Ladders helps experienced professionals find roles that match their skills and career goals.

Find Opportunities Across Colorado

Colorado’s job market spans major metropolitan areas and communities throughout the state. Search for senior-level and executive openings in Denver, Boulder, Colorado Springs, Fort Collins, and other locations. Available opportunities vary by employer and industry, so explore current listings to see where your experience is in demand.

Explore Professional Roles and Industries

Colorado employers hire experienced professionals across fields such as technology, finance, healthcare, engineering, energy, operations, and sales. Browse listings by role, location, and other preferences to focus your search on positions suited to your background.

Make Your Colorado Job Search Count

Use Ladders to explore vetted jobs paying $100,000 or more. Refine your search by location and career interests, review role requirements, and apply to positions that align with your qualifications. Check back regularly for new opportunities across Colorado.

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$147K - $220K *

Drive strategic growth by managing key relationships within federal defense agencies, focusing on the Department of War. Lead complex sales cycles and ensure compliance while delivering innovative sol...

United StatesRemote

5 days ago

  •   8 - 10 years exp.  •   Healthcare

$73K - $92K *

Drive optimal patient care by assessing, planning, and coordinating comprehensive care plans. Focus on quality outcomes and cost-effective healthcare delivery across various medical specialties, ensur...

RemoteRemote

2 days ago

  •   Less than 5 years exp.  •   Finance & Insurance

$220K - $320K *

Champion new customer acquisition by leading the full enterprise sales cycle, building relationships with senior decision-makers, and delivering compelling business cases in highly regulated industrie...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Enterprise Technology

$222K - $393K *

Unlock your potential as a Senior Safety Physician, leading safety oversight for late-stage CNS clinical development. Collaborate with cross-functional teams to drive risk management and regulatory su...

United StatesRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$77K - $181K *

Transform underwriting technology by collaborating across teams to enhance systems, drive automation, and improve processes. Leverage your expertise to create actionable insights and ensure user profi...

United StatesRemote

Yesterday

  •   5 - 7 years exp.  •   Finance & Insurance

$230K - $280K *

Champion analytical development by leading strategy and execution for pipeline products. Drive compliance and quality control while building a high-performing team in a dynamic environment focused on...

United StatesRemote

1 week ago

  •   15+ years exp.  •   Information Technology

$174K - $217K *

Drive strategic leadership in industry partnerships and payor strategy, enhancing market access and competitive positioning. Lead a high-performing team to execute a multiyear plan that fosters sustai...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Healthcare

$198K - $298K *

Elevate your career by leading global investigator grants strategy and operations. Drive integration, governance, and financial controls while collaborating with cross-functional teams to ensure compl...

United StatesRemote

1 week ago

  •   15+ years exp.  •   Healthcare

$80K - $95K *

Unlock potential by providing expert legal analysis and guidance in Medicare hearings. Collaborate with a dedicated team to research statutes, draft decisions, and ensure fair outcomes for cases, whil...

2 days ago

  •   Less than 5 years exp.  •   Healthcare

$80K - $95K *

Elevate your legal career by conducting in-depth research and drafting decisions that shape Medicare hearings. Collaborate with a dedicated team to analyze complex cases and ensure fair outcomes for b...

2 days ago

  •   Less than 5 years exp.  •   Healthcare

$170K - $213K *

Lead the charge in shaping Brand Narrative by developing innovative concepts and collaborating closely with creative peers. Drive ambitious campaigns while building a dynamic team culture that fosters...

RemoteRemote

4 weeks ago

  •   Less than 5 years exp.  •   Finance & Insurance

$74K - $91K *

Join our team to investigate healthcare fraud, waste, and abuse through data analysis. Utilize your expertise in Excel and communication skills to analyze cases, conduct interviews, and support legal...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Healthcare

$180K - $195K *

Elevate healthcare marketing by transforming complex science into impactful strategies. Lead multidisciplinary teams to inspire creativity, drive behavior change, and build trusted client relationship...

RemoteRemote

Reposted 4 weeks ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$60K - $120K *

Unlock potential by ensuring quality in medical imaging data for clinical trials. Collaborate with a dynamic team to develop protocols and maintain compliance, using advanced imaging software across v...

Reposted 2 days ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$107K - $118K *

Join a team that's advancing biologics through analytical testing and method development. Collaborate cross-functionally to support process improvements and regulatory compliance while mentoring junio...

2 days ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$157K - $213K *

Elevate your career by developing strategic relationships and programs to enhance product value and clinical knowledge within the payer community, driving access and reimbursement strategies across na...

Today

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$184K - $249K *

Elevate brand engagement by leading integrated media strategies that connect consumer and healthcare professional teams, ensuring a cohesive approach to activation and media planning across diverse ch...

United StatesRemote

3 days ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$144K - $189K *

Unlock potential by leading product innovation in clinical genomics. Shape tools for case management and data workflows, ensuring efficiency and quality while collaborating with lab directors and engi...

United StatesRemote

4 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$85K - $125K *

Transform the future of protein analytics by leveraging your expertise in LC-MS and chromatographic techniques. Collaborate with a dynamic team to drive product development and regulatory submissions...

3 weeks ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$85K - $115K *

Advance analytical excellence at a leading biopharma firm by leveraging expertise in LC-MS and chromatographic techniques to support protein analytics from development to commercialization...

3 weeks ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$80K - $95K *

Lead the charge in managing site operations and vendor relations, ensuring compliance and efficiency in clinical research projects. Collaborate with teams to streamline processes and enhance training...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$110K - $130K *

Elevate your career by partnering with Medical Directors in clinical development. Drive scientific integrity and data quality for clinical trials through collaboration and expertise, ensuring protocol...

United StatesRemote

Reposted 4 days ago

  •   Less than 5 years exp.  •   Healthcare

$151K - $226K *

Lead the charge in managing observational research projects, ensuring operational excellence and cross-functional collaboration. Drive timely delivery of high-quality Real-World Evidence to support cl...

RemoteRemote

Reposted today

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$70K - $105K *

Manage and oversee multiple medical communications projects, ensuring timely delivery and operational excellence while collaborating with cross-functional teams and clients to drive impactful healthca...

United StatesRemote

Reposted 2 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$137K - $171K *

Engage healthcare providers as a scientific expert, delivering education and insights on oncology products. Collaborate with teams to support Medical Affairs initiatives while maintaining compliance a...

United StatesRemote

Reposted 2 days ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

Frequently Asked Questions (FAQ)

  • What kinds of $100K+ jobs can I find in Colorado?question toggle

    Listings may include senior and executive roles across fields such as technology, finance, healthcare, engineering, energy, operations, and sales. Available jobs and requirements vary by employer.

  • Where in Colorado can I search for professional jobs?question toggle

    Explore opportunities in Denver, Boulder, Colorado Springs, Fort Collins, and other Colorado communities. Use location filters to find jobs in your preferred area.

  • How can I find jobs in Colorado that pay $100,000 or more?question toggle

    Browse Colorado listings on Ladders and filter by location, role, and other preferences. Review each posting for compensation details and qualifications.

  • Are Colorado jobs on Ladders vetted?question toggle

    Ladders hosts vetted professional jobs paying $100,000 or more. Check individual listings for details about the employer, responsibilities, and requirements.