Find $100K+ Jobs in Massachusetts

Explore professional opportunities across Massachusetts with Ladders. Browse vetted jobs paying $100,000 or more, from roles in Boston and Cambridge to opportunities in Worcester, Springfield, and other communities throughout the state. Whether you’re pursuing your next leadership position or advancing your career in a specialized field, discover openings that match your experience and goals.

Explore Massachusetts Career Opportunities

Massachusetts is home to a diverse economy with employers in technology, healthcare, financial services, education, biotechnology, manufacturing, and professional services. Job availability and compensation vary by employer, role, and experience. Use Ladders to explore current openings and identify opportunities aligned with your skills.

Search by Location and Specialty

Focus your search on major employment centers such as Boston, Cambridge, and Worcester, or look across the state for roles that fit your preferences. Refine your search by job title, industry, seniority, and other relevant criteria to find opportunities suited to your career direction.

Advance Your Career with Ladders

Ladders specializes in vetted professional jobs paying $100,000 or more. Review listings, compare role requirements, and apply to positions that align with your qualifications. Set up a complete profile and keep your resume current to make it easier to pursue your next Massachusetts opportunity.

Remote
caret down
Compensation
caret down
Position Level
caret down
Time Posted
caret down
Industries
caret down
Locations
caret down
More
1
caret down
1,000+

Jobs in Massachusetts

Average Salary in USD

Average Salary: $125,897

Sort By: Relevance

$190K - $300K *

Transform medical affairs by driving scientific excellence and strategic initiatives in ophthalmology. Collaborate with cross-functional teams to enhance field readiness and optimize engagement across...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$142K - $224K *

Transform early clinical development by leading innovative trials and strategies. Collaborate with cross-functional teams to ensure compliance and excellence in execution, driving impactful results in...

1 week ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$173K - $272K *

Unlock potential by leading global regulatory strategies for immunology projects, ensuring compliance and optimizing product approvals. Collaborate with cross-functional teams and regulatory agencies...

RemoteRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$150K - $167K *

Lead transformative system planning initiatives by providing technical expertise, conducting complex studies, and ensuring compliance with industry standards. Collaborate across teams to enhance elect...

1 week ago

  •   8 - 10 years exp.  •   Energy & Utilities

$100K - $150K *

Unlock enterprise AI capabilities by designing and implementing AI agents and workflows. Collaborate across divisions to translate business needs into technical solutions, ensuring accuracy and reliab...

1 week ago

  •   Less than 5 years exp.  •   Finance & Insurance

$155K - $175K *

Champion the future of customer success by leading a team of Strategic GTM Success Managers. Drive strategic account planning, enhance customer experiences, and collaborate with Sales to maximize reve...

1 week ago

  •   5 - 7 years exp.  •   Information Technology

$163K - $186K *

Partner with us to drive excellence in external manufacturing, overseeing supplier relationships and ensuring high performance across cross-functional teams. Leverage your expertise in pharmaceutical...

1 week ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$105K - $129K *

Drive impactful market analysis and reporting as a Senior Analyst, leveraging data to guide strategic investments and growth opportunities. Collaborate with teams to enhance decision-making and optimi...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Legal & Accounting

$72K - $89K *

Join a team that's dedicated to delivering exceptional client service in fund administration. Manage investor portfolios, ensuring compliance and accuracy while fostering relationships and supporting...

1 week ago

  •   Less than 5 years exp.  •   Finance & Insurance

$81K *

Manage and enhance public health technology platforms, ensuring secure, reliable operations for local, state, and federal agencies. Collaborate with cross-functional teams to optimize system performan...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Enterprise Technology

$135K - $160K *

Empower the go-to-market organization by architecting and optimizing revenue operations, driving AI innovation, and enhancing team productivity through strategic systems thinking and advanced automati...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Information Technology

$110K - $130K *

Lead the enhancement of security measures for cloud-based healthcare solutions, focusing on vulnerability management, incident response, and compliance. Collaborate with cross-functional teams to ensu...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Healthcare

$100K - $125K *

Join our dynamic finance team as you drive margin and profitability through detailed analysis and strategic insights. Collaborate with senior leadership to transform data into actionable initiatives t...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Healthcare

$122K - $179K *

Advance your career by leading enterprise analytics and data governance initiatives. Collaborate with executive leadership to create analytics solutions that drive strategic decision-making and enhanc...

United StatesRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Healthcare

$170K - $300K *

Transform federal income tax consulting by leveraging your expertise in M&A structuring, accounting methods, and partnership issues. Collaborate with a dynamic team to deliver innovative solutions and...

1 week ago

  •   15+ years exp.  •   Legal & Accounting

$64K - $165K *

Join a team that's shaping the future of autonomous systems through innovative mechanical engineering. Contribute to the design, development, and integration of advanced underwater vehicles and system...

Reposted 1 week ago

  •   Less than 5 years exp.  •   Manufacturing & Automotive

$160K - $180K *

Empower commercial operations by leading a dynamic Deal Desk team, driving strategy, optimizing processes, and executing complex transactions in a fast-paced SaaS environment. Collaborate cross-functi...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Enterprise Technology

$75K - $95K *

Shape the security landscape for a professional sports team by providing comprehensive protection for players and staff during events, travel, and training. Collaborate with leadership to enhance secu...

1 week ago

  •   Less than 5 years exp.  •   Hospitality & Recreation

$178K - $307K *

Transform global procurement strategy and digital capabilities by leading enterprise-wide initiatives that optimize processes, drive value creation, and enhance user experience across the Source-to-Pa...

Reposted 1 week ago

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

$100K - $120K *

Deliver innovative mineral processing solutions to enhance plant operations, optimize costs, and improve product quality. Collaborate with cross-functional teams to drive project success and ensure co...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$95K - $115K *

Drive security excellence as a key advisor on information systems security, overseeing policies and risk management for Special Access Programs. Collaborate with DoD agencies to ensure robust protecti...

1 week ago

  •   5 - 7 years exp.  •   Aerospace & Defense

$95K - $115K *

Lead the development and implementation of information system security policies, ensuring compliance with DoD standards. Collaborate with teams to assess risks and enhance security measures for Specia...

1 week ago

  •   5 - 7 years exp.  •   Aerospace & Defense

$175K - $210K *

Transform infrastructure engineering by leading a global team to develop and implement design standards for AI factories, ensuring consistency and efficiency across projects while driving innovation a...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Enterprise Technology

$187K - $205K *

Partner with us to enhance network infrastructure by providing senior-level support for Private 5G and communications systems, ensuring secure and efficient delivery of voice, data, and video services...

Reposted 1 week ago

  •   11 - 15 years exp.  •   Technical Services

$84K - $112K *

Lead the charge in optimizing network capacity and implementing innovative solutions. Collaborate across teams to ensure best-in-class service delivery while managing projects and driving strategic in...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Telecommunications & Hardware

Frequently Asked Questions (FAQ)

  • What types of $100,000+ jobs can I find in Massachusetts?question toggle

    Listings may include professional and leadership roles across fields such as technology, healthcare, finance, biotechnology, education, manufacturing, and business services. Available positions change, so browse current listings for the latest opportunities.

  • Where can I find professional jobs in Massachusetts?question toggle

    Search across the state, including major employment centers such as Boston, Cambridge, and Worcester. You can also use location filters to explore roles in other Massachusetts communities.

  • Are the Massachusetts jobs on Ladders vetted?question toggle

    Ladders features vetted professional job listings paying $100,000 or more. Review each listing for details about the employer, responsibilities, qualifications, and compensation.

  • How can I find a Massachusetts job that matches my experience?question toggle

    Use filters such as location, job title, industry, and seniority to narrow your search. Keep your resume current and compare each listing’s requirements with your skills and career goals.