Find $100K+ Jobs in Massachusetts

Explore professional opportunities across Massachusetts with Ladders. Browse vetted jobs paying $100,000 or more, from roles in Boston and Cambridge to opportunities in Worcester, Springfield, and other communities throughout the state. Whether you’re pursuing your next leadership position or advancing your career in a specialized field, discover openings that match your experience and goals.

Explore Massachusetts Career Opportunities

Massachusetts is home to a diverse economy with employers in technology, healthcare, financial services, education, biotechnology, manufacturing, and professional services. Job availability and compensation vary by employer, role, and experience. Use Ladders to explore current openings and identify opportunities aligned with your skills.

Search by Location and Specialty

Focus your search on major employment centers such as Boston, Cambridge, and Worcester, or look across the state for roles that fit your preferences. Refine your search by job title, industry, seniority, and other relevant criteria to find opportunities suited to your career direction.

Advance Your Career with Ladders

Ladders specializes in vetted professional jobs paying $100,000 or more. Review listings, compare role requirements, and apply to positions that align with your qualifications. Set up a complete profile and keep your resume current to make it easier to pursue your next Massachusetts opportunity.

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1,000+

Jobs in Massachusetts

Average Salary in USD

Average Salary: $125,890

Sort By: Relevance

$117K - $189K *

Pioneer global Orexin development programs by driving project management efforts. Partner with the Global Team Leader to oversee cross-functional teams, manage critical activities, and ensure project...

RemoteRemote

Reposted 3 days ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$141K - $206K *

Unlock potential by leading biophysical characterization of lipid nanoparticle formulations. Collaborate with cross-functional teams to enhance product quality and safety, driving innovation in RNA-LN...

3 days ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$160K - $200K *

Unlock your potential by collaborating with our CEO to tackle high-impact challenges. Gain hands-on experience across functions in a rapidly growing company, preparing you for future leadership roles...

3 days ago

  •   Less than 5 years exp.  •   Finance & Insurance

$75K - $95K *

Unlock potential by managing Genesys Cloud configurations and ensuring system integrity. Collaborate with teams to implement changes, troubleshoot issues, and maintain documentation for optimal contac...

United StatesRemote

3 days ago

  •   Less than 5 years exp.  •   Transportation

$143K - $194K *

Lead the charge in enhancing AI-driven software solutions, optimizing performance, and expanding integrations. Own features end-to-end, ensuring reliability and scalability while mentoring peers and i...

3 days ago

  •   Less than 5 years exp.  •   Retail & Consumer Goods

$76K - $98K *

Contribute to the quality assurance of medical devices by processing complaint samples, conducting mechanical tests, and collaborating with engineers to ensure compliance with industry standards. Join...

3 days ago

  •   Less than 5 years exp.  •   Healthcare

$166K - $189K *

Unlock potential by leading externally sponsored research programs in hematology/oncology. Oversee governance, manage budgets, and ensure compliance while collaborating with cross-functional teams to...

3 days ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$175K *

Conduct in-depth research and analysis of REITs, develop investment insights, and generate stock recommendations to support portfolio management and investment strategies...

3 days ago

  •   5 - 7 years exp.  •   Finance & Insurance

$240K - $290K *

Elevate your career by leading a dynamic engineering team focused on production and infrastructure. Drive performance, foster collaboration, and deliver innovative solutions while managing diverse tec...

United StatesRemote

3 days ago

  •   8 - 10 years exp.  •   Enterprise Technology

$154K - $242K *

Champion operational excellence by leading global tax provisions and compliance. Collaborate with cross-functional teams to enhance processes, mentor talent, and drive strategic tax initiatives while...

United StatesRemote

3 days ago

  •   8 - 10 years exp.  •   Information Technology

$82K - $150K *

Accelerate growth by driving new customer acquisition and expanding market share within the dental implant community. Leverage a hunter mentality to convert competitive accounts and position value-ori...

United StatesRemote

Reposted 3 days ago

  •   Less than 5 years exp.  •   Healthcare

$108K - $148K *

Execute thorough testing strategies to enhance software quality, ensuring robust performance and reliable functionality through detailed documentation and collaboration with engineering teams...

Reposted 3 days ago

  •   Less than 5 years exp.  •   Manufacturing & Automotive

$145K - $220K *

Join a team that leverages AI/ML to strengthen U.S. cyber operations. Collaborate on innovative solutions, enhance cyber resilience, and contribute to a culture of growth and learning in a fast-paced...

Reposted 3 days ago

  •   5 - 7 years exp.  •   Education, Government & Non-Profit

$85K *

Design dynamic motion graphics and animations for various digital platforms. Collaborate with the creative team to produce engaging content that enhances branding and marketing efforts, while staying...

3 days ago

  •   Less than 5 years exp.  •   Food & Beverages

$130K - $160K *

Transform data operations by leading our Snowflake platform migration, ensuring security, reliability, and cost efficiency while collaborating across teams to standardize practices and enhance data ma...

United StatesRemote

3 days ago

  •   5 - 7 years exp.  •   Legal & Accounting

$75K - $90K *

Lead the charge in expanding our MTSS product roadmap, guiding development and commercialization efforts. Collaborate with educators and cross-functional teams to enhance assessment tools that support...

United StatesRemote

Reposted 3 days ago

  •   Less than 5 years exp.  •   Education, Government & Non-Profit

$107K - $216K *

Transform data onboarding for quantitative research by collaborating with tech partners to integrate and maintain high-quality financial datasets, ensuring they meet rigorous standards for usability a...

3 days ago

  •   5 - 7 years exp.  •   Finance & Insurance

$125K - $157K *

Join our dynamic team to design and enhance a web portal application, improving user experience and functionality. Collaborate with engineers and product managers to deliver impactful solutions that s...

United StatesRemote

3 days ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$110K - $130K *

Elevate patient care by providing expert pharmacy consulting and clinical services. Manage pharmacy operations, enhance workflow efficiency, and develop staff while ensuring compliance with regulation...

3 days ago

  •   Less than 5 years exp.  •   Retail & Consumer Goods

$110K - $130K *

Champion pharmacy excellence by delivering empathetic patient care, managing pharmacy operations, and enhancing team performance. Drive strategic initiatives to improve patient outcomes and ensure com...

3 days ago

  •   Less than 5 years exp.  •   Retail & Consumer Goods

$110K - $130K *

Elevate patient care by providing expert pharmacy consulting and clinical services. Manage pharmacy operations, enhance patient experiences, and lead staff development while ensuring compliance with r...

3 days ago

  •   Less than 5 years exp.  •   Retail & Consumer Goods

$110K - $130K *

Shape patient care by providing expert pharmacy consulting and clinical services. Lead a team to enhance patient experiences, manage pharmacy operations, and ensure compliance with regulations while f...

3 days ago

  •   Less than 5 years exp.  •   Retail & Consumer Goods

$130K - $150K *

Optimize IT operations by managing systems, enhancing security, and leading projects. Ensure seamless network infrastructure and provide technical support while coordinating with vendors and maintaini...

United StatesRemote

3 days ago

  •   5 - 7 years exp.  •   Information Technology

$146K - $263K *

Innovate by leading the design and implementation of scalable AI inference systems. Collaborate across teams to optimize performance and mentor engineers, ensuring high-quality solutions in a globally...

3 days ago

  •   8 - 10 years exp.  •   Information Technology

$100K - $120K *

Elevate your career as a Senior Philanthropic Advisor, driving major gifts and building lasting donor relationships. Collaborate with leadership to secure transformational commitments that enhance com...

3 days ago

  •   5 - 7 years exp.  •   Education, Government & Non-Profit

Frequently Asked Questions (FAQ)

  • What types of $100,000+ jobs can I find in Massachusetts?question toggle

    Listings may include professional and leadership roles across fields such as technology, healthcare, finance, biotechnology, education, manufacturing, and business services. Available positions change, so browse current listings for the latest opportunities.

  • Where can I find professional jobs in Massachusetts?question toggle

    Search across the state, including major employment centers such as Boston, Cambridge, and Worcester. You can also use location filters to explore roles in other Massachusetts communities.

  • Are the Massachusetts jobs on Ladders vetted?question toggle

    Ladders features vetted professional job listings paying $100,000 or more. Review each listing for details about the employer, responsibilities, qualifications, and compensation.

  • How can I find a Massachusetts job that matches my experience?question toggle

    Use filters such as location, job title, industry, and seniority to narrow your search. Keep your resume current and compare each listing’s requirements with your skills and career goals.