Explore $100K+ Jobs in Massachusetts

Find professional opportunities in Massachusetts with salaries of $100,000 or more. From Boston and Cambridge to Worcester, Springfield, and other communities, the state offers a varied job market for experienced professionals seeking their next career move. Browse vetted listings on Ladders and explore roles aligned with your skills, experience, and compensation goals.

Discover Opportunities Across Massachusetts

Massachusetts is home to employers in industries including biotechnology, healthcare, finance, technology, higher education, consulting, and advanced manufacturing. Opportunities can range from specialized individual-contributor positions to director, vice president, and executive roles. Availability varies by employer and location, so review each listing for its requirements and work arrangement.

Find Roles That Match Your Experience

Use Ladders to explore high-paying professional jobs and focus your search by title, location, and area of expertise. Review responsibilities and qualifications carefully, then tailor your résumé to highlight relevant achievements, leadership experience, and measurable results.

Build Your Massachusetts Job Search

Whether you are targeting a role in Greater Boston or considering opportunities elsewhere in the state, a focused search can help you identify positions that fit your career priorities. Explore Massachusetts listings on Ladders to take the next step toward a role paying $100,000 or more.

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1,000+

Jobs in Massachusetts

Average Salary in USD

Average Salary: $125,890

Sort By: Relevance

$167K - $190K *

Lead impactful genomic studies in Oncology, interpreting NGS data to drive biological insights and propose novel experiments. Collaborate with cross-functional teams to develop innovative drug strateg...

Reposted 3 days ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$175K - $200K *

Drive strategic medical initiatives in Rare Neurology, collaborating with cross-functional teams to enhance patient outcomes. Leverage your expertise to shape launch strategies and foster relationship...

RemoteRemote

Reposted 3 days ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$150K - $170K *

Join us to lead regulatory review of promotional materials, ensuring compliance with FDA regulations. Collaborate with cross-functional teams to enhance product messaging and contribute to the success...

Reposted 3 days ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$160K - $200K *

Empower your career by bridging clients and the equity market through precise execution and strategic relationship building. Innovate and drive revenue growth while ensuring compliance and operational...

Reposted 3 days ago

  •   Less than 5 years exp.  •   Finance & Insurance

$175K - $210K *

Lead the global SIOP process, ensuring synchronization across Sales, Marketing, and Supply Chain functions to optimize inventory and enhance operational efficiency for $1.2B in annual sales. Drive str...

RemoteRemote

Reposted 3 days ago

  •   11 - 15 years exp.  •   Manufacturing & Automotive

$200K - $257K *

Unlock potential by providing compassionate psychiatric care in a hybrid setting. Collaborate with a dedicated team to enhance patient outcomes while enjoying flexible scheduling and a supportive work...

3 days ago

  •   Less than 5 years exp.  •   Healthcare

$86K - $95K *

Transform your career by joining a dynamic team focused on quality control. Contribute to testing and analysis in a cGMP environment, ensuring compliance and excellence in pharmaceutical products. You...

Reposted 3 days ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$160K - $190K *

Join our dynamic legal team to support commercial operations and transactions. You'll manage contracts, advise on compliance, and enhance processes in a fast-paced environment, driving legal support a...

Reposted 3 days ago

  •   8 - 10 years exp.  •   Energy & Utilities

$110K - $130K *

Champion our employer brand initiatives by leading integrated marketing campaigns, optimizing recruitment strategies, and enhancing candidate engagement to position us as a top choice for talent in th...

Reposted 3 days ago

  •   5 - 7 years exp.  •   Energy & Utilities

$140K - $175K *

Shape technical innovation by leading cross-team efforts in system architecture and development. Drive scalable improvements, mentor peers, and influence business outcomes while ensuring long-term mai...

United StatesRemote

3 days ago

  •   5 - 7 years exp.  •   Information Technology

$110K - $130K *

Optimize product costs and drive cost engineering processes for electromechanical systems. Collaborate with finance and engineering teams to establish best practices and support data-driven decisions...

Reposted 3 days ago

  •   5 - 7 years exp.  •   Energy & Utilities

$300K - $500K *

Champion innovation by architecting and developing high-performance, real-time trading web apps. Leverage your expertise to enhance user experience and drive product evolution in a dynamic, collaborat...

United StatesRemote

3 days ago

  •   5 - 7 years exp.  •   Finance & Insurance

$64K - $102K *

Elevate network performance by deploying and optimizing voice solutions, ensuring 99.999% uptime. Collaborate on network planning and security, while providing expert support and documentation for com...

RemoteRemote

Reposted 3 days ago

  •   8 - 10 years exp.  •   Technical Services

$80K - $95K *

Elevate your nursing career by leading a dedicated team, delivering exceptional resident care, and implementing personalized care plans in a collaborative, supportive environment committed to quality...

Reposted 3 days ago

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$180K - $207K *

Optimize the request-to-quote experience for key customers by redesigning workflows, integrating AI agents, and enhancing operational efficiency. Collaborate across teams to drive product strategy and...

3 days ago

  •   8 - 10 years exp.  •   Manufacturing & Automotive

$60K - $120K *

Empower growth by engaging existing customers, identifying upgrade opportunities, and managing the full sales cycle. Build trust with small business owners while driving revenue through effective outr...

United StatesRemote

3 days ago

  •   Less than 5 years exp.  •   Information Technology

$155K - $228K *

Join a team that's shaping the future of identity products, delivering secure, developer-first experiences. Collaborate with leadership to build innovative solutions that empower customers and enhance...

United StatesRemote

3 days ago

  •   5 - 7 years exp.  •   Transportation

$140K - $220K *

Join a dynamic team focused on driving new business growth through strategic sales initiatives. Engage with key decision-makers, execute impactful presentations, and leverage multi-channel outreach to...

United StatesRemote

3 days ago

  •   Less than 5 years exp.  •   Information Technology

$120K - $145K *

Transform the clinical sales landscape by promoting MCS products, driving revenue, and providing essential training and support to medical professionals while ensuring exceptional customer experiences...

Reposted 3 days ago

  •   Less than 5 years exp.  •   Healthcare

$211K - $290K *

Champion global regulatory strategies to drive product approvals and market access for innovative dental solutions. Collaborate with cross-functional teams to navigate complex regulatory landscapes an...

RemoteRemote

3 days ago

  •   8 - 10 years exp.  •   Healthcare

$87K - $109K *

Optimize global regulatory activities for medical devices, ensuring compliance in labeling, UDI, and product data. Collaborate with cross-functional teams to support product registrations and maintain...

Massachusetts, USRemote

Reposted 3 days ago

  •   Less than 5 years exp.  •   Healthcare

$125K - $150K *

Drive innovation in medical device sales by leading regional growth initiatives, expanding partnerships, and enhancing market presence while directly connecting with healthcare professionals in the NW...

Reposted 3 days ago

  •   Less than 5 years exp.  •   Healthcare

$121K - $194K *

Join a dynamic team as you design electro-mechanical solutions for advanced aerospace and defense applications, collaborating across functions to translate customer needs into manufacturable designs a...

Reposted 3 days ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$85K - $144K *

Take ownership of the North America affiliate channel by driving strategy, measuring performance, and fostering growth while leading a team and optimizing partnerships for maximum profitability...

United StatesRemote

Reposted 3 days ago

  •   5 - 7 years exp.  •   Business Services

$130K - $155K *

Drive operational excellence by managing TechOps and enhancing IT infrastructure. Collaborate with DevOps and SecOps to ensure high availability and security of applications while mentoring a high-per...

3 days ago

  •   5 - 7 years exp.  •   Information Technology

Frequently Asked Questions (FAQ)

  • What types of $100,000+ jobs can I find in Massachusetts?question toggle

    Listings may include experienced professional, management, director, vice president, and executive roles across fields such as technology, healthcare, biotechnology, finance, education, and manufacturing. Specific openings and requirements vary.

  • Where in Massachusetts can I find high-paying jobs?question toggle

    Opportunities may be available in Boston, Cambridge, Worcester, Springfield, and other parts of the state. Browse current listings and check each posting for its location and work arrangement.

  • How can I search for Massachusetts jobs paying $100,000 or more?question toggle

    Browse Massachusetts listings on Ladders and refine your search by job title, location, and expertise. Review each posting's compensation information and qualifications.

  • Are Massachusetts jobs on Ladders vetted?question toggle

    Ladders hosts vetted professional job listings. Check the details of each listing to learn about the employer, role, location, compensation, and application requirements.