Explore $100K+ Jobs in Massachusetts

Find professional opportunities in Massachusetts with salaries of $100,000 or more. From Boston and Cambridge to Worcester, Springfield, and other communities, the state offers a varied job market for experienced professionals seeking their next career move. Browse vetted listings on Ladders and explore roles aligned with your skills, experience, and compensation goals.

Discover Opportunities Across Massachusetts

Massachusetts is home to employers in industries including biotechnology, healthcare, finance, technology, higher education, consulting, and advanced manufacturing. Opportunities can range from specialized individual-contributor positions to director, vice president, and executive roles. Availability varies by employer and location, so review each listing for its requirements and work arrangement.

Find Roles That Match Your Experience

Use Ladders to explore high-paying professional jobs and focus your search by title, location, and area of expertise. Review responsibilities and qualifications carefully, then tailor your résumé to highlight relevant achievements, leadership experience, and measurable results.

Build Your Massachusetts Job Search

Whether you are targeting a role in Greater Boston or considering opportunities elsewhere in the state, a focused search can help you identify positions that fit your career priorities. Explore Massachusetts listings on Ladders to take the next step toward a role paying $100,000 or more.

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1,000+

Jobs in Massachusetts

Average Salary in USD

Average Salary: $126,012

Sort By: Relevance

$144K - $230K *

Engage with our sales team as a Technical Sales Lead, driving technology evaluations and managing customer relationships. Leverage your expertise in telecommunications to ensure satisfaction throughou...

United StatesRemote

3 days ago

  •   8 - 10 years exp.  •   Telecommunications & Hardware

$150K - $180K *

Lead the charge in developing and executing cash management strategies to drive new sales, enhance client relationships, and mentor a high-performing team, ensuring exceptional service for complex com...

3 days ago

  •   5 - 7 years exp.  •   Finance & Insurance

$110K - $159K *

Empower the Clinical Documentation Integrity team by ensuring staff competency through quality assurance, training, and performance management. Collaborate on action plans and foster associate develop...

United StatesRemote

3 days ago

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$124K - $158K *

Lead the charge in transforming patient care by overseeing pharmacy operations, ensuring safe dispensing, and fostering a culture of excellence while supporting team development and compliance with re...

3 days ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$225K - $418K *

Champion advanced analytics to enhance patient outcomes through data-driven insights. Lead a team in analyzing healthcare data, fostering strategic partnerships, and communicating complex findings to...

United StatesRemote

3 days ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$90K - $199K *

Shape the future of healthcare strategy by leading high-impact initiatives, collaborating with stakeholders, and delivering insightful analysis to drive growth and improve care delivery across diverse...

3 days ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$152K - $283K *

Accelerate analytics governance and operations by leading initiatives that enhance decision-making processes, streamline reporting, and modernize workflows across teams, ensuring effective collaborati...

United StatesRemote

3 days ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$213K - $259K *

Drive strategic direction and oversee complex CMC projects, ensuring regulatory compliance and effective stakeholder engagement. Lead cross-functional teams and represent the organization in health au...

3 days ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$137K - $215K *

Elevate patient care by leading lifecycle management of combination products, ensuring technical excellence in device engineering and compliance, while collaborating across functions to enhance drug d...

Reposted 3 days ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$151K - $237K *

Elevate patient outcomes by managing relationships with KOLs and HCPs, analyzing scientific data, and executing medical strategies. This role requires advanced knowledge in therapeutic areas and a com...

Massachusetts, USRemote

3 days ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$123K - $168K *

Engage with healthcare professionals to drive product growth and acceptance. Build lasting relationships, educate stakeholders, and collaborate cross-functionally to enhance market presence and uphold...

United StatesRemote

3 days ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$155K - $258K *

Shape the future of AI in healthcare by leading architectural design and technical strategy for LLM-powered systems. Mentor engineers, ensure compliance, and drive innovation in a highly regulated env...

United StatesRemote

3 days ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$105K - $120K *

Drive the substantiation of health claims for dietary supplements by reviewing scientific evidence and collaborating with cross-functional teams to ensure compliance with regulatory standards and enha...

United StatesRemote

3 days ago

  •   Less than 5 years exp.  •   Technical Services

$110K - $207K *

Shape the future of enterprise data management by leading product strategy and delivery for innovative cloud-native data services that empower investment firms to master and distribute their data effe...

3 days ago

  •   8 - 10 years exp.  •   Finance & Insurance

$70K - $130K *

Empower your career by leading client conversion initiatives in Back Office Accounting and Custody. Drive project management, enhance client relationships, and implement operational changes while ensu...

3 days ago

  •   5 - 7 years exp.  •   Finance & Insurance

$156K - $281K *

Drive innovative solutions by leading complex Federal acquisitions, guiding cross-functional teams, and delivering high-quality proposals. Leverage technical expertise to elevate win probability and e...

United StatesRemote

3 days ago

  •   11 - 15 years exp.  •   Information Technology

$118K - $224K *

Drive the development and governance of complex Integrated Master Schedules, ensuring alignment with technical scope and contractual requirements while performing advanced schedule analysis and provid...

3 days ago

  •   8 - 10 years exp.  •   Aerospace & Defense

$118K - $224K *

Drive the development and governance of complex Integrated Master Schedules, ensuring alignment with technical and contractual requirements while performing advanced schedule analysis to support progr...

3 days ago

  •   8 - 10 years exp.  •   Aerospace & Defense

$118K - $224K *

Shape the future of program management by developing and analyzing complex Integrated Master Schedules. Collaborate across teams to ensure project alignment with technical and contractual requirements...

3 days ago

  •   8 - 10 years exp.  •   Aerospace & Defense

$175K *

Advance innovative research and product development in investment strategies, leveraging quantitative skills to transform academic findings into actionable tools, while collaborating with industry lea...

Reposted 3 days ago

  •   Less than 5 years exp.  •   Finance & Insurance

$77K - $108K *

Drive the implementation and support of AI workload orchestration platforms, ensuring high-quality technical outcomes in client environments. Collaborate across teams to deliver reliable, secure acces...

United StatesRemote

3 days ago

  •   Less than 5 years exp.  •   Information Technology

$86K - $165K *

Join a dynamic Systems Engineering team to modernize Air Traffic Control RADAR systems, driving innovation and ensuring safety through rigorous requirement verification and creative solutions for comp...

3 days ago

  •   Less than 5 years exp.  •   Aerospace & Defense

$221K - $271K *

Lead the charge in transforming Collections & Recovery capabilities through innovative product strategies, leveraging AI and advanced analytics to enhance customer engagement and operational efficienc...

3 days ago

  •   8 - 10 years exp.  •   Finance & Insurance

$65K - $100K *

Join a team that's dedicated to enhancing customer experiences and driving store performance. Lead and develop associates while implementing business solutions and fostering a culture of continuous im...

3 days ago

  •   Less than 5 years exp.  •   Retail & Consumer Goods

$110K - $130K *

Join a team that empowers pharmaceutical and healthcare clients to transform customer experiences through innovative marketing technology and data-driven strategies, guiding initiatives that enhance e...

Reposted 3 days ago

  •   5 - 7 years exp.  •   Business Services

Frequently Asked Questions (FAQ)

  • What types of $100,000+ jobs can I find in Massachusetts?question toggle

    Listings may include experienced professional, management, director, vice president, and executive roles across fields such as technology, healthcare, biotechnology, finance, education, and manufacturing. Specific openings and requirements vary.

  • Where in Massachusetts can I find high-paying jobs?question toggle

    Opportunities may be available in Boston, Cambridge, Worcester, Springfield, and other parts of the state. Browse current listings and check each posting for its location and work arrangement.

  • How can I search for Massachusetts jobs paying $100,000 or more?question toggle

    Browse Massachusetts listings on Ladders and refine your search by job title, location, and expertise. Review each posting's compensation information and qualifications.

  • Are Massachusetts jobs on Ladders vetted?question toggle

    Ladders hosts vetted professional job listings. Check the details of each listing to learn about the employer, role, location, compensation, and application requirements.