Explore $100K+ Jobs in Massachusetts

Find professional opportunities in Massachusetts with salaries of $100,000 or more. From Boston and Cambridge to Worcester, Springfield, and other communities, the state offers a varied job market for experienced professionals seeking their next career move. Browse vetted listings on Ladders and explore roles aligned with your skills, experience, and compensation goals.

Discover Opportunities Across Massachusetts

Massachusetts is home to employers in industries including biotechnology, healthcare, finance, technology, higher education, consulting, and advanced manufacturing. Opportunities can range from specialized individual-contributor positions to director, vice president, and executive roles. Availability varies by employer and location, so review each listing for its requirements and work arrangement.

Find Roles That Match Your Experience

Use Ladders to explore high-paying professional jobs and focus your search by title, location, and area of expertise. Review responsibilities and qualifications carefully, then tailor your résumé to highlight relevant achievements, leadership experience, and measurable results.

Build Your Massachusetts Job Search

Whether you are targeting a role in Greater Boston or considering opportunities elsewhere in the state, a focused search can help you identify positions that fit your career priorities. Explore Massachusetts listings on Ladders to take the next step toward a role paying $100,000 or more.

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1,000+

Jobs in Massachusetts

Average Salary in USD

Average Salary: $125,888

Sort By: Relevance

$92K - $160K *

Join a team that's driving innovation in EdTech by leading strategic ISV sales. You'll collaborate with cross-functional teams to enhance AWS adoption, achieve growth targets, and build lasting relati...

3 days ago

  •   Less than 5 years exp.  •   Retail & Consumer Goods

$175K - $210K *

Lead the development and execution of international regulatory strategies, ensuring alignment with corporate objectives and global requirements. Collaborate with cross-functional teams to guide critic...

3 days ago

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

$82K - $123K *

Drive innovative software solutions by integrating AI capabilities and enhancing user experiences. Collaborate with teams to develop, test, and implement applications, ensuring quality and efficiency...

United StatesRemote

3 days ago

  •   Less than 5 years exp.  •   Information Technology

$88K - $105K *

Contribute to organizational success by partnering with leaders to enhance HR practices, drive employee engagement, and support growth initiatives, ensuring a positive experience throughout the employ...

United StatesRemote

3 days ago

  •   5 - 7 years exp.  •   Transportation

$85K - $100K *

Transform healthcare delivery by supporting the launch and adoption of innovative RFA technologies. Collaborate with clinical teams to ensure safe, effective implementation, providing essential traini...

3 days ago

  •   5 - 7 years exp.  •   Healthcare

$93K - $129K *

Manage clinical excellence and elevate resident health by leading nursing teams, ensuring compliance, and driving quality initiatives. Collaborate with physicians and oversee care programs to deliver...

3 days ago

  •   Less than 5 years exp.  •   Healthcare

$184K - $266K *

Lead the end-to-end management of complex enterprise PLM implementations, driving alignment across engineering, operations, and IT to ensure successful delivery and measurable business outcomes in a d...

3 days ago

  •   8 - 10 years exp.  •   Manufacturing & Automotive

$95K - $115K *

Champion project success by managing SAP OTC enhancement initiatives, ensuring effective planning, stakeholder engagement, and delivery across Agile and Waterfall methodologies while driving continuou...

RemoteRemote

3 days ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$120K - $135K *

Shape the future of personalized marketing by leading strategy and execution across digital channels. Collaborate with teams to define impactful customer journeys and optimize campaigns for measurable...

RemoteRemote

3 days ago

  •   5 - 7 years exp.  •   Healthcare

$95K - $115K *

Elevate your career by designing and supporting Oracle PeopleSoft EDI integrations. Collaborate with teams to enhance application logic and ensure seamless order-to-cash processes across global partne...

3 days ago

  •   Less than 5 years exp.  •   Staffing

$165K - $175K *

Champion product strategy and lifecycle management, translating customer needs into market-driven solutions. Collaborate with cross-functional teams to drive product success in the rapidly evolving li...

Reposted 3 days ago

  •   8 - 10 years exp.  •   Healthcare

$83K - $222K *

Empower innovation by delivering high-quality web applications and APIs. Collaborate with cross-functional teams to create intuitive data visualizations and integrate AI capabilities, enhancing Payer...

RemoteRemote

3 days ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$85K - $95K *

Unlock potential by leading the development and optimization of manufacturing processes for innovative medical technologies, ensuring efficiency, safety, and quality in production while collaborating...

3 days ago

  •   Less than 5 years exp.  •   Healthcare

$120K - $145K *

Transform healthcare data solutions by designing scalable architectures, optimizing data pipelines, and ensuring compliance with regulations. Collaborate with cross-functional teams to deliver high-qu...

United StatesRemote

Reposted 3 days ago

  •   8 - 10 years exp.  •   Healthcare

$120K - $187K *

Unlock potential by designing and optimizing enterprise-scale data solutions. Collaborate across functions to enhance analytics and decision-making, leveraging Databricks and Azure services for high-p...

3 days ago

  •   5 - 7 years exp.  •   Food & Beverages

$185K - $344K *

Advance enterprise patient intelligence by leading strategy, governance, and analytics. Collaborate across functions to enhance decision-making and drive insights that improve patient outcomes and bus...

United StatesRemote

3 days ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$160K - $190K *

Take ownership of financial strategy and operations, leading a dynamic finance team to enhance performance, ensure compliance, and drive growth in a collaborative, employee-owned environment...

United StatesRemote

3 days ago

  •   8 - 10 years exp.  •   Transportation

$181K - $291K *

Lead the charge in managing the full systems development lifecycle for enterprise applications, ensuring data quality and integrity while evolving best practices across healthcare operations and suppo...

RemoteRemote

3 days ago

  •   11 - 15 years exp.  •   Healthcare

$110K - $130K *

Unlock potential by providing expert technical support for enterprise clients. You'll bridge engineering and customer success, resolving complex issues, analyzing system performance, and enhancing cli...

United StatesRemote

Reposted 3 days ago

  •   Less than 5 years exp.  •   Information Technology

$154K - $242K *

Transform the clinical trial landscape by leading strategic initiatives that enhance Medical's role in oncology trials, ensuring seamless collaboration and execution across global teams to drive succe...

3 days ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$165K - $264K *

Pioneer cross-functional collaboration to manage IS projects, ensuring successful implementation and support of applications, upgrades, and integrations while overseeing budgets and resources across S...

RemoteRemote

3 days ago

  •   8 - 10 years exp.  •   Healthcare

$170K - $252K *

Transform operational risk management by leading global reviews, enhancing controls, and ensuring compliance. Collaborate with stakeholders to optimize processes and drive quality improvements, delive...

3 days ago

  •   Less than 5 years exp.  •   Finance & Insurance

$180K - $220K *

Shape the future of enterprise technology by leading strategic partnerships and alliances. Drive growth through collaboration with top innovators in software, hardware, and security, while influencing...

United StatesRemote

3 days ago

  •   Less than 5 years exp.  •   Information Technology

$120K - $202K *

Lead the charge in developing robust risk frameworks for a futures clearing business. Collaborate with Trading, Risk Management, and Compliance to establish real-time controls and monitor risks across...

Reposted 3 days ago

  •   8 - 10 years exp.  •   Finance & Insurance

$129K - $230K *

Lead the charge in developing competitive Proposal Staffing Plans for complex Federal proposals, collaborating with cross-functional teams to ensure alignment with technical solutions and compliance w...

United StatesRemote

3 days ago

  •   8 - 10 years exp.  •   Information Technology

Frequently Asked Questions (FAQ)

  • What types of $100,000+ jobs can I find in Massachusetts?question toggle

    Listings may include experienced professional, management, director, vice president, and executive roles across fields such as technology, healthcare, biotechnology, finance, education, and manufacturing. Specific openings and requirements vary.

  • Where in Massachusetts can I find high-paying jobs?question toggle

    Opportunities may be available in Boston, Cambridge, Worcester, Springfield, and other parts of the state. Browse current listings and check each posting for its location and work arrangement.

  • How can I search for Massachusetts jobs paying $100,000 or more?question toggle

    Browse Massachusetts listings on Ladders and refine your search by job title, location, and expertise. Review each posting's compensation information and qualifications.

  • Are Massachusetts jobs on Ladders vetted?question toggle

    Ladders hosts vetted professional job listings. Check the details of each listing to learn about the employer, role, location, compensation, and application requirements.