Find professional opportunities in Massachusetts with salaries of $100,000 or more. From Boston and Cambridge to Worcester, Springfield, and other communities, the state offers a varied job market for experienced professionals seeking their next career move. Browse vetted listings on Ladders and explore roles aligned with your skills, experience, and compensation goals.
Massachusetts is home to employers in industries including biotechnology, healthcare, finance, technology, higher education, consulting, and advanced manufacturing. Opportunities can range from specialized individual-contributor positions to director, vice president, and executive roles. Availability varies by employer and location, so review each listing for its requirements and work arrangement.
Use Ladders to explore high-paying professional jobs and focus your search by title, location, and area of expertise. Review responsibilities and qualifications carefully, then tailor your résumé to highlight relevant achievements, leadership experience, and measurable results.
Whether you are targeting a role in Greater Boston or considering opportunities elsewhere in the state, a focused search can help you identify positions that fit your career priorities. Explore Massachusetts listings on Ladders to take the next step toward a role paying $100,000 or more.
Average Salary: $126,017
Principal Architect, AI Enablement (Houston, TX Preferred OR United States - Remote)
$185K - $235K *
Transform engineering practices by leading AI Enablement initiatives, enhancing workflows, and driving adoption of AI standards across teams. Collaborate with stakeholders to measure progress and deli...
3 days ago
Senior Medical Affairs Operations Manager
$165K - $214K *
Contribute to the success of Medical Affairs by leading project management and operational execution. Collaborate with cross-functional teams to ensure timely delivery of initiatives, manage budgets...
3 days ago
$120K - $145K *
Join the charge in modernizing multi-cloud environments for critical missions. Leverage your expertise in cloud architecture and automation to enhance system resiliency and security while collaboratin...
3 days ago
Senior Bioinformatics Engineer, Infrastructure
$160K - $185K *
Drive innovation in bioinformatics by building robust data pipelines and platforms. Collaborate with scientists to enhance data discoverability and reliability, ensuring impactful contributions across...
3 days ago
$255K - $383K *
Transform enterprise relationships by leading strategic sales initiatives, managing complex cycles, and nurturing partnerships to drive significant revenue growth in a high-impact territory...
3 days ago
Registered Nurse PreOp PACU II, Pool - Atrius Health Ambulatory Surgery Center
$62K - $104K *
Join a team that's dedicated to providing exceptional preoperative and postoperative care. Collaborate with healthcare professionals to assess, implement, and evaluate individualized patient care plan...
3 days ago
Sales Representative (No Cold Calling)
$95K - $250K *
Champion energy efficiency by conducting home assessments, diagnosing issues, and recommending solutions. Drive customer satisfaction through exceptional service and sales techniques while collaborati...
Reposted 3 days ago
Sales Representative (No Cold Calling)
$95K - $250K *
Bring your expertise to enhance energy efficiency for homeowners through assessments, recommendations, and installations. Collaborate with clients to secure contracts and provide exceptional service w...
Reposted 3 days ago
Member of the Technical Staff - Systems ML Engineer
$135K - $160K *
Optimize and enhance ML systems performance across training and inference. Collaborate with research teams to streamline workflows, manage cloud and edge infrastructure, and ensure efficient model dep...
3 days ago
Sales Representative (No Cold Calling)
$95K - $250K *
Elevate your career by engaging homeowners in energy assessments and efficiency upgrades. This role combines consultative sales with hands-on work, offering significant earning potential and rapid car...
Reposted 3 days ago
Technical Delivery and Business Development Lead
$120K - $145K *
Join a team that's redefining technical delivery and business development. Engage with partners to shape innovative solutions, manage complex projects, and drive scientific and commercial value throug...
3 days ago
Registered Nurse PACU II - Atrius Health Ambulatory Surgery Center
$62K - $104K *
Join a team that's dedicated to providing exceptional patient care in the PACU. Utilize your nursing expertise to assess, plan, and implement individualized care while collaborating with a skilled tea...
3 days ago
Optometrist (Recently Updated/Enhanced Pay!)
$162K - $208K *
Join a team that's dedicated to providing exceptional optometry services in nursing homes and assisted living facilities. Enjoy flexible scheduling, competitive compensation, and full administrative s...
3 days ago
Systems Engineer Multiple Levels (cleared)
$99K - $182K *
Transform your career by joining a dynamic team of Systems Engineers focused on developing cutting-edge cybersecurity solutions. Collaborate on mission-critical projects that enhance national security...
3 days ago
$100K - $180K *
Join a team that's transforming therapeutic discovery through innovative computational chemistry. Collaborate with diverse scientists to drive drug development and enhance modeling approaches in a dyn...
3 days ago
$80K - $110K *
Transform financial operations by providing analytical support, enhancing reporting processes, and collaborating with cross-functional teams to drive profitability and efficiency in budgeting and fore...
3 days ago
$124K - $158K *
Contribute to patient care by leading pharmacy operations, ensuring safety, compliance, and quality. Inspire and develop your team while driving growth and improving performance in a dynamic healthcar...
3 days ago
Principal Scientist - Predictive Molecule Design
$166K - $202K *
Lead innovative computational strategies in drug design, integrating structure-based and data-driven approaches to enhance small molecule discovery and advance scientific understanding within multidis...
3 days ago
Senior IT Training and Change Management Specialist
$95K - $115K *
Lead the charge in driving organizational change and training initiatives, collaborating with IT and business teams to enhance technology adoption and user engagement through effective training strate...
3 days ago
$88K - $105K *
Accelerate progress at customer success by managing a diverse portfolio, ensuring product adoption, and driving retention through proactive engagement and collaboration with cross-functional teams...
3 days ago
Regional Medical Director, Value and Access - West
$240K - $280K *
Unlock potential by leading regional medical value strategies and engaging with key healthcare stakeholders. Drive scientific exchange and evidence communication to enhance patient access and support...
3 days ago
Regional Medical Director, Value and Access - West
$240K - $280K *
Drive regional medical value strategy and engage with key healthcare stakeholders to enhance patient access and formulary decisions. Collaborate cross-functionally to translate evidence into impactful...
3 days ago
Sr. Product Marketing Manager - Commercial
$120K - $145K *
Champion the development of impactful sales plays and commercial messaging, driving adoption and field readiness. Collaborate closely with teams to enhance competitive positioning and optimize pricing...
3 days ago
Staff Software Engineer, New Products
$130K - $155K *
Unlock potential by rapidly transforming customer insights into innovative prototypes. Collaborate with a dynamic team to build scalable products from scratch, leveraging AI tools and existing platfor...
3 days ago
Program Manager, Business Continuity & Sustainability
$140K - $160K *
Drive the integration of business continuity and sustainability initiatives, enhancing organizational resilience and environmental performance through strategic planning and cross-functional collabora...
3 days ago
What types of $100,000+ jobs can I find in Massachusetts?
Listings may include experienced professional, management, director, vice president, and executive roles across fields such as technology, healthcare, biotechnology, finance, education, and manufacturing. Specific openings and requirements vary.
Where in Massachusetts can I find high-paying jobs?
Opportunities may be available in Boston, Cambridge, Worcester, Springfield, and other parts of the state. Browse current listings and check each posting for its location and work arrangement.
How can I search for Massachusetts jobs paying $100,000 or more?
Browse Massachusetts listings on Ladders and refine your search by job title, location, and expertise. Review each posting's compensation information and qualifications.
Are Massachusetts jobs on Ladders vetted?
Ladders hosts vetted professional job listings. Check the details of each listing to learn about the employer, role, location, compensation, and application requirements.