Explore $100K+ Jobs in Massachusetts

Find professional opportunities in Massachusetts with salaries of $100,000 or more. From Boston and Cambridge to Worcester, Springfield, and other communities, the state offers a varied job market for experienced professionals seeking their next career move. Browse vetted listings on Ladders and explore roles aligned with your skills, experience, and compensation goals.

Discover Opportunities Across Massachusetts

Massachusetts is home to employers in industries including biotechnology, healthcare, finance, technology, higher education, consulting, and advanced manufacturing. Opportunities can range from specialized individual-contributor positions to director, vice president, and executive roles. Availability varies by employer and location, so review each listing for its requirements and work arrangement.

Find Roles That Match Your Experience

Use Ladders to explore high-paying professional jobs and focus your search by title, location, and area of expertise. Review responsibilities and qualifications carefully, then tailor your résumé to highlight relevant achievements, leadership experience, and measurable results.

Build Your Massachusetts Job Search

Whether you are targeting a role in Greater Boston or considering opportunities elsewhere in the state, a focused search can help you identify positions that fit your career priorities. Explore Massachusetts listings on Ladders to take the next step toward a role paying $100,000 or more.

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1,000+

Jobs in Massachusetts

Average Salary in USD

Average Salary: $126,020

Sort By: Relevance

$118K - $137K *

Join a team that's driving the clean energy transition by analyzing and managing commercial operations for infrastructure projects. Collaborate with senior leaders to ensure compliance, optimize perfo...

United StatesRemote

4 days ago

  •   Less than 5 years exp.  •   Energy & Utilities

$144K - $242K *

Transform the future of listing media by leading strategy and innovation. Collaborate with photographers, agents, and buyers to enhance media experiences, streamline workflows, and drive impactful sol...

United StatesRemote

4 days ago

  •   5 - 7 years exp.  •   Real Estate & Construction

$110K - $130K *

Transform cybersecurity practices by leading vulnerability management and penetration testing efforts. Collaborate with cross-functional teams to enhance security controls, reduce risks, and ensure ro...

RemoteRemote

4 days ago

  •   5 - 7 years exp.  •   Healthcare

$96K - $135K *

Shape the future of business continuity by leading planning and response efforts to ensure seamless operations during disruptions. Collaborate across teams to develop and test recovery strategies that...

United StatesRemote

Reposted 4 days ago

  •   8 - 10 years exp.  •   Finance & Insurance

$145K - $175K *

Lead the charge in engineering management, guiding a cross-functional team of 4-7 engineers. Drive execution, foster growth, and ensure quality while collaborating closely with product management to d...

United StatesRemote

4 days ago

  •   Less than 5 years exp.  •   Enterprise Technology

$120K - $145K *

Drive strategic CMC regulatory leadership for late-stage and marketed products, ensuring compliance and quality in submissions. Collaborate with cross-functional teams to influence outcomes and engage...

United StatesRemote

4 days ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$110K - $130K *

Lead the charge in managing accounting engagements and tax planning for high-net-worth clients, ensuring exceptional service delivery and fostering strong client relationships in a collaborative, remo...

4 days ago

  •   5 - 7 years exp.  •   Legal & Accounting

$125K - $150K *

Lead the charge in optimizing business operations for Harvard Library, overseeing financial management, human resources, and facilities. Collaborate with senior leadership to implement strategic initi...

4 days ago

  •   8 - 10 years exp.  •   Education, Government & Non-Profit

$139K - $170K *

Elevate your career by developing cutting-edge signal processing and machine learning algorithms for electronic warfare and radar systems, working with multidisciplinary teams to transition innovative...

Reposted 4 days ago

  •   Less than 5 years exp.  •   Aerospace & Defense

$248K - $341K *

Elevate your career by driving regional revenue through a sophisticated sales strategy. Own the sales lifecycle, collaborate across teams, and position cutting-edge cybersecurity solutions for SLED cu...

United StatesRemote

4 days ago

  •   5 - 7 years exp.  •   Enterprise Technology

$145K - $155K *

Optimize secure product development practices in medical device software. Lead cybersecurity initiatives, mentor teams, and ensure compliance with global standards while driving innovation and excelle...

4 days ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$145K - $155K *

Lead the advancement of secure product development practices in medical device software, ensuring compliance with global cybersecurity standards while mentoring teams and driving strategic technical d...

4 days ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$187K - $252K *

Lead a high-performing team to drive growth and customer success in the dynamic Betting and Gaming sector, fostering executive relationships and developing strategies for market expansion and resilien...

4 days ago

  •   5 - 7 years exp.  •   Retail & Consumer Goods

$150K - $180K *

Partner with regional leadership to drive financial performance and enhance decision-making. Shape financial strategies, analyze results, and streamline processes to support operational excellence and...

4 days ago

  •   5 - 7 years exp.  •   Real Estate & Construction

$120K - $140K *

Drive transformative client solutions by leading end-to-end implementations of healthcare technology and analytics, ensuring projects align with client goals while managing timelines, quality, and reg...

United StatesRemote

Reposted 4 days ago

  •   Less than 5 years exp.  •   Information Technology

$150K - $250K *

Transform antenna design for cutting-edge consumer products, overseeing the entire process from concept to mass production. Collaborate with cross-functional teams to optimize performance, reliability...

4 days ago

  •   8 - 10 years exp.  •   Consumer Technology

$96K - $151K *

Join a team that's transforming healthcare by developing analytic products from clinical data. Collaborate in an agile environment to deliver insights that enhance efficacy and drive innovation in the...

United StatesRemote

4 days ago

  •   Less than 5 years exp.  •   Healthcare

$222K - $250K *

Champion a high-performing team of Key Account Managers, translating national strategies into regional execution. Drive enterprise engagement with key healthcare networks, ensuring alignment and accou...

4 days ago

  •   15+ years exp.  •   Pharmaceuticals & Biotech

$145K - $175K *

Join us to define and drive the enterprise cloud database strategy, leading architecture and modernization efforts to create scalable, reliable solutions for healthcare applications serving millions o...

United StatesRemote

4 days ago

  •   8 - 10 years exp.  •   Healthcare

$130K - $155K *

Unlock potential as you lead statistical activities for clinical trials, collaborating with cross-functional teams to drive drug development. Utilize advanced statistical methods and oversee programmi...

Cambridge, MARemote

4 days ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$150K - $170K *

Optimize revenue operations by partnering with leadership to enhance GTM strategies, manage HubSpot systems, and drive data quality. Lead analytics and reporting while fostering cross-functional align...

United StatesRemote

4 days ago

  •   8 - 10 years exp.  •   Finance & Insurance

$160K - $220K *

Unlock potential by leading the mechanical design of an autonomous mobile platform, guiding engineers through prototype builds and ensuring robust performance from concept to production certification...

4 days ago

  •   8 - 10 years exp.  •   Manufacturing & Automotive

$62K - $103K *

Drive compliance testing initiatives by executing risk-based assessments, ensuring adherence to regulations across lending activities. Collaborate with teams to identify control weaknesses and enhance...

4 days ago

  •   Less than 5 years exp.  •   Finance & Insurance

$110K - $130K *

Champion patient access by providing education and support to patients, caregivers, and healthcare professionals, ensuring seamless therapy access and enhancing patient experiences through strategic c...

4 days ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$110K - $130K *

Transform patient access by providing education and support to patients, caregivers, and healthcare professionals. Collaborate across teams to minimize barriers and enhance the experience for those re...

Waltham, MARemote

4 days ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

Frequently Asked Questions (FAQ)

  • What types of $100,000+ jobs can I find in Massachusetts?question toggle

    Listings may include experienced professional, management, director, vice president, and executive roles across fields such as technology, healthcare, biotechnology, finance, education, and manufacturing. Specific openings and requirements vary.

  • Where in Massachusetts can I find high-paying jobs?question toggle

    Opportunities may be available in Boston, Cambridge, Worcester, Springfield, and other parts of the state. Browse current listings and check each posting for its location and work arrangement.

  • How can I search for Massachusetts jobs paying $100,000 or more?question toggle

    Browse Massachusetts listings on Ladders and refine your search by job title, location, and expertise. Review each posting's compensation information and qualifications.

  • Are Massachusetts jobs on Ladders vetted?question toggle

    Ladders hosts vetted professional job listings. Check the details of each listing to learn about the employer, role, location, compensation, and application requirements.