Explore $100K+ Jobs in Massachusetts

Find professional opportunities in Massachusetts with salaries of $100,000 or more. From Boston and Cambridge to Worcester, Springfield, and other communities, the state offers a varied job market for experienced professionals seeking their next career move. Browse vetted listings on Ladders and explore roles aligned with your skills, experience, and compensation goals.

Discover Opportunities Across Massachusetts

Massachusetts is home to employers in industries including biotechnology, healthcare, finance, technology, higher education, consulting, and advanced manufacturing. Opportunities can range from specialized individual-contributor positions to director, vice president, and executive roles. Availability varies by employer and location, so review each listing for its requirements and work arrangement.

Find Roles That Match Your Experience

Use Ladders to explore high-paying professional jobs and focus your search by title, location, and area of expertise. Review responsibilities and qualifications carefully, then tailor your résumé to highlight relevant achievements, leadership experience, and measurable results.

Build Your Massachusetts Job Search

Whether you are targeting a role in Greater Boston or considering opportunities elsewhere in the state, a focused search can help you identify positions that fit your career priorities. Explore Massachusetts listings on Ladders to take the next step toward a role paying $100,000 or more.

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1,000+

Jobs in Massachusetts

Average Salary in USD

Average Salary: $126,020

Sort By: Relevance

$120K - $145K *

Join a team that's leading complex global clinical trials, overseeing execution, budgets, and quality. Leverage your expertise in clinical operations to drive study success from planning through close...

4 days ago

  •   8 - 10 years exp.  •   Staffing

$170K - $260K *

Oversee the global Digital Operations Center, driving operational strategy and incident management while leading a multi-site team to enhance monitoring and response capabilities across regions...

4 days ago

  •   8 - 10 years exp.  •   Information Technology

$160K - $200K *

Drive growth by leading strategic partnerships in healthcare tech. Collaborate with executives to shape joint strategies, negotiate impactful deals, and operationalize go-to-market initiatives that en...

United StatesRemote

4 days ago

  •   5 - 7 years exp.  •   Healthcare

$120K - $155K *

Champion data-driven insights to enhance Digital Commerce performance. Leverage analytics to optimize pricing, promotions, and strategy for both direct-to-consumer and marketplace channels, driving bo...

Reposted 4 days ago

  •   Less than 5 years exp.  •   Consumer Technology

$110K - $130K *

Lead the charge in evolving and executing a compelling brand identity that drives measurable results across digital, advertising, and event channels, while leveraging AI tools to enhance creative prod...

RemoteRemote

4 days ago

  •   5 - 7 years exp.  •   Media

$100K - $150K *

Unlock potential by driving B2B sales for innovative payment solutions. Manage the full sales cycle, engage with clients, and leverage technology to enhance business operations. Thrive in a dynamic en...

4 days ago

  •   Less than 5 years exp.  •   Finance & Insurance

$116K - $145K *

Join a dedicated team to provide high-quality patient care in a dynamic NICU environment. Utilize your advanced skills to assess, diagnose, and treat patients while collaborating with healthcare profe...

4 days ago

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$75K - $90K *

Optimize laboratory operations by supporting engineers in testing, troubleshooting, and maintaining equipment. Collaborate with cross-functional teams to enhance efficiency and ensure accurate data co...

4 days ago

  •   Less than 5 years exp.  •   Enterprise Technology

$142K - $202K *

Unlock commercial potential by executing transformation workstreams, collaborating with cross-functional teams, and delivering strategic insights to drive measurable results in a healthcare-focused en...

United StatesRemote

4 days ago

  •   Less than 5 years exp.  •   Healthcare

$120K *

Unlock potential by providing specialized PM&R services in a collaborative environment. Work closely with interdisciplinary teams to enhance patient outcomes and independence in a skilled nursing faci...

4 days ago

  •   Less than 5 years exp.  •   Healthcare

$150K - $180K *

Elevate AI experiences from concept to value by collaborating with engineering and design teams. Drive strategy, build prototypes, and make data-driven decisions to enhance user engagement and product...

United StatesRemote

4 days ago

  •   5 - 7 years exp.  •   Enterprise Technology

$160K - $200K *

Transform client relationships by driving business growth, securing profitable projects, and leveraging market access expertise. Lead teams to exceed expectations while identifying industry trends and...

United StatesRemote

4 days ago

  •   Less than 5 years exp.  •   Healthcare

$125K - $155K *

Shape the future of manufacturing by leading customer-focused projects that enhance operational efficiency. Collaborate with diverse teams to implement innovative solutions, ensuring high-quality outc...

4 days ago

  •   5 - 7 years exp.  •   Enterprise Technology

$165K - $220K *

Join a team that's redefining avionics systems engineering by translating customer needs into innovative architectures and requirements. Collaborate across domains to deliver high-quality solutions in...

United StatesRemote

4 days ago

  •   8 - 10 years exp.  •   Aerospace & Defense

$165K - $220K *

Join a team that's redefining avionics systems engineering by translating customer needs into robust architectures and requirements. Collaborate across domains to deliver high-quality, safety-critical...

4 days ago

  •   8 - 10 years exp.  •   Aerospace & Defense

$150K - $180K *

Drive your career with a strategic sales leadership role focused on enterprise growth in healthcare. Lead complex business development efforts, build executive relationships, and shape solutions that...

United StatesRemote

4 days ago

  •   8 - 10 years exp.  •   Healthcare

$114K - $180K *

Join a team that's dedicated to delivering exceptional primary care services to psychiatric patients. This role requires independent practice and collaboration with a committed treatment team, ensurin...

4 days ago

  •   Less than 5 years exp.  •   Healthcare

$130K - $155K *

Lead the AI/ML product strategy across multiple business units, driving integration and data-centric solutions that enhance customer value and revenue growth through innovative workflows and collabora...

United StatesRemote

4 days ago

  •   5 - 7 years exp.  •   Healthcare

$175K - $210K *

Lead operational excellence in biopharmaceutical manufacturing, overseeing GMP processes, technology transfers, and clinical supply. Drive strategic initiatives, manage CDMO relationships, and build a...

United StatesRemote

4 days ago

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

$170K - $220K *

Pioneer data-driven decision-making by leading our data science practice. Collaborate with cross-functional teams to build scalable analytics frameworks and transform complex data into actionable insi...

Boston, MARemote

Reposted 4 days ago

  •   5 - 7 years exp.  •   Staffing

$170K - $220K *

Unlock potential by leading the data science function, transforming complex datasets into actionable insights. Collaborate with cross-functional teams to design analytics frameworks and drive strategi...

Boston, MARemote

Reposted 4 days ago

  •   5 - 7 years exp.  •   Staffing

$160K - $190K *

Pioneer innovative solutions in cloud-native architecture and enterprise technology. Lead architecture initiatives, mentor teams, and drive strategic technology decisions in a dynamic financial servic...

Reposted 4 days ago

  •   11 - 15 years exp.  •   Staffing

$100K - $120K *

Drive engineering excellence in product development and process optimization, ensuring seamless transition to manufacturing while enhancing operational efficiency and compliance with industry standard...

4 days ago

  •   5 - 7 years exp.  •   Healthcare

$106K - $146K *

Shape the future of our operations by leading a dynamic team to optimize Quote-to-Cash strategies, enhance analytics, and design streamlined workflows, all while collaborating across functions to driv...

United StatesRemote

Reposted 4 days ago

  •   5 - 7 years exp.  •   Enterprise Technology

$64K - $108K *

Innovate patient care as an Outpatient RN, coordinating treatment and education for ESKD patients. Collaborate with a healthcare team to enhance outcomes and ensure safe hemodialysis delivery while ad...

Reposted 4 days ago

  •   Less than 5 years exp.  •   Healthcare

Frequently Asked Questions (FAQ)

  • What types of $100,000+ jobs can I find in Massachusetts?question toggle

    Listings may include experienced professional, management, director, vice president, and executive roles across fields such as technology, healthcare, biotechnology, finance, education, and manufacturing. Specific openings and requirements vary.

  • Where in Massachusetts can I find high-paying jobs?question toggle

    Opportunities may be available in Boston, Cambridge, Worcester, Springfield, and other parts of the state. Browse current listings and check each posting for its location and work arrangement.

  • How can I search for Massachusetts jobs paying $100,000 or more?question toggle

    Browse Massachusetts listings on Ladders and refine your search by job title, location, and expertise. Review each posting's compensation information and qualifications.

  • Are Massachusetts jobs on Ladders vetted?question toggle

    Ladders hosts vetted professional job listings. Check the details of each listing to learn about the employer, role, location, compensation, and application requirements.