Find $100K+ Jobs in Massachusetts

Explore professional opportunities across Massachusetts with Ladders. Browse vetted jobs paying $100,000 or more, from roles in Boston and Cambridge to opportunities in Worcester, Springfield, and other communities throughout the state. Whether you’re pursuing your next leadership position or advancing your career in a specialized field, discover openings that match your experience and goals.

Explore Massachusetts Career Opportunities

Massachusetts is home to a diverse economy with employers in technology, healthcare, financial services, education, biotechnology, manufacturing, and professional services. Job availability and compensation vary by employer, role, and experience. Use Ladders to explore current openings and identify opportunities aligned with your skills.

Search by Location and Specialty

Focus your search on major employment centers such as Boston, Cambridge, and Worcester, or look across the state for roles that fit your preferences. Refine your search by job title, industry, seniority, and other relevant criteria to find opportunities suited to your career direction.

Advance Your Career with Ladders

Ladders specializes in vetted professional jobs paying $100,000 or more. Review listings, compare role requirements, and apply to positions that align with your qualifications. Set up a complete profile and keep your resume current to make it easier to pursue your next Massachusetts opportunity.

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1,000+

Jobs in Massachusetts

Average Salary in USD

Average Salary: $125,890

Sort By: Relevance

$125K - $168K *

Pioneer application modernization efforts by leading agile teams, driving technical outcomes, and enhancing developer experiences. Collaborate with clients to deliver measurable business results while...

United StatesRemote

Yesterday

  •   5 - 7 years exp.  •   Information Technology

$120K - $145K *

Join a team that's leading complex global clinical trials, overseeing execution, budgets, and quality. Leverage your expertise in clinical operations to drive study success from planning through close...

Yesterday

  •   8 - 10 years exp.  •   Staffing

$170K - $260K *

Oversee the global Digital Operations Center, driving operational strategy and incident management while leading a multi-site team to enhance monitoring and response capabilities across regions...

Yesterday

  •   8 - 10 years exp.  •   Information Technology

$160K - $200K *

Drive growth by leading strategic partnerships in healthcare tech. Collaborate with executives to shape joint strategies, negotiate impactful deals, and operationalize go-to-market initiatives that en...

United StatesRemote

Yesterday

  •   5 - 7 years exp.  •   Healthcare

$120K - $155K *

Champion data-driven insights to enhance Digital Commerce performance. Leverage analytics to optimize pricing, promotions, and strategy for both direct-to-consumer and marketplace channels, driving bo...

Reposted yesterday

  •   Less than 5 years exp.  •   Consumer Technology

$110K - $130K *

Lead the charge in evolving and executing a compelling brand identity that drives measurable results across digital, advertising, and event channels, while leveraging AI tools to enhance creative prod...

RemoteRemote

Yesterday

  •   5 - 7 years exp.  •   Media

$100K - $150K *

Unlock potential by driving B2B sales for innovative payment solutions. Manage the full sales cycle, engage with clients, and leverage technology to enhance business operations. Thrive in a dynamic en...

Yesterday

  •   Less than 5 years exp.  •   Finance & Insurance

$116K - $145K *

Join a dedicated team to provide high-quality patient care in a dynamic NICU environment. Utilize your advanced skills to assess, diagnose, and treat patients while collaborating with healthcare profe...

Yesterday

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$110K - $130K *

Unlock potential by driving the full sales cycle, engaging prospects, and closing strategic deals. Build trusted relationships in a fast-paced environment, contributing to growth in the cloud security...

Yesterday

  •   5 - 7 years exp.  •   Information Technology

$75K - $90K *

Optimize laboratory operations by supporting engineers in testing, troubleshooting, and maintaining equipment. Collaborate with cross-functional teams to enhance efficiency and ensure accurate data co...

Yesterday

  •   Less than 5 years exp.  •   Enterprise Technology

$142K - $202K *

Unlock commercial potential by executing transformation workstreams, collaborating with cross-functional teams, and delivering strategic insights to drive measurable results in a healthcare-focused en...

United StatesRemote

Yesterday

  •   Less than 5 years exp.  •   Healthcare

$120K *

Unlock potential by providing specialized PM&R services in a collaborative environment. Work closely with interdisciplinary teams to enhance patient outcomes and independence in a skilled nursing faci...

Yesterday

  •   Less than 5 years exp.  •   Healthcare

$150K - $180K *

Elevate AI experiences from concept to value by collaborating with engineering and design teams. Drive strategy, build prototypes, and make data-driven decisions to enhance user engagement and product...

United StatesRemote

Yesterday

  •   5 - 7 years exp.  •   Enterprise Technology

$160K - $200K *

Transform client relationships by driving business growth, securing profitable projects, and leveraging market access expertise. Lead teams to exceed expectations while identifying industry trends and...

United StatesRemote

Yesterday

  •   Less than 5 years exp.  •   Healthcare

$125K - $155K *

Shape the future of manufacturing by leading customer-focused projects that enhance operational efficiency. Collaborate with diverse teams to implement innovative solutions, ensuring high-quality outc...

Yesterday

  •   5 - 7 years exp.  •   Enterprise Technology

$165K - $220K *

Join a team that's redefining avionics systems engineering by translating customer needs into innovative architectures and requirements. Collaborate across domains to deliver high-quality solutions in...

United StatesRemote

Yesterday

  •   8 - 10 years exp.  •   Aerospace & Defense

$165K - $220K *

Join a team that's redefining avionics systems engineering by translating customer needs into robust architectures and requirements. Collaborate across domains to deliver high-quality, safety-critical...

Yesterday

  •   8 - 10 years exp.  •   Aerospace & Defense

$150K - $180K *

Drive your career with a strategic sales leadership role focused on enterprise growth in healthcare. Lead complex business development efforts, build executive relationships, and shape solutions that...

United StatesRemote

Yesterday

  •   8 - 10 years exp.  •   Healthcare

$114K - $180K *

Join a team that's dedicated to delivering exceptional primary care services to psychiatric patients. This role requires independent practice and collaboration with a committed treatment team, ensurin...

Yesterday

  •   Less than 5 years exp.  •   Healthcare

$130K - $155K *

Lead the AI/ML product strategy across multiple business units, driving integration and data-centric solutions that enhance customer value and revenue growth through innovative workflows and collabora...

United StatesRemote

Yesterday

  •   5 - 7 years exp.  •   Healthcare

$175K - $210K *

Lead operational excellence in biopharmaceutical manufacturing, overseeing GMP processes, technology transfers, and clinical supply. Drive strategic initiatives, manage CDMO relationships, and build a...

United StatesRemote

Yesterday

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

$170K - $220K *

Pioneer data-driven decision-making by leading our data science practice. Collaborate with cross-functional teams to build scalable analytics frameworks and transform complex data into actionable insi...

Boston, MARemote

Reposted yesterday

  •   5 - 7 years exp.  •   Staffing

$170K - $220K *

Unlock potential by leading the data science function, transforming complex datasets into actionable insights. Collaborate with cross-functional teams to design analytics frameworks and drive strategi...

Boston, MARemote

Reposted yesterday

  •   5 - 7 years exp.  •   Staffing

$160K - $190K *

Pioneer innovative solutions in cloud-native architecture and enterprise technology. Lead architecture initiatives, mentor teams, and drive strategic technology decisions in a dynamic financial servic...

Reposted yesterday

  •   11 - 15 years exp.  •   Staffing

$100K - $120K *

Drive engineering excellence in product development and process optimization, ensuring seamless transition to manufacturing while enhancing operational efficiency and compliance with industry standard...

Yesterday

  •   5 - 7 years exp.  •   Healthcare

Frequently Asked Questions (FAQ)

  • What types of $100,000+ jobs can I find in Massachusetts?question toggle

    Listings may include professional and leadership roles across fields such as technology, healthcare, finance, biotechnology, education, manufacturing, and business services. Available positions change, so browse current listings for the latest opportunities.

  • Where can I find professional jobs in Massachusetts?question toggle

    Search across the state, including major employment centers such as Boston, Cambridge, and Worcester. You can also use location filters to explore roles in other Massachusetts communities.

  • Are the Massachusetts jobs on Ladders vetted?question toggle

    Ladders features vetted professional job listings paying $100,000 or more. Review each listing for details about the employer, responsibilities, qualifications, and compensation.

  • How can I find a Massachusetts job that matches my experience?question toggle

    Use filters such as location, job title, industry, and seniority to narrow your search. Keep your resume current and compare each listing’s requirements with your skills and career goals.