Explore $100K+ Jobs in Kentucky

Find vetted professional opportunities paying $100,000 or more across Kentucky with Ladders. From Louisville and Lexington to growing communities throughout the state, explore roles for experienced professionals ready to take the next step in their careers. Browse openings across industries and compare opportunities that match your skills, experience, and goals.

Professional Opportunities Across Kentucky

Kentucky’s economy includes established sectors such as healthcare, manufacturing, logistics, finance, and technology, alongside growing businesses and regional employers. Opportunities vary by location and experience, with roles in corporate leadership, operations, sales, engineering, healthcare administration, and other professional fields. Review each listing for location, qualifications, compensation details, and work arrangement.

Find the Right Role for Your Experience

Use Ladders to focus your search on vetted jobs with salaries of at least $100,000. Explore positions by title, employer, location, or industry, and consider opportunities in major employment centers as well as other parts of Kentucky. Tailor your resume to each role and highlight measurable results, relevant expertise, and leadership experience.

Advance Your Career in Kentucky

Whether you are planning a career move within Kentucky or considering relocating to the state, compare openings and employer requirements to identify a strong fit. New listings and hiring needs can change, so check back regularly for current $100K+ professional opportunities.

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1,000+

Jobs in Kentucky

Average Salary in USD

Average Salary: $108,152

Sort By: Relevance

$230K - $290K *

Pioneer the future of checkout experiences by leading frontend engineering initiatives. Collaborate across teams to set technical strategies, enhance operational processes, and foster a culture of qua...

United StatesRemote

5 days ago

  •   8 - 10 years exp.  •   Finance & Insurance

$170K - $200K *

Shape the future of finance transformation by prioritizing systems requests and process improvements. Collaborate across teams to enhance operations and drive impactful change in a fast-paced, dynamic...

United StatesRemote

5 days ago

  •   8 - 10 years exp.  •   Consumer Technology

$235K - $270K *

Join a team that's driving access strategy across the Northeast, managing key payer relationships and ensuring launch readiness for rare disease therapies. Collaborate with cross-functional teams to o...

United StatesRemote

5 days ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$125K - $150K *

Drive operational excellence and strategic growth across gaming and hospitality properties, ensuring compliance, guest satisfaction, and team engagement while maximizing revenue and market share throu...

Reposted 5 days ago

  •   8 - 10 years exp.  •   Media

$90K - $120K *

Deliver exceptional sales performance by managing territory relationships and driving growth through effective product promotion and client engagement in the electrical industry...

United StatesRemote

Reposted 5 days ago

  •   Less than 5 years exp.  •   Manufacturing & Automotive

$108K - $130K *

Champion the development of Planning and Inventory strategies, leading a team to optimize supply chain performance and ensure compliance. Drive process improvements and manage supplier relationships t...

RemoteRemote

Reposted 5 days ago

  •   8 - 10 years exp.  •   Manufacturing & Automotive

$110K - $130K *

Lead the charge in optimizing physical therapy operations, enhancing care quality and access through strategic resource allocation and team development. Collaborate across clinical functions to drive...

United StatesRemote

5 days ago

  •   5 - 7 years exp.  •   Hospitality & Recreation

$200K - $240K *

Unlock potential by leading performance marketing initiatives to drive qualified customer acquisition through innovative digital strategies and collaboration with cross-functional teams...

United StatesRemote

5 days ago

  •   8 - 10 years exp.  •   Finance & Insurance

$70K - $97K *

Analyze manufacturing processes for sheet glass production, leading efforts to optimize efficiency, enhance quality, and solve production challenges across multiple lines while driving innovation in t...

Reposted 5 days ago

  •   Less than 5 years exp.  •   Manufacturing & Automotive

$200K - $220K *

Innovate high-performance services by collaborating with engineers to design, implement, and optimize scalable systems, ensuring reliability and efficiency in a distributed environment...

United StatesRemote

5 days ago

  •   8 - 10 years exp.  •   Enterprise Technology

$105K - $125K *

Drive your career forward by cultivating relationships and achieving growth in enterprise accounts. Leverage your sales expertise to influence decision-makers and deliver tailored solutions across div...

United StatesRemote

5 days ago

  •   5 - 7 years exp.  •   Information Technology

$186K - $233K *

Shape impactful marketing strategies for lung cancer programs, collaborating with cross-functional teams to drive patient engagement and launch readiness. Lead initiatives that align with brand goals...

United StatesRemote

5 days ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$100K - $120K *

Join a team that's driving innovation in business development, fostering relationships with customers and partners to identify growth opportunities in the chemicals industry while managing the full li...

United StatesRemote

Reposted 5 days ago

  •   Less than 5 years exp.  •   Manufacturing & Automotive

$203K - $245K *

Unlock potential by leading a national team of Thought Leader Liaisons to enhance KOL engagement and advocacy in oncology. Drive strategic initiatives, foster collaboration, and ensure compliance whil...

RemoteRemote

Reposted 5 days ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$110K - $130K *

Unlock advanced security analytics by leveraging your expertise to enhance incident response capabilities. Collaborate with cross-functional teams to develop scalable solutions and mitigate risks whil...

United StatesRemote

Reposted 5 days ago

  •   Less than 5 years exp.  •   Finance & Insurance

$140K - $160K *

Lead the charge in executing compliance activities, driving risk management, and enhancing governance processes. Collaborate across functions to deliver insights and improvements, ensuring adherence t...

Reposted 5 days ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$82K - $150K *

Drive growth by aggressively prospecting and converting new dental accounts while expanding existing relationships. Leverage a hunter mentality to position value-oriented implant solutions and achieve...

United StatesRemote

Reposted 5 days ago

  •   Less than 5 years exp.  •   Healthcare

$90K - $100K *

Drive your career forward by delivering actionable insights and strategies that enhance client media performance. Collaborate with cross-functional teams to craft compelling narratives and optimize me...

United StatesRemote

5 days ago

  •   Less than 5 years exp.  •   Media

$200K - $300K *

Join a team that's redefining marketing strategy in the DeFi space. Lead a senior marketing team, drive growth for innovative products, and shape brand narratives while collaborating closely with sale...

United StatesRemote

5 days ago

  •   8 - 10 years exp.  •   Information Technology

$95K - $115K *

Elevate your career by leading a talented engineering team to develop innovative manufacturing processes, drive Lean initiatives, and improve production quality, ensuring efficiency and success in pro...

Reposted 5 days ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$100K - $120K *

Lead the charge in enhancing fire protection systems for nuclear facilities while collaborating with engineering teams, ensuring compliance with regulations, and supporting modifications that safeguar...

United StatesRemote

Reposted 5 days ago

  •   5 - 7 years exp.  •   Energy & Utilities

$120K - $145K *

Drive customer success by managing the post-sales lifecycle, implementing solutions, and troubleshooting technical issues for strategic clients, ensuring they maximize value from Teleport products and...

United StatesRemote

5 days ago

  •   8 - 10 years exp.  •   Information Technology

$120K - $145K *

Unlock your potential as a legal business partner, driving innovation in product and partner strategies. Collaborate with cross-functional teams to navigate legal complexities in a fast-paced tech env...

United StatesRemote

5 days ago

  •   Less than 5 years exp.  •   Enterprise Technology

$79K - $103K *

Lead the Facilities team to ensure maintenance operations comply with OSHA standards, optimizing equipment performance in a fast-paced healthcare environment. Collaborate with team members on continuo...

Reposted 5 days ago

  •   5 - 7 years exp.  •   Healthcare

$74K - $100K *

Drive continuous improvement and optimize factory performance by collaborating with leadership and shop floor teams to implement Total Performance Management (TPM) strategies, fostering a culture of o...

Reposted 5 days ago

  •   Less than 5 years exp.  •   Food & Beverages

Frequently Asked Questions (FAQ)

  • Where can I find jobs paying $100,000 or more in Kentucky?question toggle

    Browse Ladders for vetted professional openings in Kentucky with salaries of $100,000 or more. Search by job title, employer, industry, or location to narrow your options.

  • What types of high-paying professional jobs are available in Kentucky?question toggle

    Opportunities may include leadership, healthcare administration, manufacturing, logistics, finance, technology, sales, and engineering roles. Availability and qualifications vary by employer and location.

  • Which Kentucky cities have professional job opportunities?question toggle

    Louisville and Lexington are major employment centers, and professional openings may also be available in other Kentucky communities. Check individual listings for the job location and work arrangement.

  • How can I improve my chances of getting a $100K+ job in Kentucky?question toggle

    Target roles that closely match your experience, tailor your resume to the job requirements, and emphasize measurable achievements, specialized expertise, and leadership impact.

  • Are all jobs listed in Kentucky remote or hybrid?question toggle

    Work arrangements vary by position and employer. Review each listing to see whether the role is onsite, hybrid, or remote.