Explore $100K+ Jobs in Kentucky

Find vetted professional opportunities paying $100,000 or more across Kentucky with Ladders. From Louisville and Lexington to growing communities throughout the state, explore roles for experienced professionals ready to take the next step in their careers. Browse openings across industries and compare opportunities that match your skills, experience, and goals.

Professional Opportunities Across Kentucky

Kentucky’s economy includes established sectors such as healthcare, manufacturing, logistics, finance, and technology, alongside growing businesses and regional employers. Opportunities vary by location and experience, with roles in corporate leadership, operations, sales, engineering, healthcare administration, and other professional fields. Review each listing for location, qualifications, compensation details, and work arrangement.

Find the Right Role for Your Experience

Use Ladders to focus your search on vetted jobs with salaries of at least $100,000. Explore positions by title, employer, location, or industry, and consider opportunities in major employment centers as well as other parts of Kentucky. Tailor your resume to each role and highlight measurable results, relevant expertise, and leadership experience.

Advance Your Career in Kentucky

Whether you are planning a career move within Kentucky or considering relocating to the state, compare openings and employer requirements to identify a strong fit. New listings and hiring needs can change, so check back regularly for current $100K+ professional opportunities.

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1,000+

Jobs in Kentucky

Average Salary in USD

Average Salary: $108,152

Sort By: Relevance

$123K - $168K *

Engage with healthcare professionals to drive product growth and acceptance. Build lasting relationships, educate stakeholders, and collaborate cross-functionally to enhance market presence and uphold...

United StatesRemote

4 days ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$155K - $258K *

Shape the future of AI in healthcare by leading architectural design and technical strategy for LLM-powered systems. Mentor engineers, ensure compliance, and drive innovation in a highly regulated env...

United StatesRemote

4 days ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$105K - $120K *

Drive the substantiation of health claims for dietary supplements by reviewing scientific evidence and collaborating with cross-functional teams to ensure compliance with regulatory standards and enha...

United StatesRemote

4 days ago

  •   Less than 5 years exp.  •   Technical Services

$156K - $281K *

Drive innovative solutions by leading complex Federal acquisitions, guiding cross-functional teams, and delivering high-quality proposals. Leverage technical expertise to elevate win probability and e...

United StatesRemote

4 days ago

  •   11 - 15 years exp.  •   Information Technology

$77K - $108K *

Drive the implementation and support of AI workload orchestration platforms, ensuring high-quality technical outcomes in client environments. Collaborate across teams to deliver reliable, secure acces...

United StatesRemote

4 days ago

  •   Less than 5 years exp.  •   Information Technology

$100K - $125K *

Elevate your career by leading complex proposals and marketing initiatives. Drive innovation in AI and modern practices while collaborating with diverse teams to create compelling communications for a...

4 days ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$255K - $345K *

Join a team that's redefining cybersecurity by integrating AI capabilities. Leverage your 15+ years of experience to drive innovation, collaborate with cross-functional teams, and deliver mission-crit...

RemoteRemote

4 days ago

  •   11 - 15 years exp.  •   Information Technology

$100K - $170K *

Drive the evolution of Legal Operations analytics by building scalable data capabilities, modernizing reporting, integrating AI, and establishing predictive models to enhance decision-making and opera...

United StatesRemote

Reposted 4 days ago

  •   5 - 7 years exp.  •   Finance & Insurance

$80K - $95K *

Join us to design and deploy enterprise wireless networks across diverse sectors. Collaborate with clients and teams to ensure project success while providing technical support and troubleshooting in...

United StatesRemote

4 days ago

  •   Less than 5 years exp.  •   Information Technology

$95K - $115K *

Elevate your career by developing innovative solutions within the Infor LN platform. Collaborate with cross-functional teams to enhance payment processing capabilities and create seamless integrations...

United StatesRemote

4 days ago

  •   Less than 5 years exp.  •   Finance & Insurance

$80K - $95K *

Transform patient access by optimizing Epic Cadence workflows. Collaborate with clinical teams to enhance scheduling efficiency and support system improvements, ensuring seamless operations and superi...

United StatesRemote

4 days ago

  •   Less than 5 years exp.  •   Healthcare

$100K - $120K *

Drive operational excellence by leading Hub programs, enhancing performance metrics, and developing Supervisors. Collaborate cross-functionally to ensure effective service delivery and continuous impr...

United StatesRemote

4 days ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$70K - $119K *

Optimize operational efficiency by analyzing performance metrics, supporting training, and enhancing tool adoption within the Business Development Representative organization to drive productivity and...

United StatesRemote

4 days ago

  •   Less than 5 years exp.  •   Finance & Insurance

$148K - $247K *

Empower growth by leading dealer operations, driving market share, and enhancing dealer satisfaction. Oversee P&L, optimize processes, and collaborate across teams to ensure operational excellence and...

United StatesRemote

4 days ago

  •   11 - 15 years exp.  •   Transportation

$170K - $205K *

Drive the development of safety-critical autonomous systems, ensuring robust safety performance through hazard analysis and collaboration with cross-functional teams. Contribute to innovative solution...

United StatesRemote

4 days ago

  •   8 - 10 years exp.  •   Aerospace & Defense

$108K - $130K *

Unlock potential by leading strategic growth in the North American mining sector. Drive customer relationships, integrate solutions, and enhance market presence while collaborating across teams to del...

4 days ago

  •   8 - 10 years exp.  •   Manufacturing & Automotive

$124K - $155K *

Lead the successful execution of projects by managing teams, fostering collaboration, and ensuring adherence to methodologies. Drive talent development and build strong relationships across functions...

United StatesRemote

4 days ago

  •   5 - 7 years exp.  •   Information Technology

$90K - $110K *

Elevate your career by managing accounting activities, ensuring compliance, and collaborating across teams to enhance financial accuracy and internal controls in a dynamic environment...

United StatesRemote

4 days ago

  •   Less than 5 years exp.  •   Legal & Accounting

$95K - $115K *

Contribute to revenue growth by selling innovative traffic management solutions to government agencies. Build strategic partnerships, identify opportunities, and execute sales strategies to meet ambit...

United StatesRemote

4 days ago

  •   5 - 7 years exp.  •   Transportation

$100K - $120K *

Transform traffic management by driving revenue through strategic partnerships with government agencies. Collaborate with teams to identify opportunities, tailor solutions, and achieve growth objectiv...

United StatesRemote

4 days ago

  •   5 - 7 years exp.  •   Transportation

$100K - $120K *

Shape the future of traffic management by driving revenue through strategic partnerships with government agencies. Cultivate relationships, identify opportunities, and execute sales strategies to meet...

United StatesRemote

4 days ago

  •   5 - 7 years exp.  •   Transportation

$83K - $147K *

Join a team that's dedicated to ensuring high-quality digital solutions through comprehensive testing strategies. Collaborate with cross-functional teams to enhance software quality and drive continuo...

United StatesRemote

4 days ago

  •   8 - 10 years exp.  •   Manufacturing & Automotive

$272K - $431K *

Join a team that's redefining cloud-native technologies by managing innovative engineering efforts in container orchestration and GPU acceleration, ensuring seamless integration across platforms while...

United StatesRemote

Reposted 4 days ago

  •   11 - 15 years exp.  •   Manufacturing & Automotive

$80K - $95K *

Unlock potential by managing financial accuracy and insights, overseeing month-end close, budgeting, and project accounting. Collaborate closely with the Controller to ensure compliance and streamline...

United StatesRemote

4 days ago

  •   Less than 5 years exp.  •   Enterprise Technology

$175K - $225K *

Transform your career by leading the engineering design of a cutting-edge SCADA program for a hybrid energy facility. Collaborate with multidisciplinary teams to ensure seamless integration and compli...

United StatesRemote

4 days ago

  •   8 - 10 years exp.  •   Technical Services

Frequently Asked Questions (FAQ)

  • Where can I find jobs paying $100,000 or more in Kentucky?question toggle

    Browse Ladders for vetted professional openings in Kentucky with salaries of $100,000 or more. Search by job title, employer, industry, or location to narrow your options.

  • What types of high-paying professional jobs are available in Kentucky?question toggle

    Opportunities may include leadership, healthcare administration, manufacturing, logistics, finance, technology, sales, and engineering roles. Availability and qualifications vary by employer and location.

  • Which Kentucky cities have professional job opportunities?question toggle

    Louisville and Lexington are major employment centers, and professional openings may also be available in other Kentucky communities. Check individual listings for the job location and work arrangement.

  • How can I improve my chances of getting a $100K+ job in Kentucky?question toggle

    Target roles that closely match your experience, tailor your resume to the job requirements, and emphasize measurable achievements, specialized expertise, and leadership impact.

  • Are all jobs listed in Kentucky remote or hybrid?question toggle

    Work arrangements vary by position and employer. Review each listing to see whether the role is onsite, hybrid, or remote.