Explore $100K+ Jobs in Kentucky

Find vetted professional opportunities paying $100,000 or more across Kentucky with Ladders. From Louisville and Lexington to growing communities throughout the state, explore roles for experienced professionals ready to take the next step in their careers. Browse openings across industries and compare opportunities that match your skills, experience, and goals.

Professional Opportunities Across Kentucky

Kentucky’s economy includes established sectors such as healthcare, manufacturing, logistics, finance, and technology, alongside growing businesses and regional employers. Opportunities vary by location and experience, with roles in corporate leadership, operations, sales, engineering, healthcare administration, and other professional fields. Review each listing for location, qualifications, compensation details, and work arrangement.

Find the Right Role for Your Experience

Use Ladders to focus your search on vetted jobs with salaries of at least $100,000. Explore positions by title, employer, location, or industry, and consider opportunities in major employment centers as well as other parts of Kentucky. Tailor your resume to each role and highlight measurable results, relevant expertise, and leadership experience.

Advance Your Career in Kentucky

Whether you are planning a career move within Kentucky or considering relocating to the state, compare openings and employer requirements to identify a strong fit. New listings and hiring needs can change, so check back regularly for current $100K+ professional opportunities.

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1,000+

Jobs in Kentucky

Average Salary in USD

Average Salary: $108,152

Sort By: Relevance

$57K - $178K *

Champion the administration of estates and trusts, ensuring compliance and accuracy in tax filings while managing client relationships and case documentation. Leverage your expertise to deliver except...

United StatesRemote

3 days ago

  •   8 - 10 years exp.  •   Legal & Accounting

$90K - $110K *

Pioneer a unified marketing infrastructure by managing automation platforms, lead intelligence, and analytics. Collaborate with cross-functional teams to enhance data governance and optimize marketing...

United StatesRemote

3 days ago

  •   Less than 5 years exp.  •   Information Technology

$150K - $180K *

Advance global drug safety initiatives by leading pharmacovigilance activities, ensuring compliance with regulations, and collaborating with cross-functional teams to enhance product safety and operat...

United StatesRemote

3 days ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$87K - $157K *

Optimize compliance processes by leveraging your expertise in Medicare regulations. Collaborate with leadership to ensure adherence to CMS requirements, conduct risk assessments, and support audit rea...

RemoteRemote

Reposted 3 days ago

  •   5 - 7 years exp.  •   Healthcare

$143K - $194K *

Join a team that drives the execution of integrated media plans, ensuring compliance and operational excellence. Collaborate with cross-functional teams while enhancing brand strategies in healthcare...

United StatesRemote

Reposted 3 days ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$68K - $105K *

Transform your career by configuring and supporting Epic applications. Engage in systems analysis, design, and problem resolution while collaborating with end-users to enhance their experience and str...

RemoteRemote

3 days ago

  •   Less than 5 years exp.  •   Healthcare

$120K - $145K *

Join a team that shapes global regulatory strategy in a fast-paced environment. You will lead comprehensive regulatory plans, ensuring alignment and execution from development to post-marketing, impac...

United StatesRemote

Reposted 3 days ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$100K - $120K *

Join a team that's focused on driving partner growth in the travel industry. Leverage your expertise to build relationships, implement strategic plans, and engage clients, all while thriving in a coll...

United StatesRemote

3 days ago

  •   Less than 5 years exp.  •   Finance & Insurance

$88K - $105K *

Drive operational excellence by owning the Professional Services intake and workflow governance processes, ensuring efficient request management and seamless team collaboration to enhance service deli...

United StatesRemote

3 days ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$90K - $110K *

Shape the future of talent acquisition by managing end-to-end recruitment processes, collaborating with cross-functional teams, and optimizing hiring strategies to attract top talent in a fast-paced e...

United StatesRemote

3 days ago

  •   5 - 7 years exp.  •   Transportation

$80K - $95K *

Analyze product support for HSA and FSRA offerings, managing deployment, education, and communication. Collaborate with diverse teams to enhance customer experience and drive product effectiveness in...

3 days ago

  •   Less than 5 years exp.  •   Finance & Insurance

$100K - $120K *

Engage with government agencies to drive revenue through strategic partnerships. Cultivate relationships, identify opportunities, and execute sales strategies to meet growth objectives in the Intellig...

United StatesRemote

3 days ago

  •   5 - 7 years exp.  •   Transportation

$131K - $237K *

Unlock potential by driving business growth in the cruise missile sector, engaging with U.S. Navy and Marine Corps stakeholders to identify and capture new opportunities while collaborating with cross...

United StatesRemote

3 days ago

  •   8 - 10 years exp.  •   Technical Services

$100K - $231K *

Drive innovation in clinical decision support by leading the development of an AI-powered insights platform. Collaborate with cross-functional teams to transform complex data into actionable solutions...

RemoteRemote

Reposted 3 days ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$88K - $105K *

Join a team that's shaping competitive electrical bids, ensuring alignment with customer needs and organizational standards while enhancing the customer experience across our electrification division...

United StatesRemote

Reposted 3 days ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$135K - $176K *

Oversee and develop a pharmacy team to deliver exceptional patient care, ensuring compliance with regulations and promoting best practices while fostering a culture of excellence and collaboration wit...

3 days ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$185K - $344K *

Join a dynamic team driving strategic planning and performance management across analytics capabilities. Lead portfolio governance and execution initiatives to align resources and priorities, ensuring...

United StatesRemote

3 days ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$90K - $113K *

Lead strategic initiatives to enhance advocacy for California's children and youth. Collaborate with stakeholders, manage programs, and drive fundraising efforts to ensure impactful policy changes and...

United StatesRemote

3 days ago

  •   5 - 7 years exp.  •   Education, Government & Non-Profit

$90K - $110K *

Lead the charge in developing high-performing sales teams while mastering our sales system. This role combines personal sales excellence with training and mentoring, ensuring both individual and team...

3 days ago

  •   Less than 5 years exp.  •   Finance & Insurance

$90K - $110K *

Drive end-to-end payroll processes across multiple entities, ensuring accuracy and compliance. Manage domestic and international payroll, tax setups, and employee inquiries while building scalable sys...

United StatesRemote

3 days ago

  •   5 - 7 years exp.  •   Information Technology

$81K - $136K *

Join a team that's pioneering innovative radar and surveillance solutions. Lead proposal management and program execution, ensuring high-quality submissions while collaborating across functions to dri...

United StatesRemote

3 days ago

  •   5 - 7 years exp.  •   Information Technology

$150K - $180K *

Lead the charge in managing a technical team focused on Gitaly, driving performance, scalability, and maintainability while fostering a culture of accountability and ownership across distributed teams...

RemoteRemote

3 days ago

  •   Less than 5 years exp.  •   Information Technology

$125K - $150K *

Shape the future of financial modelling by leading a dynamic team responsible for analyzing and auditing complex financial models, ensuring reliability, and driving growth within a collaborative envir...

United StatesRemote

Reposted 3 days ago

  •   Less than 5 years exp.  •   Finance & Insurance

$131K - $197K *

Lead strategic initiatives in workforce management, optimizing resources and enhancing service experience across multi-channel contact centers while leveraging AI and automation for improved performan...

Reposted 3 days ago

  •   5 - 7 years exp.  •   Hospitals & Medical Centers

$148K - $313K *

Unlock potential by serving as a strategic advisor to enterprise clients, guiding them in architecting AI-first solutions within the Life Sciences sector, while driving internal initiatives and enhanc...

RemoteRemote

Reposted 3 days ago

  •   8 - 10 years exp.  •   Enterprise Technology

Frequently Asked Questions (FAQ)

  • Where can I find jobs paying $100,000 or more in Kentucky?question toggle

    Browse Ladders for vetted professional openings in Kentucky with salaries of $100,000 or more. Search by job title, employer, industry, or location to narrow your options.

  • What types of high-paying professional jobs are available in Kentucky?question toggle

    Opportunities may include leadership, healthcare administration, manufacturing, logistics, finance, technology, sales, and engineering roles. Availability and qualifications vary by employer and location.

  • Which Kentucky cities have professional job opportunities?question toggle

    Louisville and Lexington are major employment centers, and professional openings may also be available in other Kentucky communities. Check individual listings for the job location and work arrangement.

  • How can I improve my chances of getting a $100K+ job in Kentucky?question toggle

    Target roles that closely match your experience, tailor your resume to the job requirements, and emphasize measurable achievements, specialized expertise, and leadership impact.

  • Are all jobs listed in Kentucky remote or hybrid?question toggle

    Work arrangements vary by position and employer. Review each listing to see whether the role is onsite, hybrid, or remote.