Find professional opportunities across Iowa with salaries of $100,000 or more. From Des Moines and Cedar Rapids to Iowa City, Davenport, and beyond, Ladders helps experienced professionals discover vetted roles that match their skills and career goals.
Iowa employers hire experienced professionals in fields such as healthcare, technology, finance, engineering, manufacturing, insurance, and business leadership. Available positions and compensation vary by employer, location, and experience, so explore listings to see which opportunities fit your background.
Search jobs in major employment centers including Des Moines, Cedar Rapids, Iowa City, Davenport, and Sioux City, as well as remote and hybrid roles that may be available to candidates in Iowa. Use location and job-title filters to focus your search.
Compare responsibilities, qualifications, and compensation details across openings. Keep your resume current, tailor applications to each position, and set up job alerts to stay informed when relevant high-paying jobs are posted.
Ladders focuses on professional opportunities paying $100,000 or more. Browse Iowa listings to find your next career move and connect with roles suited to your expertise.
Average Salary: $110,075
Director, Business Development
$312K - $446K *
Lead a high-performing team to drive strategic growth in defense and intelligence markets. Oversee opportunity identification, partner engagement, and pipeline development, ensuring disciplined execut...
Today
$100K - $120K *
Transform patient care by overseeing pharmaceutical services, ensuring safe medication practices, and providing clinical support across diverse patient populations. Lead a team to enhance drug therapy...
Today
$80K - $95K *
Drive building performance and energy efficiency by conducting assessments, audits, and evaluations for diverse properties. Collaborate with clients to enhance sustainability and reduce operational co...
Today
$125K - $150K *
Drive channel sales success by defining and executing programs that recruit, activate, and grow Trusted Advisors. Collaborate across teams to enhance performance, communication, and operational effici...
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$130K - $200K *
Unlock potential by enhancing our data infrastructure. In this role, you'll own data pipelines, improve performance, and ensure reliable access to analytics across global markets, driving efficiency a...
Today
Security Architect / Security Engineer
$164K - $235K *
Shape the future of security architecture for agentic AI systems by creating and implementing robust, secure solutions that empower innovative applications and ensure data safety in a collaborative, f...
Reposted today
$159K - $287K *
Drive growth and lead strategic partnerships as you oversee P&L performance and business strategy for key global accounts, ensuring operational excellence and customer satisfaction while managing high...
Reposted today
$95K - $115K *
Transform the learner experience by owning business and functional requirements for custom LMS and LCMS platforms. Drive modernization and compliance while collaborating with cross-functional teams to...
Today
Head of Enterprise and Strategic Partnerships
$273K - $380K *
Take ownership of building innovative enterprise partnerships that embed financial solutions in leading platforms. Drive strategic deals, capitalize on your industry network, and structure first-of-a...
Reposted today
MarTech Delivery Lead - Manager
$87K - $316K *
Lead the charge in delivering innovative MarTech solutions, managing complex programs across global teams. Drive client success through strategic planning, risk management, and continuous improvement...
Today
Oracle HCM/Payroll Solution Architect Senior Manager/Associate Director
$116K - $140K *
Elevate your career as you architect transformative Oracle solutions, leading strategic discussions and designing scalable systems that drive measurable business value across HCM, AI, and industry cap...
Today
$80K - $95K *
Empower business success by collaborating with cross-functional teams to enhance operations, gather requirements, and implement IT solutions that align with strategic goals. Drive improvements in orde...
Reposted today
SAP Data Migration Senior Manager - CMT/SemiConductors
$132K - $302K *
Elevate enterprise data migration strategies for S/4HANA transformations. Lead complex projects, mentor teams, and engage with stakeholders to ensure data quality and successful execution across diver...
Today
$100K - $120K *
Shape the future of cloud applications by developing scalable modules and enhancing legacy systems. Collaborate with teams to ensure high-quality code and optimize performance within an Agile framewor...
Today
$118K - $140K *
Join a dynamic team to oversee the implementation and support of enterprise solutions, ensuring quality control and project management excellence while collaborating with clients on technical deployme...
Today
Director of Engineering, Advertiser Experience
$150K - $180K *
Empower engineering teams to innovate advertiser tools, driving technical strategy and delivery while enhancing user experience across self-service and managed workflows in a dynamic ad tech environme...
Today
Director, Field Medical Affairs (East)
$170K - $200K *
Lead and innovate within the Field Medical Affairs team, driving strategic alignment and operational excellence. Foster collaboration and scientific integrity while mentoring a high-performing team to...
Today
Director of Operational Finance
$160K - $170K *
Elevate your career by partnering with divisional leadership to drive financial strategy, enhance operational efficiency, and ensure accurate financial reporting within a dynamic SaaS environment. Mak...
Reposted today
Senior Product Marketing Manager, CPQ
$140K - $160K *
Empower sales teams by owning the go-to-market strategy for CPQ. Collaborate with product and sales leadership to define messaging, drive adoption, and enhance revenue operations through innovative ma...
Today
Sr. Manager, Revenue Management Services (Medicaid Operations)
$150K - $195K *
Join a team that's redefining Medicaid operations. Lead a high-performing team, drive compliance, and enhance rebate management processes while ensuring client satisfaction and operational excellence...
Today
Pharmacist | 40 hours per week | Inpatient Pharmacy
$131K *
Champion safe and effective pharmaceutical care by supervising pharmacy staff, developing clinical programs, and providing expert medication therapy consultations to enhance patient outcomes and suppo...
Today
Audio AI Research Scientist - Audio Source Separation
$165K - $227K *
Unlock your potential as you develop cutting-edge AI algorithms for real-time audio processing. Collaborate with experts to enhance audio experiences through innovative source separation techniques an...
Today
$80K - $100K *
Join a dynamic team to build lasting client relationships, oversee accounts, and deliver tailored pest management solutions. Leverage industry expertise and innovative tools to drive sales and ensure...
Today
Quantitative Model Validator, NLP and Gen AI/ Agentic AI
$100K - $196K *
Unlock potential by validating advanced NLP and AI models, ensuring compliance and performance. Collaborate across teams in a dynamic environment, leveraging your quantitative expertise to drive impac...
Today
$90K - $110K *
Empower clinical excellence by leading a team of Care Guide RNs while managing a caseload of active members. Drive performance, coaching, and quality metrics in a hybrid role that blends leadership wi...
Today
What kinds of $100,000+ jobs are available in Iowa?
Listings may include opportunities in healthcare, technology, finance, engineering, manufacturing, insurance, and business leadership. Roles and salary ranges vary by employer and experience.
Which Iowa cities have professional jobs listed?
Explore opportunities in Des Moines, Cedar Rapids, Iowa City, Davenport, Sioux City, and other Iowa locations. Remote or hybrid openings may also be available.
Are all jobs on this page guaranteed to pay at least $100,000?
Ladders focuses on professional jobs paying $100,000 or more, but compensation and eligibility can vary. Review each listing for its specific salary information and requirements.
How can I find the right high-paying job in Iowa?
Use filters for location, job title, and other preferences, then compare responsibilities and qualifications. Keeping your resume updated and setting job alerts can help you respond to relevant openings.