Explore $100K+ Jobs in Iowa

Find professional opportunities across Iowa with salaries of $100,000 or more. From Des Moines and Cedar Rapids to Iowa City, Davenport, and beyond, Ladders helps experienced professionals discover vetted roles that match their skills and career goals.

High-Paying Careers Across Iowa

Iowa employers hire experienced professionals in fields such as healthcare, technology, finance, engineering, manufacturing, insurance, and business leadership. Available positions and compensation vary by employer, location, and experience, so explore listings to see which opportunities fit your background.

Where to Find Iowa Opportunities

Search jobs in major employment centers including Des Moines, Cedar Rapids, Iowa City, Davenport, and Sioux City, as well as remote and hybrid roles that may be available to candidates in Iowa. Use location and job-title filters to focus your search.

Find a Role That Fits Your Experience

Compare responsibilities, qualifications, and compensation details across openings. Keep your resume current, tailor applications to each position, and set up job alerts to stay informed when relevant high-paying jobs are posted.

Search Vetted Professional Jobs on Ladders

Ladders focuses on professional opportunities paying $100,000 or more. Browse Iowa listings to find your next career move and connect with roles suited to your expertise.

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1,000+

Jobs in Iowa

Average Salary in USD

Average Salary: $110,075

Sort By: Relevance

$312K - $446K *

Lead a high-performing team to drive strategic growth in defense and intelligence markets. Oversee opportunity identification, partner engagement, and pipeline development, ensuring disciplined execut...

United StatesRemote

Today

  •   11 - 15 years exp.  •   Information Technology

$100K - $120K *

Transform patient care by overseeing pharmaceutical services, ensuring safe medication practices, and providing clinical support across diverse patient populations. Lead a team to enhance drug therapy...

Today

  •   Less than 5 years exp.  •   Healthcare

$80K - $95K *

Drive building performance and energy efficiency by conducting assessments, audits, and evaluations for diverse properties. Collaborate with clients to enhance sustainability and reduce operational co...

United StatesRemote

Today

  •   Less than 5 years exp.  •   Aerospace & Defense

$125K - $150K *

Drive channel sales success by defining and executing programs that recruit, activate, and grow Trusted Advisors. Collaborate across teams to enhance performance, communication, and operational effici...

United StatesRemote

Today

  •   8 - 10 years exp.  •   Finance & Insurance

$130K - $200K *

Unlock potential by enhancing our data infrastructure. In this role, you'll own data pipelines, improve performance, and ensure reliable access to analytics across global markets, driving efficiency a...

United StatesRemote

Today

  •   Less than 5 years exp.  •   Finance & Insurance

$164K - $235K *

Shape the future of security architecture for agentic AI systems by creating and implementing robust, secure solutions that empower innovative applications and ensure data safety in a collaborative, f...

United StatesRemote

Reposted today

  •   8 - 10 years exp.  •   Information Technology

$159K - $287K *

Drive growth and lead strategic partnerships as you oversee P&L performance and business strategy for key global accounts, ensuring operational excellence and customer satisfaction while managing high...

United StatesRemote

Reposted today

  •   8 - 10 years exp.  •   Consumer Technology

$95K - $115K *

Transform the learner experience by owning business and functional requirements for custom LMS and LCMS platforms. Drive modernization and compliance while collaborating with cross-functional teams to...

United StatesRemote

Today

  •   5 - 7 years exp.  •   Education, Government & Non-Profit

$273K - $380K *

Take ownership of building innovative enterprise partnerships that embed financial solutions in leading platforms. Drive strategic deals, capitalize on your industry network, and structure first-of-a...

United StatesRemote

Reposted today

  •   8 - 10 years exp.  •   Finance & Insurance

$87K - $316K *

Lead the charge in delivering innovative MarTech solutions, managing complex programs across global teams. Drive client success through strategic planning, risk management, and continuous improvement...

Today

  •   5 - 7 years exp.  •   Business Services

$116K - $140K *

Elevate your career as you architect transformative Oracle solutions, leading strategic discussions and designing scalable systems that drive measurable business value across HCM, AI, and industry cap...

Today

  •   8 - 10 years exp.  •   Business Services

$80K - $95K *

Empower business success by collaborating with cross-functional teams to enhance operations, gather requirements, and implement IT solutions that align with strategic goals. Drive improvements in orde...

United StatesRemote

Reposted today

  •   Less than 5 years exp.  •   Healthcare

$132K - $302K *

Elevate enterprise data migration strategies for S/4HANA transformations. Lead complex projects, mentor teams, and engage with stakeholders to ensure data quality and successful execution across diver...

Today

  •   8 - 10 years exp.  •   Business Services

$100K - $120K *

Shape the future of cloud applications by developing scalable modules and enhancing legacy systems. Collaborate with teams to ensure high-quality code and optimize performance within an Agile framewor...

United StatesRemote

Today

  •   Less than 5 years exp.  •   Information Technology

$118K - $140K *

Join a dynamic team to oversee the implementation and support of enterprise solutions, ensuring quality control and project management excellence while collaborating with clients on technical deployme...

United StatesRemote

Today

  •   Less than 5 years exp.  •   Consumer Technology

$150K - $180K *

Empower engineering teams to innovate advertiser tools, driving technical strategy and delivery while enhancing user experience across self-service and managed workflows in a dynamic ad tech environme...

United StatesRemote

Today

  •   5 - 7 years exp.  •   Technical Services

$170K - $200K *

Lead and innovate within the Field Medical Affairs team, driving strategic alignment and operational excellence. Foster collaboration and scientific integrity while mentoring a high-performing team to...

United StatesRemote

Today

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$160K - $170K *

Elevate your career by partnering with divisional leadership to drive financial strategy, enhance operational efficiency, and ensure accurate financial reporting within a dynamic SaaS environment. Mak...

United StatesRemote

Reposted today

  •   5 - 7 years exp.  •   Enterprise Technology

$140K - $160K *

Empower sales teams by owning the go-to-market strategy for CPQ. Collaborate with product and sales leadership to define messaging, drive adoption, and enhance revenue operations through innovative ma...

United StatesRemote

Today

  •   5 - 7 years exp.  •   Information Technology

$150K - $195K *

Join a team that's redefining Medicaid operations. Lead a high-performing team, drive compliance, and enhance rebate management processes while ensuring client satisfaction and operational excellence...

United StatesRemote

Today

  •   8 - 10 years exp.  •   Consumer Technology

$131K *

Champion safe and effective pharmaceutical care by supervising pharmacy staff, developing clinical programs, and providing expert medication therapy consultations to enhance patient outcomes and suppo...

Today

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$165K - $227K *

Unlock your potential as you develop cutting-edge AI algorithms for real-time audio processing. Collaborate with experts to enhance audio experiences through innovative source separation techniques an...

RemoteRemote

Today

  •   Less than 5 years exp.  •   Consumer Technology

$80K - $100K *

Join a dynamic team to build lasting client relationships, oversee accounts, and deliver tailored pest management solutions. Leverage industry expertise and innovative tools to drive sales and ensure...

Today

  •   Less than 5 years exp.  •   Staffing

$100K - $196K *

Unlock potential by validating advanced NLP and AI models, ensuring compliance and performance. Collaborate across teams in a dynamic environment, leveraging your quantitative expertise to drive impac...

Today

  •   Less than 5 years exp.  •   Finance & Insurance

$90K - $110K *

Empower clinical excellence by leading a team of Care Guide RNs while managing a caseload of active members. Drive performance, coaching, and quality metrics in a hybrid role that blends leadership wi...

United StatesRemote

Today

  •   5 - 7 years exp.  •   Healthcare

Frequently Asked Questions (FAQ)

  • What kinds of $100,000+ jobs are available in Iowa?question toggle

    Listings may include opportunities in healthcare, technology, finance, engineering, manufacturing, insurance, and business leadership. Roles and salary ranges vary by employer and experience.

  • Which Iowa cities have professional jobs listed?question toggle

    Explore opportunities in Des Moines, Cedar Rapids, Iowa City, Davenport, Sioux City, and other Iowa locations. Remote or hybrid openings may also be available.

  • Are all jobs on this page guaranteed to pay at least $100,000?question toggle

    Ladders focuses on professional jobs paying $100,000 or more, but compensation and eligibility can vary. Review each listing for its specific salary information and requirements.

  • How can I find the right high-paying job in Iowa?question toggle

    Use filters for location, job title, and other preferences, then compare responsibilities and qualifications. Keeping your resume updated and setting job alerts can help you respond to relevant openings.