Explore $100K+ Jobs in Iowa

Find professional opportunities across Iowa with salaries of $100,000 or more. From Des Moines and Cedar Rapids to Iowa City, Davenport, and beyond, Ladders helps experienced professionals discover vetted roles that match their skills and career goals.

High-Paying Careers Across Iowa

Iowa employers hire experienced professionals in fields such as healthcare, technology, finance, engineering, manufacturing, insurance, and business leadership. Available positions and compensation vary by employer, location, and experience, so explore listings to see which opportunities fit your background.

Where to Find Iowa Opportunities

Search jobs in major employment centers including Des Moines, Cedar Rapids, Iowa City, Davenport, and Sioux City, as well as remote and hybrid roles that may be available to candidates in Iowa. Use location and job-title filters to focus your search.

Find a Role That Fits Your Experience

Compare responsibilities, qualifications, and compensation details across openings. Keep your resume current, tailor applications to each position, and set up job alerts to stay informed when relevant high-paying jobs are posted.

Search Vetted Professional Jobs on Ladders

Ladders focuses on professional opportunities paying $100,000 or more. Browse Iowa listings to find your next career move and connect with roles suited to your expertise.

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1,000+

Jobs in Iowa

Average Salary in USD

Average Salary: $110,075

Sort By: Relevance

$110K - $130K *

Lead quality oversight for drug manufacturing, ensuring compliance with cGMPs. Collaborate with vendors on batch record review and product disposition for global clinical programs, thriving in a dynam...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$110K - $130K *

Elevate your career by joining a dynamic team focused on validating and optimizing Azure developer desktops. You'll design automated tests, ensure security compliance, and enhance performance metrics...

RemoteRemote

2 weeks ago

  •   5 - 7 years exp.  •   Enterprise Technology

$115K - $145K *

Optimize software development by owning complex features, leveraging AI tools, and collaborating with cross-functional teams to deliver high-quality, scalable solutions that meet business needs and te...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Enterprise Technology

$120K - $145K *

Innovate with us as you drive research initiatives, develop ML models, and translate complex algorithms into practical solutions, collaborating across teams to enhance fraud detection and authenticati...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Information Technology

$125K - $150K *

Advance your career by driving strategic vendor finance relationships in the industrial equipment sector. Lead business development efforts, manage key partnerships, and deliver tailored financing sol...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Legal & Accounting

$140K - $150K *

Reimagine the services landscape by optimizing the sales and delivery of professional services. In this influential role, collaborate cross-functionally to enhance proposal creation, streamline operat...

United StatesRemote

Reposted 2 weeks ago

  •   Less than 5 years exp.  •   Business Services

$110K - $130K *

Join a team that's transforming procurement operations through innovative strategies and data-driven solutions. Leverage your consulting expertise to enhance client outcomes and drive impactful change...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Business Services

$145K - $185K *

Empower healthcare organizations by leading service capture strategies, optimizing revenue integrity, and enhancing operational performance through strategic consulting and project management across d...

2 weeks ago

  •   5 - 7 years exp.  •   Business Services

$174K - $209K *

Lead the charge in optimizing distributed systems, ensuring performance and reliability for Mimir, a key telemetry database. Collaborate with a remote team to design, maintain, and enhance scalable so...

United StatesRemote

Reposted 2 weeks ago

  •   Less than 5 years exp.  •   Enterprise Technology

$100K - $120K *

Drive strategic oversight of enterprise-wide RAC audit activities, ensuring compliance and operational excellence. Collaborate with leadership to enhance audit processes, minimize financial risk, and...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$120K - $145K *

Drive system reliability and scalability as a Senior Site Reliability Engineer, focusing on automation and collaboration with software teams to enhance performance and maintain service objectives acro...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Finance & Insurance

$144K - $173K *

Transform finance operations by managing and optimizing the Netsuite ERP system, ensuring compliance and efficiency while collaborating with cross-functional teams to enhance business processes and dr...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Enterprise Technology

$145K - $182K *

Drive demand planning excellence by leading the Americas team, collaborating across functions to enhance forecasting accuracy and integrated business planning. Transform scenario planning capabilities...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Healthcare

$80K - $95K *

Support manufacturers by implementing solutions that enhance operational performance. Collaborate with teams to drive adoption and deliver measurable improvements, ensuring lasting value from the plat...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Manufacturing & Automotive

$130K - $216K *

Lead the technical implementation of a large-scale platform modernization program, ensuring adherence to architectural standards and providing hands-on guidance across multiple teams and vendors for s...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Business Services

$160K - $210K *

Collaborate with cross-functional teams to design and deliver full-stack features, enhancing code quality and mentoring junior engineers while owning projects from inception to deployment in a dynamic...

United StatesRemote

Reposted 2 weeks ago

  •   5 - 7 years exp.  •   Education, Government & Non-Profit

$120K - $185K *

Join a dynamic team as you design and develop CAD plugins, ensuring seamless integration with civil design workflows and GIS systems. Collaborate closely with engineers to enhance data management and...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Finance & Insurance

$125K - $150K *

Join a dynamic team to optimize supply chain operations, ensuring efficient medication delivery from pharmacy partners to patients. Oversee systems, processes, and a team to scale operations amidst ra...

United StatesRemote

Reposted 2 weeks ago

  •   8 - 10 years exp.  •   Healthcare

$80K - $93K *

Join a team that's dedicated to managing complex commercial liability claims. You'll negotiate settlements, investigate coverage, and ensure compliance while maintaining high standards in a fast-paced...

RemoteRemote

2 weeks ago

  •   Less than 5 years exp.  •   Finance & Insurance

$218K - $256K *

Empower our engineering teams by owning core developer infrastructure tools and systems. Drive strategic initiatives, enhance CI/build processes, and ensure reliability while mentoring engineers and s...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Finance & Insurance

$110K - $130K *

Join a dynamic team to lead the creation of impactful scientific content, enhancing medical education and patient outcomes. Collaborate cross-functionally, mentor writers, and drive excellence in heal...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$175K - $210K *

Transform the Platform organization by owning roadmap planning, development processes, and cross-functional coordination. Drive execution and ensure alignment with business goals while providing leade...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Finance & Insurance

$95K - $130K *

Manage the design and implementation of integrated physical security systems, driving innovative solutions in complex environments while fostering collaboration with clients and stakeholders for enhan...

United StatesRemote

Reposted 2 weeks ago

  •   5 - 7 years exp.  •   Technical Services

$100K - $166K *

Explore a rewarding leadership role mentoring engineers in electrical design for municipal water and wastewater projects. Drive technical success while fostering collaboration in a dynamic team dedica...

Reposted 2 weeks ago

  •   8 - 10 years exp.  •   Technical Services

$172K - $203K *

Empower the distribution strategy by designing and managing rate content across channels, ensuring accurate delivery and partner trust. Collaborate with cross-functional teams to build scalable progra...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Enterprise Technology

Frequently Asked Questions (FAQ)

  • What kinds of $100,000+ jobs are available in Iowa?question toggle

    Listings may include opportunities in healthcare, technology, finance, engineering, manufacturing, insurance, and business leadership. Roles and salary ranges vary by employer and experience.

  • Which Iowa cities have professional jobs listed?question toggle

    Explore opportunities in Des Moines, Cedar Rapids, Iowa City, Davenport, Sioux City, and other Iowa locations. Remote or hybrid openings may also be available.

  • Are all jobs on this page guaranteed to pay at least $100,000?question toggle

    Ladders focuses on professional jobs paying $100,000 or more, but compensation and eligibility can vary. Review each listing for its specific salary information and requirements.

  • How can I find the right high-paying job in Iowa?question toggle

    Use filters for location, job title, and other preferences, then compare responsibilities and qualifications. Keeping your resume updated and setting job alerts can help you respond to relevant openings.