Explore $100K+ Jobs in Iowa

Find professional opportunities across Iowa with salaries of $100,000 or more. From Des Moines and Cedar Rapids to Iowa City, Davenport, and beyond, Ladders helps experienced professionals discover vetted roles that match their skills and career goals.

High-Paying Careers Across Iowa

Iowa employers hire experienced professionals in fields such as healthcare, technology, finance, engineering, manufacturing, insurance, and business leadership. Available positions and compensation vary by employer, location, and experience, so explore listings to see which opportunities fit your background.

Where to Find Iowa Opportunities

Search jobs in major employment centers including Des Moines, Cedar Rapids, Iowa City, Davenport, and Sioux City, as well as remote and hybrid roles that may be available to candidates in Iowa. Use location and job-title filters to focus your search.

Find a Role That Fits Your Experience

Compare responsibilities, qualifications, and compensation details across openings. Keep your resume current, tailor applications to each position, and set up job alerts to stay informed when relevant high-paying jobs are posted.

Search Vetted Professional Jobs on Ladders

Ladders focuses on professional opportunities paying $100,000 or more. Browse Iowa listings to find your next career move and connect with roles suited to your expertise.

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1,000+

Jobs in Iowa

Average Salary in USD

Average Salary: $110,016

Sort By: Relevance

$89K - $104K *

Empower our customer community by developing and managing engagement strategies, enhancing brand reputation, and fostering influencer partnerships. Shape the future of our online presence while drivin...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Technical Services

$80K - $120K *

Unlock potential by driving impactful sales in the K-12 education sector. Engage with district leaders, manage complex sales cycles, and foster partnerships to enhance outcomes for English learners wh...

RemoteRemote

2 weeks ago

  •   Less than 5 years exp.  •   Education, Government & Non-Profit

$150K - $180K *

Join a transformative team as an Engineering Manager to lead engineering initiatives, inspire innovation, and drive technical excellence in revolutionizing healthcare technology while fostering profes...

RemoteRemote

Reposted 2 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$170K - $220K *

Transform program delivery by leading teams and managing client relationships. Drive strategic direction, ensure compliance, and achieve revenue goals while fostering a collaborative, remote-first env...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Healthcare

$120K - $145K *

Architect and enhance scalable infrastructure and CI/CD pipelines, collaborating across engineering teams to implement innovative cloud technologies and open-source solutions for optimal product deliv...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Information Technology

$110K - $130K *

Take ownership of our NetSuite environment by developing and automating solutions that enhance efficiency across Finance, Sales, and Operations. Collaborate with stakeholders to implement AI-driven fe...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Enterprise Technology

$150K - $180K *

Shape the future of security by leading our first dedicated security function. You'll build and execute a comprehensive security program, ensuring safe AI adoption while protecting sensitive health da...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Healthcare

$225K - $281K *

Lead detection and response strategy, building systems and automations to enhance security. Collaborate with teams to set standards, mentor engineers, and manage complex incidents, ensuring effective...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Enterprise Technology

$110K - $130K *

Join a dynamic team to define product strategy and deliver innovative payment solutions. Collaborate across functions to drive customer value and business outcomes while managing the end-to-end paymen...

RemoteRemote

2 weeks ago

  •   5 - 7 years exp.  •   Education, Government & Non-Profit

$160K - $192K *

Elevate cybersecurity solutions by driving revenue growth through strategic sales, managing the full sales lifecycle, and building strong relationships with clients and partners to enhance market pres...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Information Technology

$175K - $210K *

Lead the charge in developing impactful training strategies for rare disease therapies, collaborating with cross-functional teams to ensure alignment and readiness for commercial launches, while trans...

2 weeks ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$103K - $161K *

Drive strategic growth by establishing and nurturing key partnerships with Enterprise Claims carriers, ensuring service excellence and collaboration across internal teams to enhance business outcomes...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Finance & Insurance

$195K - $256K *

Elevate clinical quality assurance by designing and executing strategies for compliance, audit management, and oversight of global clinical operations. Collaborate with stakeholders to ensure adherenc...

United StatesRemote

2 weeks ago

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

$140K - $185K *

Elevate your career by managing a dynamic data engineering team, shaping scalable data pipelines, and driving innovative data solutions to enhance enterprise data strategies and execution efficiency a...

United StatesRemote

Reposted 2 weeks ago

  •   8 - 10 years exp.  •   Enterprise Technology

$80K - $100K *

Take ownership of complex desktop and mobile device support, ensuring high customer satisfaction. Administer enterprise management platforms and collaborate with teams to deliver effective technology...

RemoteRemote

2 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$80K - $95K *

Lead the end-to-end recruiting process, enhancing strategies and partnerships across departments. Drive high-volume hiring with autonomy, ensuring a seamless candidate experience while collaborating c...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Finance & Insurance

$126K - $254K *

Transform the public sector landscape by leading risk management and internal audit initiatives. Drive client success through strategic advisory, talent development, and innovative solutions while fos...

2 weeks ago

  •   8 - 10 years exp.  •   Finance & Insurance

$80K - $95K *

Drive analytical excellence by auditing freight contracts and invoices, ensuring compliance and accuracy. Collaborate with teams to enhance audit processes and mentor junior analysts, contributing to...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Business Services

$195K - $312K *

Zillow is seeking a Principal Applied Scientist to join the Agentic AI team, focusing on developing advanced multimodal technologies for understanding homes. The role involves designing and prototypin...

RemoteRemote

Reposted 2 weeks ago

  •   5 - 7 years exp.  •   Real Estate & Construction

$80K - $95K *

Contribute to the enhancement of our Quality Management System by leading ISO audits, ensuring compliance, and driving continuous improvement initiatives to elevate product quality and customer satisf...

2 weeks ago

  •   Less than 5 years exp.  •   Manufacturing & Automotive

$110K - $130K *

Join a team that's committed to environmental excellence, leading compliance for airport projects. Oversee assessments, manage permits, and ensure adherence to regulations while integrating sustainabi...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Staffing

$175K - $225K *

Transform data engineering practices by architecting scalable platforms, driving reliability, and mentoring teams. Lead cross-functional initiatives to enhance data governance and leverage AI tools fo...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Information Technology

$77K - $202K *

Drive impactful change in healthcare payer operations by analyzing complex challenges, managing workstreams, and guiding teams to enhance technology and service delivery models. Collaborate with clien...

2 weeks ago

  •   Less than 5 years exp.  •   Legal & Accounting

$118K - $236K *

Drive the product strategy for partner channel scheduling, collaborating with cross-functional teams to enhance user experience and operational efficiency in healthcare. Lead product development to en...

RemoteRemote

2 weeks ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$105K - $125K *

Lead technology operations for global teams, optimizing systems and support. Collaborate on strategic AI solutions, ensuring compliance and enhancing workflows. Drive efficiency and innovation in a dy...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Information Technology

Frequently Asked Questions (FAQ)

  • What kinds of $100,000+ jobs are available in Iowa?question toggle

    Listings may include opportunities in healthcare, technology, finance, engineering, manufacturing, insurance, and business leadership. Roles and salary ranges vary by employer and experience.

  • Which Iowa cities have professional jobs listed?question toggle

    Explore opportunities in Des Moines, Cedar Rapids, Iowa City, Davenport, Sioux City, and other Iowa locations. Remote or hybrid openings may also be available.

  • Are all jobs on this page guaranteed to pay at least $100,000?question toggle

    Ladders focuses on professional jobs paying $100,000 or more, but compensation and eligibility can vary. Review each listing for its specific salary information and requirements.

  • How can I find the right high-paying job in Iowa?question toggle

    Use filters for location, job title, and other preferences, then compare responsibilities and qualifications. Keeping your resume updated and setting job alerts can help you respond to relevant openings.