Explore $100K+ Jobs in Iowa

Find professional opportunities across Iowa with salaries of $100,000 or more. From Des Moines and Cedar Rapids to Iowa City, Davenport, and beyond, Ladders helps experienced professionals discover vetted roles that match their skills and career goals.

High-Paying Careers Across Iowa

Iowa employers hire experienced professionals in fields such as healthcare, technology, finance, engineering, manufacturing, insurance, and business leadership. Available positions and compensation vary by employer, location, and experience, so explore listings to see which opportunities fit your background.

Where to Find Iowa Opportunities

Search jobs in major employment centers including Des Moines, Cedar Rapids, Iowa City, Davenport, and Sioux City, as well as remote and hybrid roles that may be available to candidates in Iowa. Use location and job-title filters to focus your search.

Find a Role That Fits Your Experience

Compare responsibilities, qualifications, and compensation details across openings. Keep your resume current, tailor applications to each position, and set up job alerts to stay informed when relevant high-paying jobs are posted.

Search Vetted Professional Jobs on Ladders

Ladders focuses on professional opportunities paying $100,000 or more. Browse Iowa listings to find your next career move and connect with roles suited to your expertise.

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1,000+

Jobs in Iowa

Average Salary in USD

Average Salary: $110,033

Sort By: Relevance

$110K - $130K *

Join a team that's committed to enhancing environmental, health, and safety standards across multiple sites. Lead audits, provide hands-on support, and drive compliance initiatives while collaborating...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Finance & Insurance

$114K - $145K *

Champion the modernization and performance of enterprise applications, ensuring reliability and security while driving innovation and operational excellence in a remote leadership role focused on stra...

RemoteRemote

Reposted 1 week ago

  •   8 - 10 years exp.  •   Finance & Insurance

$120K - $130K *

Drive the design and implementation of complex software solutions, providing technical leadership and mentorship. Collaborate with cross-functional teams to enhance system architecture and ensure high...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Education, Government & Non-Profit

$95K - $105K *

Join a dynamic team to coordinate supplier management, drive contract workflows, and ensure compliance in clinical studies. Collaborate with cross-functional teams to enhance supplier processes and su...

RemoteRemote

1 week ago

  •   5 - 7 years exp.  •   Business Services

$160K - $180K *

Drive impactful regional marketing strategies that enhance customer engagement and pipeline growth across the Americas. Collaborate with global teams to create tailored campaigns and support sales ini...

United StatesRemote

1 week ago

  •   11 - 15 years exp.  •   Business Services

$110K - $130K *

Advance mechanical systems readiness by overseeing commissioning, conducting site inspections, and ensuring operational efficiency across critical infrastructure. Collaborate cross-functionally to enh...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Real Estate & Construction

$115K - $125K *

Drive the development and management of virtual health services, enhancing operational excellence and patient experience while scaling innovative care models across the organization. Lead strategic in...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Healthcare

$110K - $130K *

Accelerate progress at our organization by leading AI initiatives that transform business processes across departments, focusing on operational efficiency and measurable outcomes in Accounting and Fin...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Retail & Consumer Goods

$205K - $240K *

Elevate technology strategy and operations for North America's supply chain, leading engineering teams to optimize platforms and processes. Drive innovation in order management and logistics while ens...

United StatesRemote

Reposted 1 week ago

  •   8 - 10 years exp.  •   Retail & Consumer Goods

$107K - $204K *

Drive quality excellence by leading a team of assurance professionals, implementing strategic improvements, and collaborating across functions to enhance product quality and operational efficiency in...

1 week ago

  •   5 - 7 years exp.  •   Aerospace & Defense

$120K - $145K *

Transform application security practices by enhancing web, API, and cloud service protections. Collaborate with development teams to remediate vulnerabilities and integrate security into CI/CD workflo...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Finance & Insurance

$93K - $138K *

Join a team that's dedicated to enhancing operational efficiency through innovative software solutions. As a key contributor, you'll develop and maintain applications that streamline processes, ensuri...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Retail & Consumer Goods

$80K - $120K *

Engage clients by driving sales of Managed and Professional Services, identifying opportunities, and delivering tailored solutions. Cultivate relationships to exceed revenue targets while leveraging i...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Enterprise Technology

$135K - $160K *

Advance security integration by leading DevSecOps initiatives, enhancing software delivery, and establishing robust security standards across engineering teams to mitigate risks and improve efficiency...

RemoteRemote

1 week ago

  •   8 - 10 years exp.  •   Healthcare

$68K - $113K *

Lead project coordination efforts by ensuring effective communication and management of materials, schedules, and documentation. Collaborate with teams to streamline processes and enhance project effi...

United StatesRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Energy & Utilities

$110K - $130K *

Drive your career with a pivotal role in CMC regulatory affairs, ensuring compliance for biologics and small molecules. Collaborate across teams to prepare high-quality submissions and strategies, imp...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$104K - $174K *

Champion ecosystem growth by collaborating across teams to enhance partner operations, drive strategic initiatives, and optimize performance metrics, ensuring value delivery to customers and stakehold...

United StatesRemote

Reposted 1 week ago

  •   Less than 5 years exp.  •   Retail & Consumer Goods

$95K - $115K *

Join a team that's driving integration data migration strategies and analysis. Collaborate with project teams to execute and support data governance initiatives, ensuring quality and efficiency across...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Information Technology

$210K - $230K *

Accelerate progress at the forefront of clinical supply chain management, leading strategic initiatives to ensure seamless delivery of investigational products for global trials while collaborating ac...

United StatesRemote

1 week ago

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

$90K - $110K *

Champion strategic partnerships that drive growth and innovation. Leverage your sales expertise to enhance customer relationships and deliver tailored solutions, ensuring mutual success for both clien...

1 week ago

  •   8 - 10 years exp.  •   Food & Beverages

$73K - $102K *

Champion ERP solutions by collaborating with stakeholders to customize and integrate systems, ensuring alignment with business goals. Drive enhancements and maintain compliance while delivering effect...

RemoteRemote

1 week ago

  •   Less than 5 years exp.  •   Information Technology

$81K - $137K *

Unlock financial insights by leading complex accounting operations, ensuring accuracy in reporting, and collaborating with cross-functional teams to enhance processes and drive business decisions in a...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Real Estate & Construction

$160K - $190K *

Unlock your potential as you lead end-to-end design for complex AI-driven systems. Collaborate with cross-functional teams to create intuitive, secure user experiences that prioritize trust and precis...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Information Technology

$184K - $356K *

Innovate at the forefront of AI infrastructure validation by designing and implementing robust tooling for cluster readiness and certification, ensuring optimal performance for GPU deployments in prod...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Manufacturing & Automotive

$80K - $95K *

Transform healthcare initiatives by leading projects from inception to completion. Coordinate teams, manage timelines, and ensure clear communication to drive organizational priorities and deliver mea...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Healthcare

Frequently Asked Questions (FAQ)

  • What kinds of $100,000+ jobs are available in Iowa?question toggle

    Listings may include opportunities in healthcare, technology, finance, engineering, manufacturing, insurance, and business leadership. Roles and salary ranges vary by employer and experience.

  • Which Iowa cities have professional jobs listed?question toggle

    Explore opportunities in Des Moines, Cedar Rapids, Iowa City, Davenport, Sioux City, and other Iowa locations. Remote or hybrid openings may also be available.

  • Are all jobs on this page guaranteed to pay at least $100,000?question toggle

    Ladders focuses on professional jobs paying $100,000 or more, but compensation and eligibility can vary. Review each listing for its specific salary information and requirements.

  • How can I find the right high-paying job in Iowa?question toggle

    Use filters for location, job title, and other preferences, then compare responsibilities and qualifications. Keeping your resume updated and setting job alerts can help you respond to relevant openings.