Explore $100K+ Jobs in Iowa

Find professional opportunities across Iowa with salaries of $100,000 or more. From Des Moines and Cedar Rapids to Iowa City, Davenport, and beyond, Ladders helps experienced professionals discover vetted roles that match their skills and career goals.

High-Paying Careers Across Iowa

Iowa employers hire experienced professionals in fields such as healthcare, technology, finance, engineering, manufacturing, insurance, and business leadership. Available positions and compensation vary by employer, location, and experience, so explore listings to see which opportunities fit your background.

Where to Find Iowa Opportunities

Search jobs in major employment centers including Des Moines, Cedar Rapids, Iowa City, Davenport, and Sioux City, as well as remote and hybrid roles that may be available to candidates in Iowa. Use location and job-title filters to focus your search.

Find a Role That Fits Your Experience

Compare responsibilities, qualifications, and compensation details across openings. Keep your resume current, tailor applications to each position, and set up job alerts to stay informed when relevant high-paying jobs are posted.

Search Vetted Professional Jobs on Ladders

Ladders focuses on professional opportunities paying $100,000 or more. Browse Iowa listings to find your next career move and connect with roles suited to your expertise.

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1,000+

Jobs in Iowa

Average Salary in USD

Average Salary: $110,033

Sort By: Relevance

$200K - $270K *

Shape the future of immunotherapy by leading access strategies for a groundbreaking T-cell therapy. Collaborate with cross-functional teams to ensure timely payer engagement and coverage decisions, ma...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$238K - $280K *

Shape the future of AI/LLM security by leading innovative offensive strategies, defining technical vision, and driving cross-company initiatives to enhance NodeZero's capabilities in identifying and e...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Information Technology

$93K - $137K *

Join a dynamic team to enhance partner relationships, drive operational excellence, and foster business growth through strategic onboarding and support initiatives. Leverage your insurance expertise t...

RemoteRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Finance & Insurance

$78K - $100K *

Lead the end-to-end program management for enterprise clients in financial services, driving alignment and execution across cross-functional teams to achieve measurable business outcomes and ensure se...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Media

$138K - $165K *

Champion the development of LLM-powered applications and agentic systems. Drive complex use cases from ambiguous problems to production, ensuring high-quality and scalable AI solutions that address us...

RemoteRemote

Reposted 1 week ago

  •   Less than 5 years exp.  •   Information Technology

$236K - $325K *

Lead the charge in global security investigations and incident response, guiding complex incidents while building operational practices and technical capabilities to ensure effective responses across...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Finance & Insurance

$90K - $150K *

Drive underwriting excellence by managing property risks and building strong broker relationships. Collaborate with a dynamic team to deliver innovative solutions in a fully remote environment, focusi...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Finance & Insurance

$130K *

Drive innovation in healthcare technology by leading product management efforts, connecting cross-functional teams, and shaping the product roadmap to enhance value-based care solutions. Engage hands...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Finance & Insurance

$80K - $95K *

Shape the future of product design by developing innovative solutions from concept to production. Collaborate with cross-functional teams to ensure designs meet safety and quality standards while ment...

Reposted 1 week ago

  •   Less than 5 years exp.  •   Manufacturing & Automotive

$95K - $115K *

Join us to enhance enterprise infrastructure systems through innovative design and support. You'll oversee hybrid cloud and on-premises environments, ensuring security and compliance while driving mod...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Information Technology

$172K - $238K *

Lead and elevate secured lending asset quality and model oversight, shaping methodologies while collaborating with cross-functional teams to ensure rigorous governance and regulatory readiness for div...

United StatesRemote

Reposted 1 week ago

  •   8 - 10 years exp.  •   Finance & Insurance

$200K - $235K *

Lead the charge in advancing cancer research by building key relationships, executing impactful territory plans, and providing educational insights to healthcare professionals in Immuno-Oncology acros...

United StatesRemote

Reposted 1 week ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$125K - $150K *

Unlock insights as you analyze user data to shape strategy and product priorities. Collaborate with teams to create compelling narratives and dashboards that drive decision-making and enhance our unde...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Finance & Insurance

$119K - $144K *

Shape the future of organizational consulting by leading complex client engagements, transforming data into actionable insights, and influencing C-suite decisions while fostering team development and...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Consumer Technology

$125K - $145K *

Unlock potential by bridging IT policy and strategy with organizational goals. Manage policy governance for a federal CIO organization, ensuring alignment with federal standards and overseeing a compr...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Information Technology

$91K - $137K *

Empower your career by managing clinical research sites, ensuring patient safety, and maintaining data integrity. Collaborate with teams to oversee study implementation and monitoring, while enhancing...

United StatesRemote

Reposted 1 week ago

  •   Less than 5 years exp.  •   Healthcare

$181K - $225K *

Lead the charge in operationalizing complex clinical studies globally, collaborating with cross-functional teams to enhance proposal development and manage global lab relationships, ensuring strategic...

United StatesRemote

Reposted 1 week ago

  •   11 - 15 years exp.  •   Healthcare

$162K - $243K *

Shape the future of clinical research by leading cross-functional teams to optimize project delivery, ensuring quality and compliance while managing resources and budgets effectively across global cli...

United StatesRemote

Reposted 1 week ago

  •   8 - 10 years exp.  •   Healthcare

$100K - $120K *

Lead patient care initiatives as a Floating Registered Pharmacist across multiple locations, ensuring compliance with regulations, managing pharmacy operations, and fostering relationships with patien...

1 week ago

  •   Less than 5 years exp.  •   Retail & Consumer Goods

$85K - $105K *

Engage veterinary customers by leveraging consultative sales techniques to drive diagnostic revenue growth. Build strong relationships, educate staff, and collaborate with teams to deliver tailored so...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Healthcare

$80K - $95K *

Lead the charge in transforming veteran care through focused psychological evaluations. Join a collaborative clinical team to assess and support service members with timely and empathetic evaluations...

Reposted 1 week ago

  •   Less than 5 years exp.  •   Healthcare

$160K - $190K *

Elevate regulatory intelligence by translating complex changes into actionable insights, guiding product strategy and marketing efforts while establishing thought leadership and fostering relationship...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Enterprise Technology

$100K *

Empower senior living communities by driving measurable outcomes and adoption. Collaborate with care teams to enhance performance, ensuring impactful use of technology while fostering trusted relation...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$225K - $250K *

Engage with business owners navigating M&A transactions, providing integrated planning and support. Collaborate with deal teams to ensure seamless transitions and optimize after-tax outcomes during cr...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Finance & Insurance

$269K - $370K *

Join a team that's transforming AI into a measurable business capability. Lead strategic initiatives, optimize operations, and collaborate across functions to enhance AI adoption and efficiency while...

United StatesRemote

1 week ago

  •   11 - 15 years exp.  •   Information Technology

Frequently Asked Questions (FAQ)

  • What kinds of $100,000+ jobs are available in Iowa?question toggle

    Listings may include opportunities in healthcare, technology, finance, engineering, manufacturing, insurance, and business leadership. Roles and salary ranges vary by employer and experience.

  • Which Iowa cities have professional jobs listed?question toggle

    Explore opportunities in Des Moines, Cedar Rapids, Iowa City, Davenport, Sioux City, and other Iowa locations. Remote or hybrid openings may also be available.

  • Are all jobs on this page guaranteed to pay at least $100,000?question toggle

    Ladders focuses on professional jobs paying $100,000 or more, but compensation and eligibility can vary. Review each listing for its specific salary information and requirements.

  • How can I find the right high-paying job in Iowa?question toggle

    Use filters for location, job title, and other preferences, then compare responsibilities and qualifications. Keeping your resume updated and setting job alerts can help you respond to relevant openings.