Find professional opportunities across Iowa with salaries of $100,000 or more. From Des Moines and Cedar Rapids to Iowa City, Davenport, and beyond, Ladders helps experienced professionals discover vetted roles that match their skills and career goals.
Iowa employers hire experienced professionals in fields such as healthcare, technology, finance, engineering, manufacturing, insurance, and business leadership. Available positions and compensation vary by employer, location, and experience, so explore listings to see which opportunities fit your background.
Search jobs in major employment centers including Des Moines, Cedar Rapids, Iowa City, Davenport, and Sioux City, as well as remote and hybrid roles that may be available to candidates in Iowa. Use location and job-title filters to focus your search.
Compare responsibilities, qualifications, and compensation details across openings. Keep your resume current, tailor applications to each position, and set up job alerts to stay informed when relevant high-paying jobs are posted.
Ladders focuses on professional opportunities paying $100,000 or more. Browse Iowa listings to find your next career move and connect with roles suited to your expertise.
Average Salary: $110,033
National Access Director - West
$200K - $270K *
Shape the future of immunotherapy by leading access strategies for a groundbreaking T-cell therapy. Collaborate with cross-functional teams to ensure timely payer engagement and coverage decisions, ma...
1 week ago
Principal Attack Engineer, AI/LLM
$238K - $280K *
Shape the future of AI/LLM security by leading innovative offensive strategies, defining technical vision, and driving cross-company initiatives to enhance NodeZero's capabilities in identifying and e...
1 week ago
$93K - $137K *
Join a dynamic team to enhance partner relationships, drive operational excellence, and foster business growth through strategic onboarding and support initiatives. Leverage your insurance expertise t...
Reposted 1 week ago
$78K - $100K *
Lead the end-to-end program management for enterprise clients in financial services, driving alignment and execution across cross-functional teams to achieve measurable business outcomes and ensure se...
1 week ago
Senior AI Engineer with RAG and Agentic architectures
$138K - $165K *
Champion the development of LLM-powered applications and agentic systems. Drive complex use cases from ambiguous problems to production, ensuring high-quality and scalable AI solutions that address us...
Reposted 1 week ago
Senior Manager, Security Incident Response
$236K - $325K *
Lead the charge in global security investigations and incident response, guiding complex incidents while building operational practices and technical capabilities to ensure effective responses across...
1 week ago
$90K - $150K *
Drive underwriting excellence by managing property risks and building strong broker relationships. Collaborate with a dynamic team to deliver innovative solutions in a fully remote environment, focusi...
1 week ago
Senior Product Manager, Value-Based Care Platforms
$130K *
Drive innovation in healthcare technology by leading product management efforts, connecting cross-functional teams, and shaping the product roadmap to enhance value-based care solutions. Engage hands...
1 week ago
Research & Development - R&D Design Engineer 3
$80K - $95K *
Shape the future of product design by developing innovative solutions from concept to production. Collaborate with cross-functional teams to ensure designs meet safety and quality standards while ment...
Reposted 1 week ago
$95K - $115K *
Join us to enhance enterprise infrastructure systems through innovative design and support. You'll oversee hybrid cloud and on-premises environments, ensuring security and compliance while driving mod...
1 week ago
Senior Manager, Loan Salability & First-Line Model Governance
$172K - $238K *
Lead and elevate secured lending asset quality and model oversight, shaping methodologies while collaborating with cross-functional teams to ensure rigorous governance and regulatory readiness for div...
Reposted 1 week ago
Regional Medical Science Director (Northeast)
$200K - $235K *
Lead the charge in advancing cancer research by building key relationships, executing impactful territory plans, and providing educational insights to healthcare professionals in Immuno-Oncology acros...
Reposted 1 week ago
Startup Products Strategy & Operations, Insights & Analytics
$125K - $150K *
Unlock insights as you analyze user data to shape strategy and product priorities. Collaborate with teams to create compelling narratives and dashboards that drive decision-making and enhance our unde...
1 week ago
Strategic Advisor IV (Remote/Hybrid)
$119K - $144K *
Shape the future of organizational consulting by leading complex client engagements, transforming data into actionable insights, and influencing C-suite decisions while fostering team development and...
1 week ago
IT Policy and Strategy Planner
$125K - $145K *
Unlock potential by bridging IT policy and strategy with organizational goals. Manage policy governance for a federal CIO organization, ensuring alignment with federal standards and overseeing a compr...
1 week ago
Clinical Research Associate II - FSP
$91K - $137K *
Empower your career by managing clinical research sites, ensuring patient safety, and maintaining data integrity. Collaborate with teams to oversee study implementation and monitoring, while enhancing...
Reposted 1 week ago
Sr. Director, Scientific Affairs (Specialty Labs)
$181K - $225K *
Lead the charge in operationalizing complex clinical studies globally, collaborating with cross-functional teams to enhance proposal development and manage global lab relationships, ensuring strategic...
Reposted 1 week ago
$162K - $243K *
Shape the future of clinical research by leading cross-functional teams to optimize project delivery, ensuring quality and compliance while managing resources and budgets effectively across global cli...
Reposted 1 week ago
Floating Registered Pharmacist
$100K - $120K *
Lead patient care initiatives as a Floating Registered Pharmacist across multiple locations, ensuring compliance with regulations, managing pharmacy operations, and fostering relationships with patien...
1 week ago
Field Sales Veterinary Diagnostics Milwaukee South
$85K - $105K *
Engage veterinary customers by leveraging consultative sales techniques to drive diagnostic revenue growth. Build strong relationships, educate staff, and collaborate with teams to deliver tailored so...
1 week ago
Licensed Clinical Psychologist
$80K - $95K *
Lead the charge in transforming veteran care through focused psychological evaluations. Join a collaborative clinical team to assess and support service members with timely and empathetic evaluations...
Reposted 1 week ago
Senior Director, Regulatory & Industry Intelligence
$160K - $190K *
Elevate regulatory intelligence by translating complex changes into actionable insights, guiding product strategy and marketing efforts while establishing thought leadership and fostering relationship...
1 week ago
$100K *
Empower senior living communities by driving measurable outcomes and adoption. Collaborate with care teams to enhance performance, ensuring impactful use of technology while fostering trusted relation...
1 week ago
Director, Business Transitions
$225K - $250K *
Engage with business owners navigating M&A transactions, providing integrated planning and support. Collaborate with deal teams to ensure seamless transitions and optimize after-tax outcomes during cr...
1 week ago
Director, Internal AI Operations
$269K - $370K *
Join a team that's transforming AI into a measurable business capability. Lead strategic initiatives, optimize operations, and collaborate across functions to enhance AI adoption and efficiency while...
1 week ago
What kinds of $100,000+ jobs are available in Iowa?
Listings may include opportunities in healthcare, technology, finance, engineering, manufacturing, insurance, and business leadership. Roles and salary ranges vary by employer and experience.
Which Iowa cities have professional jobs listed?
Explore opportunities in Des Moines, Cedar Rapids, Iowa City, Davenport, Sioux City, and other Iowa locations. Remote or hybrid openings may also be available.
Are all jobs on this page guaranteed to pay at least $100,000?
Ladders focuses on professional jobs paying $100,000 or more, but compensation and eligibility can vary. Review each listing for its specific salary information and requirements.
How can I find the right high-paying job in Iowa?
Use filters for location, job title, and other preferences, then compare responsibilities and qualifications. Keeping your resume updated and setting job alerts can help you respond to relevant openings.