Explore $100K+ Jobs in Iowa

Find professional opportunities across Iowa with salaries of $100,000 or more. From Des Moines and Cedar Rapids to Iowa City, Davenport, and beyond, Ladders helps experienced professionals discover vetted roles that match their skills and career goals.

High-Paying Careers Across Iowa

Iowa employers hire experienced professionals in fields such as healthcare, technology, finance, engineering, manufacturing, insurance, and business leadership. Available positions and compensation vary by employer, location, and experience, so explore listings to see which opportunities fit your background.

Where to Find Iowa Opportunities

Search jobs in major employment centers including Des Moines, Cedar Rapids, Iowa City, Davenport, and Sioux City, as well as remote and hybrid roles that may be available to candidates in Iowa. Use location and job-title filters to focus your search.

Find a Role That Fits Your Experience

Compare responsibilities, qualifications, and compensation details across openings. Keep your resume current, tailor applications to each position, and set up job alerts to stay informed when relevant high-paying jobs are posted.

Search Vetted Professional Jobs on Ladders

Ladders focuses on professional opportunities paying $100,000 or more. Browse Iowa listings to find your next career move and connect with roles suited to your expertise.

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1,000+

Jobs in Iowa

Average Salary in USD

Average Salary: $110,033

Sort By: Relevance

$81K - $96K *

Drive the analysis and administration of complex rental housing projects, ensuring compliance with affordable housing programs while providing technical assistance and support to stakeholders througho...

5 days ago

  •   5 - 7 years exp.  •   Finance & Insurance

$79K - $112K *

Transform client relationships by leading participant communications strategies for large and not-for-profit markets. Drive engagement through multi-channel campaigns, ensuring client satisfaction and...

United StatesRemote

5 days ago

  •   5 - 7 years exp.  •   Finance & Insurance

$231K - $250K *

Transform your career by leading complex commercial transactions and providing strategic legal counsel. Collaborate with cross-functional teams to mitigate risks and enhance compliance while managing...

United StatesRemote

5 days ago

  •   11 - 15 years exp.  •   Business Services

$190K - $237K *

Lead the charge in developing strategic portfolio initiatives for oncology, driving cross-functional collaboration to enhance late-stage clinical development and market positioning through actionable...

United StatesRemote

5 days ago

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

$150K - $180K *

Join a team that's driving growth by managing strategic accounts and expanding relationships. You'll execute long-term sales strategies, engage stakeholders, and lead negotiations to enhance our marke...

United StatesRemote

5 days ago

  •   11 - 15 years exp.  •   Finance & Insurance

$66K - $99K *

Advance your nursing career by providing compassionate, individualized care to residents. Collaborate with a dedicated team to enhance patient outcomes in a supportive environment focused on professio...

5 days ago

  •   Less than 5 years exp.  •   Healthcare

$125K - $150K *

Join a team that's dedicated to transforming healthcare marketing. Lead cross-functional initiatives, provide strategic insights, and boost client success through innovative, data-driven campaigns in...

United StatesRemote

Reposted 5 days ago

  •   8 - 10 years exp.  •   Enterprise Technology

$119K - $186K *

Shape the future of CMC regulatory leadership by driving strategic initiatives, managing client projects, and mentoring teams to ensure excellence in delivery and business growth across complex health...

United StatesRemote

5 days ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$100K - $140K *

Lead the charge in architecting and building intelligent systems for autonomous GRC workflows, leveraging C#/.NET and Blazor to create scalable, high-performance solutions that drive innovation and ef...

United StatesRemote

5 days ago

  •   Less than 5 years exp.  •   Information Technology

$100K - $120K *

Drive new business growth by managing partner relationships and executing channel strategies. This role requires independent judgment to influence outcomes and achieve revenue targets through indirect...

United StatesRemote

5 days ago

  •   5 - 7 years exp.  •   Information Technology

$110K - $130K *

Transform sales performance by leading a team of quota-carrying representatives, driving disciplined pipeline management, and enhancing seller capabilities to achieve consistent revenue growth in a dy...

United StatesRemote

5 days ago

  •   8 - 10 years exp.  •   Media

$150K - $180K *

Elevate your skills in software and integration to drive impactful solutions across data engineering, AI functionality, application development, and DevOps, ensuring quality and innovation in every pr...

United StatesRemote

Reposted 5 days ago

  •   Less than 5 years exp.  •   Business Services

$95K - $115K *

Drive regional compliance initiatives and operational readiness by leading enforcement strategies, coordinating multi-agency operations, and enhancing training programs to ensure safety in hazardous m...

United StatesRemote

5 days ago

  •   Less than 5 years exp.  •   Energy & Utilities

$150K - $180K *

Lead and innovate compliance strategies to ensure adherence to ERISA, DOL, and IRS regulations. Drive technology-enabled solutions, manage risk, and enhance operational excellence while coaching compl...

United StatesRemote

5 days ago

  •   8 - 10 years exp.  •   Finance & Insurance

$78K - $88K *

Help us ensure compliance by reviewing and approving advertising materials, applying regulatory knowledge to mitigate risks, and guiding teams on standards to enhance quality and efficiency in marketi...

Reposted 5 days ago

  •   5 - 7 years exp.  •   Finance & Insurance

$160K - $180K *

Transform the future of cloud infrastructure by leading DevOps initiatives, enhancing systems integration, and driving innovative solutions for federal clients. Collaborate with stakeholders to optimi...

United StatesRemote

Reposted 5 days ago

  •   8 - 10 years exp.  •   Enterprise Technology

$69K - $125K *

Drive strategic development by assessing opportunities and creating reports. Collaborate with cross-functional teams to enhance governance and achieve organizational goals in a dynamic, remote environ...

United StatesRemote

Reposted 5 days ago

  •   Less than 5 years exp.  •   Healthcare

$107K - $204K *

Join a dynamic team as you lead integration and testing for cutting-edge embedded systems, ensuring robust verification and validation processes. Collaborate across disciplines to drive innovation and...

5 days ago

  •   5 - 7 years exp.  •   Aerospace & Defense

$105K - $177K *

Join a dynamic team as a Senior Price-to-Win Analyst, leveraging your analytical skills to drive strategic pricing recommendations and enhance competitive positioning in high-stakes federal pursuits...

United StatesRemote

5 days ago

  •   8 - 10 years exp.  •   Information Technology

$79K - $115K *

Engage with high-growth tech companies as you drive sales cycles, build relationships, and close cloud contracts. This fast-paced role requires a hunter mentality and the ability to connect with both...

United StatesRemote

5 days ago

  •   Less than 5 years exp.  •   Enterprise Technology

$155K - $170K *

Advance your career by leading compliance and risk initiatives in healthcare software. Drive SOC2 and HIPAA standards, engage with customers, and shape the future of compliance in a tech-forward envir...

United StatesRemote

5 days ago

  •   Less than 5 years exp.  •   Healthcare

$115K - $144K *

Empower your career by leading strategic marketing and sales initiatives across multiple communities, driving occupancy and revenue goals while collaborating with diverse teams to enhance brand positi...

5 days ago

  •   5 - 7 years exp.  •   Hospitals & Medical Centers

$150K - $188K *

Accelerate progress at achieving sales goals in oncology by driving product demand and executing launch plans. Collaborate with healthcare providers and internal teams to enhance patient care and ensu...

United StatesRemote

5 days ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$100K - $169K *

Drive impactful demand generation strategies for the Public Sector, collaborating cross-functionally to execute integrated marketing campaigns that enhance pipeline growth and revenue. Leverage data-d...

United StatesRemote

5 days ago

  •   5 - 7 years exp.  •   Enterprise Technology

$150K - $180K *

Transform the corporate internal audit landscape by shaping product strategy and developing AI-driven solutions that enhance efficiency and quality throughout the audit lifecycle, while collaborating...

United StatesRemote

5 days ago

  •   5 - 7 years exp.  •   Enterprise Technology

Frequently Asked Questions (FAQ)

  • What kinds of $100,000+ jobs are available in Iowa?question toggle

    Listings may include opportunities in healthcare, technology, finance, engineering, manufacturing, insurance, and business leadership. Roles and salary ranges vary by employer and experience.

  • Which Iowa cities have professional jobs listed?question toggle

    Explore opportunities in Des Moines, Cedar Rapids, Iowa City, Davenport, Sioux City, and other Iowa locations. Remote or hybrid openings may also be available.

  • Are all jobs on this page guaranteed to pay at least $100,000?question toggle

    Ladders focuses on professional jobs paying $100,000 or more, but compensation and eligibility can vary. Review each listing for its specific salary information and requirements.

  • How can I find the right high-paying job in Iowa?question toggle

    Use filters for location, job title, and other preferences, then compare responsibilities and qualifications. Keeping your resume updated and setting job alerts can help you respond to relevant openings.