Explore $100K+ Jobs in Iowa

Find professional opportunities across Iowa with salaries of $100,000 or more. From Des Moines and Cedar Rapids to Iowa City, Davenport, and beyond, Ladders helps experienced professionals discover vetted roles that match their skills and career goals.

High-Paying Careers Across Iowa

Iowa employers hire experienced professionals in fields such as healthcare, technology, finance, engineering, manufacturing, insurance, and business leadership. Available positions and compensation vary by employer, location, and experience, so explore listings to see which opportunities fit your background.

Where to Find Iowa Opportunities

Search jobs in major employment centers including Des Moines, Cedar Rapids, Iowa City, Davenport, and Sioux City, as well as remote and hybrid roles that may be available to candidates in Iowa. Use location and job-title filters to focus your search.

Find a Role That Fits Your Experience

Compare responsibilities, qualifications, and compensation details across openings. Keep your resume current, tailor applications to each position, and set up job alerts to stay informed when relevant high-paying jobs are posted.

Search Vetted Professional Jobs on Ladders

Ladders focuses on professional opportunities paying $100,000 or more. Browse Iowa listings to find your next career move and connect with roles suited to your expertise.

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1,000+

Jobs in Iowa

Average Salary in USD

Average Salary: $110,033

Sort By: Relevance

$110K - $130K *

Drive the design and execution of large-scale data centers, managing complex projects from initiation to construction. Oversee integrated schedules and governance, ensuring accountability while enabli...

RemoteRemote

Reposted 5 days ago

  •   5 - 7 years exp.  •   Enterprise Technology

$90K - $105K *

Elevate strategic communications for vaccine development, translating complex science into engaging narratives for diverse audiences while managing multiple priorities in a dynamic global health envir...

United StatesRemote

5 days ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$146K - $152K *

Collaborate with a multidisciplinary team to provide exceptional orthopedic care, supporting surgeries and patient management at a leading trauma center, while ensuring optimal outcomes and fostering...

Reposted 5 days ago

  •   Less than 5 years exp.  •   Healthcare

$175K - $250K *

Transform the GTM landscape by leading strategic initiatives, aligning teams, and driving measurable outcomes across solution areas. Foster collaboration and innovation to enhance sales processes and...

United StatesRemote

Reposted 5 days ago

  •   8 - 10 years exp.  •   Information Technology

$125K - $150K *

Join a team that's shaping the future of machine learning by leveraging traditional algorithms and financial data. Collaborate with clients to design, build, and optimize innovative solutions while ad...

Des Moines, IARemote

Reposted 5 days ago

  •   5 - 7 years exp.  •   Information Technology

$125K - $150K *

Elevate your career by leading strategic initiatives in enterprise systems. Drive operational excellence, enhance data integration, and champion modern processes to support institutional priorities an...

United StatesRemote

Reposted 5 days ago

  •   5 - 7 years exp.  •   Education, Government & Non-Profit

$153K - $171K *

Join a dynamic team to orchestrate complex technical programs, driving alignment and clarity across product and engineering. Empower teams to deliver impactful outcomes while leveraging AI insights fo...

United StatesRemote

5 days ago

  •   5 - 7 years exp.  •   Technical Services

$110K - $130K *

Unlock potential by leading operational excellence across Engineering teams, ensuring timely delivery and adherence to standards. Collaborate with cross-functional teams to drive accountability and en...

United StatesRemote

5 days ago

  •   5 - 7 years exp.  •   Finance & Insurance

$110K - $130K *

Shape the future of cybersecurity in higher education by delivering expert assessments, advisory services, and tailored remediation plans that empower institutions to enhance their security posture an...

United StatesRemote

Reposted 5 days ago

  •   Less than 5 years exp.  •   Education, Government & Non-Profit

$115K - $135K *

Lead the charge in developing high-quality software solutions, mentoring engineers, and driving process improvements. Collaborate with stakeholders to enhance systems and deliver impactful results in...

United StatesRemote

Reposted 5 days ago

  •   5 - 7 years exp.  •   Enterprise Technology

$200K - $250K *

Join us in shaping technical strategies and growth initiatives for federal opportunities. Collaborate across teams to develop compelling solutions that drive success in complex pursuits, ensuring alig...

United StatesRemote

Reposted 5 days ago

  •   8 - 10 years exp.  •   Enterprise Technology

$105K - $110K *

Drive innovation as a Software Engineer III, enhancing full-stack capabilities and mentoring junior developers while collaborating with stakeholders to improve engineering processes and deliver impact...

United StatesRemote

Reposted 5 days ago

  •   5 - 7 years exp.  •   Enterprise Technology

$110K - $130K *

Join a dynamic team as a Strategic Sales Engineer, driving sales growth through technical expertise and collaboration. Engage with sales leadership to create opportunities and deliver solutions across...

United StatesRemote

Reposted 5 days ago

  •   Less than 5 years exp.  •   Finance & Insurance

$70K - $205K *

Innovate digital laboratory operations by delivering strategic solutions that enhance scientific intelligence and user experiences, while collaborating with clients to transform their data-driven envi...

5 days ago

  •   Less than 5 years exp.  •   Business Services

$79K - $98K *

Drive statewide mine safety training initiatives by delivering MSHA courses, developing safety programs, and providing compliance support to operators. Engage with community colleges and industry part...

5 days ago

  •   Less than 5 years exp.  •   Education, Government & Non-Profit

$150K - $180K *

Optimize commercialization strategies for large-scale power solutions, focusing on data centers and hyperscalers. Lead deal origination, negotiate agreements, and collaborate with senior leaders to dr...

United StatesRemote

5 days ago

  •   8 - 10 years exp.  •   Energy & Utilities

$95K - $115K *

Drive your career with a role focused on designing and optimizing data pipelines and infrastructure. Collaborate with cross-functional teams to enhance data delivery and support the agency's mission t...

5 days ago

  •   Less than 5 years exp.  •   Education, Government & Non-Profit

$100K - $152K *

Engage in leading utility-scale power-system projects, overseeing all phases from planning to execution. Collaborate with multidisciplinary teams to ensure project delivery aligns with client expectat...

United StatesRemote

5 days ago

  •   5 - 7 years exp.  •   Technical Services

$80K - $95K *

Join a dynamic team as you drive revenue growth through virtual Finance & Insurance sales. Lead the full sales process, enhance customer experiences, and achieve performance targets in a fast-paced, r...

United StatesRemote

5 days ago

  •   Less than 5 years exp.  •   Manufacturing & Automotive

$108K - $130K *

Transform enterprise web application security by engineering and managing F5 WAF policies. Collaborate with cybersecurity teams to enhance protection, tune policies, and respond to incidents, ensuring...

United StatesRemote

5 days ago

  •   5 - 7 years exp.  •   Enterprise Technology

$85K - $100K *

Lead and inspire a dedicated nursing team, ensuring exceptional resident care and operational efficiency while fostering a culture of integrity and respect within a community-focused environment...

5 days ago

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$106K - $284K *

Lead the charge in designing and delivering secure, scalable microservices that enhance healthcare data exchange. Collaborate with cross-functional teams to ensure compliance and operational excellenc...

RemoteRemote

5 days ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$183K - $200K *

Shape the future of offensive security by leading advanced penetration testing, red-team engagements, and AI-assisted workflows. Collaborate with cross-functional teams to enhance security measures an...

United StatesRemote

5 days ago

  •   8 - 10 years exp.  •   Consumer Technology

$80K - $95K *

Transform building performance by conducting assessments and energy audits for diverse properties. Analyze systems, develop recommendations, and prepare reports to enhance efficiency and sustainabilit...

United StatesRemote

5 days ago

  •   Less than 5 years exp.  •   Aerospace & Defense

$145K - $175K *

Empower organizations to transform workflows with AI by architecting solutions that integrate Grok Build and Grok Bot. Collaborate with engineering teams and executives to drive adoption and optimize...

United StatesRemote

5 days ago

  •   Less than 5 years exp.  •   Information Technology

Frequently Asked Questions (FAQ)

  • What kinds of $100,000+ jobs are available in Iowa?question toggle

    Listings may include opportunities in healthcare, technology, finance, engineering, manufacturing, insurance, and business leadership. Roles and salary ranges vary by employer and experience.

  • Which Iowa cities have professional jobs listed?question toggle

    Explore opportunities in Des Moines, Cedar Rapids, Iowa City, Davenport, Sioux City, and other Iowa locations. Remote or hybrid openings may also be available.

  • Are all jobs on this page guaranteed to pay at least $100,000?question toggle

    Ladders focuses on professional jobs paying $100,000 or more, but compensation and eligibility can vary. Review each listing for its specific salary information and requirements.

  • How can I find the right high-paying job in Iowa?question toggle

    Use filters for location, job title, and other preferences, then compare responsibilities and qualifications. Keeping your resume updated and setting job alerts can help you respond to relevant openings.