Explore $100K+ Jobs in Iowa

Find professional opportunities across Iowa with salaries of $100,000 or more. From Des Moines and Cedar Rapids to Iowa City, Davenport, and beyond, Ladders helps experienced professionals discover vetted roles that match their skills and career goals.

High-Paying Careers Across Iowa

Iowa employers hire experienced professionals in fields such as healthcare, technology, finance, engineering, manufacturing, insurance, and business leadership. Available positions and compensation vary by employer, location, and experience, so explore listings to see which opportunities fit your background.

Where to Find Iowa Opportunities

Search jobs in major employment centers including Des Moines, Cedar Rapids, Iowa City, Davenport, and Sioux City, as well as remote and hybrid roles that may be available to candidates in Iowa. Use location and job-title filters to focus your search.

Find a Role That Fits Your Experience

Compare responsibilities, qualifications, and compensation details across openings. Keep your resume current, tailor applications to each position, and set up job alerts to stay informed when relevant high-paying jobs are posted.

Search Vetted Professional Jobs on Ladders

Ladders focuses on professional opportunities paying $100,000 or more. Browse Iowa listings to find your next career move and connect with roles suited to your expertise.

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1,000+

Jobs in Iowa

Average Salary in USD

Average Salary: $110,033

Sort By: Relevance

$87K - $95K *

Elevate patient care by assessing and treating diverse cases in a dynamic clinic. Collaborate with a skilled team, utilize advanced technology, and enjoy a supportive environment that fosters professi...

5 days ago

  •   Less than 5 years exp.  •   Healthcare

$130K - $170K *

Transform the future of genomics by driving strategic partnerships and large-scale research projects with pharmaceutical and biotech companies. Leverage your extensive network to identify opportunitie...

United StatesRemote

5 days ago

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

$110K - $130K *

Transform patient care as a vital pharmacist in a high-throughput environment. Collaborate with prescribers, verify prescriptions, and provide exceptional patient counseling to enhance outcomes and en...

United StatesRemote

5 days ago

  •   Less than 5 years exp.  •   Healthcare

$150K - $180K *

Join a team that's launching a federal vertical, setting strategy, winning agency customers, and building a sales team. You'll lead initial pursuits, collaborate with key stakeholders, and shape our a...

United StatesRemote

5 days ago

  •   8 - 10 years exp.  •   Legal & Accounting

$125K - $150K *

Shape the future of application operations by leading critical production services, ensuring reliability and governance across diverse platforms. Drive continuous improvement and operational excellenc...

5 days ago

  •   5 - 7 years exp.  •   Finance & Insurance

$110K - $130K *

Transform enterprise communications by leading the design, deployment, and support of Cisco UC Manager and SBC platforms. Collaborate with cross-functional teams to enhance network infrastructure and...

United StatesRemote

5 days ago

  •   Less than 5 years exp.  •   Enterprise Technology

$120K - $150K *

Empower labor relations across diverse construction projects by fostering strong partnerships with unions and project teams. Ensure compliance with agreements and resolve employee relations issues to...

RemoteRemote

5 days ago

  •   5 - 7 years exp.  •   Energy & Utilities

$175K - $210K *

Drive the enterprise data strategy and governance, ensuring data quality, compliance, and accessibility. Lead cross-functional teams to foster a data-rich culture, enabling advanced analytics and AI r...

United StatesRemote

Reposted 5 days ago

  •   8 - 10 years exp.  •   Healthcare

$80K - $95K *

Join a dynamic team as a Growth Copywriter, driving impactful messaging strategies through data-driven experimentation and empathetic communication to enhance women's health access and retention...

RemoteRemote

5 days ago

  •   5 - 7 years exp.  •   Healthcare

$83K - $124K *

Unlock insights and drive efficiency by providing analytical support to Business Development. Collaborate cross-functionally to enhance reporting, streamline processes, and ensure data integrity, empo...

United StatesRemote

5 days ago

  •   5 - 7 years exp.  •   Healthcare

$133K - $200K *

Accelerate clinical data management processes by leading data entry, ensuring quality, and overseeing database development for clinical trials. Collaborate with cross-functional teams to meet project...

United StatesRemote

5 days ago

  •   8 - 10 years exp.  •   Healthcare

$87K - $116K *

Join a team that's dedicated to guiding customers through their deployment journey, ensuring seamless transitions and successful outcomes. Leverage your expertise to manage complex projects and collab...

United StatesRemote

5 days ago

  •   Less than 5 years exp.  •   Information Technology

$144K - $206K *

Join a team that's shaping the future of event marketing by leading strategic initiatives, optimizing national events, and enhancing customer engagement through innovative programs and partnerships th...

United StatesRemote

5 days ago

  •   11 - 15 years exp.  •   Healthcare

$125K - $150K *

Lead the charge in optimizing healthcare payer systems by leveraging your expertise in Facets configuration and workflow analysis. Collaborate with cross-functional teams to design and implement scala...

United StatesRemote

5 days ago

  •   8 - 10 years exp.  •   Enterprise Technology

$78K - $118K *

Transform operational analytics by creating impactful performance metrics, diagnosing trends, and collaborating with cross-functional teams to optimize claims processes and drive continuous improvemen...

United StatesRemote

5 days ago

  •   Less than 5 years exp.  •   Finance & Insurance

$100K - $120K *

Accelerate progress at driving new-business growth through strategic channel partnerships. This role involves managing partner relationships, executing sales strategies, and influencing outcomes to ac...

United StatesRemote

5 days ago

  •   5 - 7 years exp.  •   Information Technology

$110K - $130K *

Join a team that's driving revenue growth by managing strategic corporate healthcare accounts, optimizing client satisfaction, and delivering measurable outcomes through expert relationship-building a...

United StatesRemote

5 days ago

  •   5 - 7 years exp.  •   Healthcare

$92K - $138K *

Empower your career by leading accounts receivable operations, optimizing cash flow, and enhancing team performance. Drive strategic initiatives, ensure compliance, and collaborate cross-functionally...

United StatesRemote

5 days ago

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$110K - $130K *

Lead the charge in managing complex technical projects across IT, Security, and Compliance. Engage with customers to translate technical needs into actionable plans while ensuring seamless internal co...

United StatesRemote

5 days ago

  •   5 - 7 years exp.  •   Enterprise Technology

$110K - $166K *

Lead the clinical data management process, ensuring quality and compliance from study startup to database lock. Collaborate with teams to develop databases, oversee data integrity, and train personnel...

United StatesRemote

5 days ago

  •   5 - 7 years exp.  •   Healthcare

$133K - $200K *

Drive excellence in clinical data management by overseeing data processes, ensuring quality, and leading cross-functional teams to deliver timely and accurate results throughout the clinical trial lif...

United StatesRemote

5 days ago

  •   8 - 10 years exp.  •   Healthcare

$80K - $95K *

Reimagine higher education processes by leveraging your expertise in Ellucian Colleague Registration and Records. Collaborate with institutions to enhance student enrollment services and optimize work...

United StatesRemote

Reposted 5 days ago

  •   Less than 5 years exp.  •   Education, Government & Non-Profit

$90K - $110K *

Drive success by partnering with colleges to optimize their Ellucian Colleague ERP systems, ensuring effective application design, configuration, and support while adhering to client budgets and timel...

United StatesRemote

Reposted 5 days ago

  •   Less than 5 years exp.  •   Education, Government & Non-Profit

$200K - $240K *

Innovate the future of legal support in a fast-paced environment, managing key commercial agreements and navigating regulatory challenges across various sectors. You'll drive legal strategy, enhance i...

United StatesRemote

Reposted 5 days ago

  •   5 - 7 years exp.  •   Technical Services

$225K - $305K *

Create a robust security compliance program that ensures customer trust and regulatory readiness. Lead a global team, design controls, manage audits, and integrate AI-driven solutions to address diver...

United StatesRemote

Reposted 5 days ago

  •   8 - 10 years exp.  •   Enterprise Technology

Frequently Asked Questions (FAQ)

  • What kinds of $100,000+ jobs are available in Iowa?question toggle

    Listings may include opportunities in healthcare, technology, finance, engineering, manufacturing, insurance, and business leadership. Roles and salary ranges vary by employer and experience.

  • Which Iowa cities have professional jobs listed?question toggle

    Explore opportunities in Des Moines, Cedar Rapids, Iowa City, Davenport, Sioux City, and other Iowa locations. Remote or hybrid openings may also be available.

  • Are all jobs on this page guaranteed to pay at least $100,000?question toggle

    Ladders focuses on professional jobs paying $100,000 or more, but compensation and eligibility can vary. Review each listing for its specific salary information and requirements.

  • How can I find the right high-paying job in Iowa?question toggle

    Use filters for location, job title, and other preferences, then compare responsibilities and qualifications. Keeping your resume updated and setting job alerts can help you respond to relevant openings.