Explore $100K+ Jobs in Iowa

Find professional opportunities across Iowa with salaries of $100,000 or more. From Des Moines and Cedar Rapids to Iowa City, Davenport, and beyond, Ladders helps experienced professionals discover vetted roles that match their skills and career goals.

High-Paying Careers Across Iowa

Iowa employers hire experienced professionals in fields such as healthcare, technology, finance, engineering, manufacturing, insurance, and business leadership. Available positions and compensation vary by employer, location, and experience, so explore listings to see which opportunities fit your background.

Where to Find Iowa Opportunities

Search jobs in major employment centers including Des Moines, Cedar Rapids, Iowa City, Davenport, and Sioux City, as well as remote and hybrid roles that may be available to candidates in Iowa. Use location and job-title filters to focus your search.

Find a Role That Fits Your Experience

Compare responsibilities, qualifications, and compensation details across openings. Keep your resume current, tailor applications to each position, and set up job alerts to stay informed when relevant high-paying jobs are posted.

Search Vetted Professional Jobs on Ladders

Ladders focuses on professional opportunities paying $100,000 or more. Browse Iowa listings to find your next career move and connect with roles suited to your expertise.

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1,000+

Jobs in Iowa

Average Salary in USD

Average Salary: $110,033

Sort By: Relevance

$180K - $225K *

Elevate the future of AI systems by architecting LLM-powered workflows that enhance customer interactions, ensuring security and performance while guiding teams through complex challenges and deliveri...

United StatesRemote

2 days ago

  •   5 - 7 years exp.  •   Business Services

$95K - $193K *

Elevate Paid Media strategies across a diverse portfolio, ensuring alignment with digital marketing goals. Lead investment management, agency collaboration, and performance oversight to drive impactfu...

United StatesRemote

2 days ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$110K - $130K *

Innovate and lead full-stack application development across diverse sectors, ensuring secure, scalable solutions. Collaborate with teams to transform concepts into market-ready products while establis...

United StatesRemote

2 days ago

  •   5 - 7 years exp.  •   Real Estate & Construction

$119K - $208K *

Explore an opportunity to lead security initiatives for a satellite broadband project. Drive the design and operation of PKI systems, ensuring compliance and security while collaborating with diverse...

United StatesRemote

Reposted 2 days ago

  •   5 - 7 years exp.  •   Retail & Consumer Goods

$80K - $95K *

Lead the charge in driving growth within the territory by building strong customer relationships, expanding key accounts, and delivering tailored water treatment solutions to meet complex challenges i...

United StatesRemote

2 days ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$130K - $155K *

Innovate and lead the development of a comprehensive IAM program, collaborating across teams to enhance identity governance and security. Manage a skilled team while ensuring compliance and effective...

United StatesRemote

2 days ago

  •   8 - 10 years exp.  •   Information Technology

$120K - $145K *

Elevate project delivery by managing multiple concurrent engagements, ensuring timely execution and quality. Collaborate with teams to drive client satisfaction and optimize resources while maintainin...

United StatesRemote

2 days ago

  •   8 - 10 years exp.  •   Enterprise Technology

$108K - $140K *

Unlock potential by leading verification and validation for regulated medical device software. Collaborate with cross-functional teams to ensure compliance and quality in bioinformatics and lab automa...

United StatesRemote

2 days ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$90K - $120K *

Transform your career by modernizing legacy applications and integrating AI solutions. Collaborate with cross-functional teams to design, develop, and enhance software that boosts efficiency and drive...

United StatesRemote

2 days ago

  •   5 - 7 years exp.  •   Enterprise Technology

$84K - $105K *

Engage with a dynamic Inside Sales Team, driving strategies to enhance customer acquisition and retention. Lead initiatives that maximize sales revenue and market share while fostering collaboration w...

United StatesRemote

2 days ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$95K - $115K *

Lead complex Logis Dispatch implementations from kickoff to handoff, ensuring dispatch centers go live smoothly. Collaborate with teams to configure systems, train users, and mentor consultants while...

United StatesRemote

2 days ago

  •   Less than 5 years exp.  •   Healthcare

$150K - $170K *

Drive strategic partnerships by leading growth initiatives, enhancing partner relationships, and executing annual strategies. Collaborate cross-functionally to optimize performance, improve satisfacti...

United StatesRemote

2 days ago

  •   8 - 10 years exp.  •   Healthcare

$144K - $220K *

Drive technical excellence as a Senior Staff Engineer, leading the Ops Portal team in shaping architecture and product direction across multiple platforms, while ensuring robust, scalable solutions fo...

United StatesRemote

2 days ago

  •   8 - 10 years exp.  •   Healthcare

$69K - $119K *

Elevate your career by managing diverse projects in healthcare, ensuring timely delivery and quality. Collaborate with teams to implement best practices, drive innovation, and enhance client experienc...

United StatesRemote

2 days ago

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$126K - $173K *

Drive integration strategies to enhance silicon photonic fabrication, collaborating with foundries to evolve processes from development to production while ensuring robust performance and reproducibil...

RemoteRemote

Reposted 2 days ago

  •   Less than 5 years exp.  •   Information Technology

$85K - $95K *

Champion data-driven insights by modernizing analytics through AI automation. Leverage SQL and BI tools to transform complex data into actionable reports, ensuring clarity and accuracy for leadership...

United StatesRemote

2 days ago

  •   Less than 5 years exp.  •   Media

$175K - $200K *

Join a dynamic team to manage strategic supplier partnerships, ensuring alignment with growth objectives and operational needs in a fast-paced cloud infrastructure environment. Drive collaboration and...

United StatesRemote

2 days ago

  •   8 - 10 years exp.  •   Information Technology

$188K - $235K *

Grow your career with a hands-on leadership role in GTM analytics, driving data-driven decisions across Sales, Marketing, and Customer Success. Shape analytics products and insights to enhance pipelin...

United StatesRemote

2 days ago

  •   8 - 10 years exp.  •   Enterprise Technology

$94K - $146K *

Transform cybersecurity by leading comprehensive penetration testing engagements, identifying vulnerabilities, and delivering actionable insights to clients while mentoring junior talent and advancing...

United StatesRemote

2 days ago

  •   Less than 5 years exp.  •   Legal & Accounting

$72K - $93K *

Transform patient care by delivering expert physical therapy in a dynamic skilled nursing environment. Collaborate with a dedicated team to enhance rehabilitation outcomes and support residents' recov...

2 days ago

  •   Less than 5 years exp.  •   Healthcare

$87K - $235K *

Accelerate operational excellence by leading supply chain improvements, managing client engagements, and driving performance management initiatives across logistics and distribution environments to ac...

Reposted 2 days ago

  •   5 - 7 years exp.  •   Business Services

$140K - $180K *

Shape the future of our Go-To-Market operations by owning and optimizing Salesforce. Collaborate with cross-functional teams to enhance sales processes, improve data quality, and drive efficiency acro...

United StatesRemote

2 days ago

  •   5 - 7 years exp.  •   Enterprise Technology

$135K - $180K *

Lead strategic HR initiatives across 600+ stores, enhancing leadership, talent development, and organizational effectiveness while driving regional performance and fostering an inclusive culture...

United StatesRemote

2 days ago

  •   8 - 10 years exp.  •   Retail & Consumer Goods

$145K - $170K *

Pioneer innovative research at the intersection of AI and cybersecurity, tackling real-world security challenges. Collaborate with diverse teams to develop prototypes and experiments that influence cu...

United StatesRemote

2 days ago

  •   Less than 5 years exp.  •   Information Technology

$93K - $123K *

Shape the future of regulatory submissions by coordinating U.S. FDA filings for investigational and commercial products. Collaborate with cross-functional teams to ensure timely, compliant submissions...

United StatesRemote

2 days ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

Frequently Asked Questions (FAQ)

  • What kinds of $100,000+ jobs are available in Iowa?question toggle

    Listings may include opportunities in healthcare, technology, finance, engineering, manufacturing, insurance, and business leadership. Roles and salary ranges vary by employer and experience.

  • Which Iowa cities have professional jobs listed?question toggle

    Explore opportunities in Des Moines, Cedar Rapids, Iowa City, Davenport, Sioux City, and other Iowa locations. Remote or hybrid openings may also be available.

  • Are all jobs on this page guaranteed to pay at least $100,000?question toggle

    Ladders focuses on professional jobs paying $100,000 or more, but compensation and eligibility can vary. Review each listing for its specific salary information and requirements.

  • How can I find the right high-paying job in Iowa?question toggle

    Use filters for location, job title, and other preferences, then compare responsibilities and qualifications. Keeping your resume updated and setting job alerts can help you respond to relevant openings.