Explore $100K+ Jobs in Iowa

Find professional opportunities across Iowa with salaries of $100,000 or more. From Des Moines and Cedar Rapids to Iowa City, Davenport, and beyond, Ladders helps experienced professionals discover vetted roles that match their skills and career goals.

High-Paying Careers Across Iowa

Iowa employers hire experienced professionals in fields such as healthcare, technology, finance, engineering, manufacturing, insurance, and business leadership. Available positions and compensation vary by employer, location, and experience, so explore listings to see which opportunities fit your background.

Where to Find Iowa Opportunities

Search jobs in major employment centers including Des Moines, Cedar Rapids, Iowa City, Davenport, and Sioux City, as well as remote and hybrid roles that may be available to candidates in Iowa. Use location and job-title filters to focus your search.

Find a Role That Fits Your Experience

Compare responsibilities, qualifications, and compensation details across openings. Keep your resume current, tailor applications to each position, and set up job alerts to stay informed when relevant high-paying jobs are posted.

Search Vetted Professional Jobs on Ladders

Ladders focuses on professional opportunities paying $100,000 or more. Browse Iowa listings to find your next career move and connect with roles suited to your expertise.

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1,000+

Jobs in Iowa

Average Salary in USD

Average Salary: $110,075

Sort By: Relevance

$94K - $146K *

Transform cybersecurity by leading comprehensive penetration testing engagements, identifying vulnerabilities, and delivering actionable insights to clients while mentoring junior talent and advancing...

United StatesRemote

Today

  •   Less than 5 years exp.  •   Legal & Accounting

$72K - $93K *

Transform patient care by delivering expert physical therapy in a dynamic skilled nursing environment. Collaborate with a dedicated team to enhance rehabilitation outcomes and support residents' recov...

Today

  •   Less than 5 years exp.  •   Healthcare

$87K - $235K *

Accelerate operational excellence by leading supply chain improvements, managing client engagements, and driving performance management initiatives across logistics and distribution environments to ac...

Reposted today

  •   5 - 7 years exp.  •   Business Services

$140K - $180K *

Shape the future of our Go-To-Market operations by owning and optimizing Salesforce. Collaborate with cross-functional teams to enhance sales processes, improve data quality, and drive efficiency acro...

United StatesRemote

Today

  •   5 - 7 years exp.  •   Enterprise Technology

$135K - $180K *

Lead strategic HR initiatives across 600+ stores, enhancing leadership, talent development, and organizational effectiveness while driving regional performance and fostering an inclusive culture...

United StatesRemote

Today

  •   8 - 10 years exp.  •   Retail & Consumer Goods

$145K - $170K *

Pioneer innovative research at the intersection of AI and cybersecurity, tackling real-world security challenges. Collaborate with diverse teams to develop prototypes and experiments that influence cu...

United StatesRemote

Today

  •   Less than 5 years exp.  •   Information Technology

$93K - $123K *

Shape the future of regulatory submissions by coordinating U.S. FDA filings for investigational and commercial products. Collaborate with cross-functional teams to ensure timely, compliant submissions...

United StatesRemote

Today

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$120K - $145K *

Engage with healthcare professionals to provide scientific insights on ADCT products. Develop relationships with KOLs and support medical affairs objectives while maintaining ethical standards in a dy...

United StatesRemote

Today

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$92K - $110K *

Provide comprehensive care to women and newborns during antenatal, intranasal, and postnatal periods, ensuring high-quality, culturally sensitive support while collaborating with healthcare teams to m...

Today

  •   Less than 5 years exp.  •   Healthcare

$135K - $155K *

Elevate your career by designing scalable healthcare data solutions. Collaborate with enterprise clients to uncover needs and guide architecture, ensuring alignment with best practices and regulatory...

United StatesRemote

Today

  •   8 - 10 years exp.  •   Healthcare

$81K - $103K *

Drive excellence in animal feed safety by conducting third-party audits, ensuring compliance with industry standards, and collaborating with audit teams to enhance certification processes and customer...

United StatesRemote

Today

  •   Less than 5 years exp.  •   Business Services

$95K - $115K *

Champion partner success by leading a dedicated team to enhance customer relationships, drive program delivery, and ensure operational excellence across educational assessments, fostering a culture of...

United StatesRemote

Today

  •   5 - 7 years exp.  •   Education, Government & Non-Profit

$230K - $290K *

Join a team that's dedicated to enhancing account security through innovative solutions. You'll lead technical strategies, collaborate across teams, and foster a culture of quality while ensuring seam...

United StatesRemote

Today

  •   8 - 10 years exp.  •   Finance & Insurance

$89K - $169K *

Lead the charge in managing complex client relationships, driving growth and retention through strategic planning and execution. Utilize expertise to implement customized service strategies and enhanc...

United StatesRemote

Today

  •   5 - 7 years exp.  •   Finance & Insurance

$76K - $158K *

Elevate your career by leading the administration and optimization of IBM Z-Series mainframe systems. Drive core business operations through technical expertise, mentoring, and continuous improvement...

Today

  •   5 - 7 years exp.  •   Finance & Insurance

$100K - $129K *

Drive your career with a Senior Network Administrator role, managing and optimizing enterprise network infrastructure. Collaborate across teams to ensure security, performance, and scalability while l...

United StatesRemote

Reposted today

  •   5 - 7 years exp.  •   Transportation

$88K - $105K *

Drive impactful sourcing projects by collaborating globally to optimize costs and quality. Leverage strong communication and project management skills to enhance supplier relationships and achieve str...

Today

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$72K - $90K *

Unlock potential by driving accurate project and cost accounting systems. Collaborate across departments to enhance financial insights, support decision-making, and ensure compliance with GAAP while m...

Reposted today

  •   5 - 7 years exp.  •   Staffing

$66K - $127K *

Shape the future of pharmaceutical marketing by leading PRC operations, ensuring compliance, and driving process improvements. Collaborate cross-functionally to enhance promotional material review and...

United StatesRemote

Today

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$185K *

Drive growth by leading a team of Strategic Account Managers to enhance enterprise account value through cross-sell and upsell strategies, fostering executive relationships and achieving expansion goa...

United StatesRemote

Today

  •   8 - 10 years exp.  •   Enterprise Technology

$100K - $120K *

Lead and manage medium-to-high complexity projects, ensuring successful delivery through effective communication, risk management, and collaboration with diverse teams using Agile and Waterfall method...

United StatesRemote

Today

  •   Less than 5 years exp.  •   Information Technology

$75K - $90K *

Optimize sourcing strategies and supplier relationships to drive value across regions. Lead negotiations, manage contracts, and collaborate with stakeholders to enhance procurement processes and maxim...

United StatesRemote

Today

  •   Less than 5 years exp.  •   Transportation

$74K - $112K *

Empower your career with a pivotal role in technical support, delivering expert troubleshooting for gas engine systems. Collaborate globally to resolve issues, enhance customer satisfaction, and drive...

United StatesRemote

Today

  •   5 - 7 years exp.  •   Energy & Utilities

$137K - $186K *

Unlock potential by leading cross-functional teams to deliver platform features that enhance global market capabilities. Drive localization efforts and ensure seamless integration across diverse regio...

RemoteRemote

Today

  •   5 - 7 years exp.  •   Legal & Accounting

$92K - $166K *

Join a team that's shaping the future of electric transmission design. Lead and mentor engineers while managing complex projects for major utilities. Drive innovation and quality in a dynamic, remote...

United StatesRemote

Today

  •   8 - 10 years exp.  •   Technical Services

Frequently Asked Questions (FAQ)

  • What kinds of $100,000+ jobs are available in Iowa?question toggle

    Listings may include opportunities in healthcare, technology, finance, engineering, manufacturing, insurance, and business leadership. Roles and salary ranges vary by employer and experience.

  • Which Iowa cities have professional jobs listed?question toggle

    Explore opportunities in Des Moines, Cedar Rapids, Iowa City, Davenport, Sioux City, and other Iowa locations. Remote or hybrid openings may also be available.

  • Are all jobs on this page guaranteed to pay at least $100,000?question toggle

    Ladders focuses on professional jobs paying $100,000 or more, but compensation and eligibility can vary. Review each listing for its specific salary information and requirements.

  • How can I find the right high-paying job in Iowa?question toggle

    Use filters for location, job title, and other preferences, then compare responsibilities and qualifications. Keeping your resume updated and setting job alerts can help you respond to relevant openings.