Information Systems Security Officer (ISSO) Jobs

Information Systems Security Officers help organizations protect sensitive data, systems, and networks. ISSOs assess security risks, guide teams through compliance requirements, and help ensure that information systems are designed and operated securely. Explore vetted ISSO opportunities on Ladders, including professional roles that pay $100,000 or more.

What Does an ISSO Do?

Responsibilities vary by employer and industry, but ISSOs commonly maintain security documentation, monitor system controls, coordinate risk assessments, and support authorization and compliance activities. They may work with system owners, security engineers, auditors, and government stakeholders to identify vulnerabilities and address findings.

Common ISSO Skills and Qualifications

Employers often seek experience in information security, risk management, security controls, and regulatory or government frameworks. Familiarity with standards such as NIST guidance, authorization processes, incident response, and security assessment practices can be valuable. Some roles require a bachelor’s degree, relevant certifications, security clearance, or experience supporting federal systems; requirements differ by position.

ISSO Career Opportunities

ISSO professionals work across government contracting, defense, technology, healthcare, financial services, and other sectors with complex security needs. Depending on experience, they may advance into senior ISSO, information assurance, cybersecurity program management, or security leadership roles. Browse current listings to compare responsibilities, qualifications, work arrangements, and compensation.

Find ISSO Jobs on Ladders

Use Ladders to explore vetted professional opportunities, including Information Systems Security Officer jobs with salaries of $100,000 or more. Review each listing for its specific pay range, location, clearance requirements, and experience expectations, then apply to roles aligned with your background.

Remote
caret down
Compensation
caret down
Position Level
caret down
Time Posted
caret down
Industries
caret down
More
1
caret down

$120K - $125K *

Unlock the potential of HRIS by optimizing Workday for seamless operations. Collaborate with cross-functional teams to enhance user experience, manage data security, and drive digital transformation w...

California, USRemote

1 week ago

  •   5 - 7 years exp.  •   Education, Government & Non-Profit

$110K - $130K *

Contribute to innovative solutions in the utility sector, supporting AMI projects through expert integration, mentoring, and alignment of technology with business needs. Champion industry standards an...

United StatesRemote

4 weeks ago

  •   5 - 7 years exp.  •   Business Services

$87K - $135K *

Unlock your potential by leading a dynamic Knowledge Management program that enhances IT support services, fosters collaboration, and drives efficiency for a large-scale enterprise environment. Make a...

United StatesRemote

3 days ago

  •   5 - 7 years exp.  •   Enterprise Technology

$90K - $189K *

Transform your career by leading a dynamic development team focusing on Oracle Fusion Cloud HCM extensions. Utilize cutting-edge technologies to support federal agencies in a collaborative, Agile envi...

RemoteRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Information Technology

$166K - $238K *

Lead a dynamic team of engineers in cloud operations, driving reliability and automation. Collaborate across departments to optimize performance and enhance mission-critical services for government cl...

Minneapolis, MNRemote

3 days ago

  •   8 - 10 years exp.  •   Telecommunications & Hardware

$120K - $140K *

Lead the charge in driving strategic business development efforts focused on Veterans Affairs and federal contracts, enhancing growth through relationship building and effective communication with key...

Rockville, MDRemote

1 week ago

  •   5 - 7 years exp.  •   Information Technology

$110K - $130K *

Engage in strategic partner ecosystem development to drive revenue growth and create innovative channel programs for sustained business success. Manage regional channel business and enhance existing p...

United StatesRemote

Reposted 2 weeks ago

  •   8 - 10 years exp.  •   Enterprise Technology

$80K - $134K *

Elevate compliance standards by conducting detailed FedRAMP assessments, analyzing technical artifacts, and collaborating with clients to ensure security controls are effectively implemented and docum...

United StatesRemote

Yesterday

  •   Less than 5 years exp.  •   Information Technology

$110K - $130K *

Elevate application security by driving best practices and collaborating with scrum teams. This role ensures data protection and compliance while integrating security into the software development lif...

Florida, USRemote

3 days ago

  •   Less than 5 years exp.  •   Finance & Insurance

$110K - $130K *

Shape the future of application security by driving best practices and collaborating with scrum teams to ensure data protection and secure development processes. Leverage your expertise to enhance our...

Pennsylvania, USRemote

3 days ago

  •   Less than 5 years exp.  •   Finance & Insurance

$130K - $155K *

Optimize security in Azure and Microsoft cloud environments at scale. Lead the design and implementation of robust architectures, leveraging AI tools to enhance security practices while collaborating...

Georgia, USRemote

2 weeks ago

  •   Less than 5 years exp.  •   Information Technology

$120K - $145K *

Lead the design and implementation of Moveworks AI solutions, integrating with ServiceNow to enhance enterprise workflows. Collaborate with teams to deliver innovative, scalable solutions that transfo...

United StatesRemote

3 days ago

  •   5 - 7 years exp.  •   Enterprise Technology

$238K - $311K *

Transform data governance by leading enterprise strategies, ensuring data quality, and driving AI readiness. Collaborate across teams to establish policies, enhance metadata platforms, and foster a cu...

RemoteRemote

1 week ago

  •   11 - 15 years exp.  •   Information Technology

$102K - $133K *

Unlock potential by optimizing clinical systems and driving informatics initiatives. This role combines strategy with hands-on support across EHR applications, fostering collaboration to enhance workf...

RemoteRemote

Reposted 2 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$89K - $148K *

Reimagine data integrity and performance through strategic testing of SAP systems. Collaborate with cross-functional teams to ensure seamless implementations, driving user acceptance and operational e...

United StatesRemote

4 weeks ago

  •   Less than 5 years exp.  •   Information Technology

$120K - $140K *

Join a team that's driving growth through strategic territory management and complex sales cycles. Leverage your expertise in cybersecurity to acquire new customers and expand existing accounts while...

Chicago, ILRemote

2 days ago

  •   5 - 7 years exp.  •   Information Technology

$110K - $130K *

Take ownership of technical solutions that enhance border security operations through data governance, cloud management, and infrastructure modernization. Collaborate across teams to drive effective I...

Ashburn, VARemote

1 week ago

  •   5 - 7 years exp.  •   Information Technology

$86K - $165K *

Join a dynamic team as a Software Developer, enhancing security tools through innovative web applications. Collaborate in an agile environment to design, develop, and maintain solutions that support c...

Texas, USRemote

2 weeks ago

  •   5 - 7 years exp.  •   Aerospace & Defense

$90K - $110K *

Drive the administration and enhancement of Nagios XI monitoring systems, ensuring optimal performance and coverage across diverse environments. Collaborate with IT teams to identify gaps and implemen...

Pennsylvania, USRemote

Today

  •   Less than 5 years exp.  •   Information Technology

$101K - $188K *

Elevate your career by enhancing platform reliability and automation. Collaborate with cross-functional teams to solve operational challenges, improve observability, and ensure dependable systems in a...

Connecticut, USRemote

2 weeks ago

  •   Less than 5 years exp.  •   Aerospace & Defense

$131K - $219K *

Join a team that's redefining cybersecurity in the energy sector. You'll lead complex projects, develop standards, and automate processes to enhance efficiency and security across global Grid Automati...

RemoteRemote

Today

  •   8 - 10 years exp.  •   Business Services

$125K - $150K *

Shape cybersecurity governance by leading risk assessment, strategy development, and cross-functional collaboration to enhance organizational security posture and mitigate emerging threats effectively...

Columbus, INRemote

Yesterday

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$65K - $98K *

Join a team that's dedicated to enhancing clinical documentation quality and coding accuracy. Collaborate with healthcare professionals to ensure comprehensive patient records and improve coding pract...

New York, NYRemote

Yesterday

  •   Less than 5 years exp.  •   Healthcare

$89K - $148K *

Shape the future of clinical documentation by leading a dynamic team to enhance integrity, performance, and compliance in healthcare settings, while collaborating with stakeholders to drive optimal re...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Business Services

$131K - $237K *

Lead the charge in managing complex IT programs, ensuring product development and lifecycle management while coordinating multiple vendors and teams to meet customer needs and deliver on strategic obj...

United StatesRemote

Yesterday

  •   8 - 10 years exp.  •   Technical Services

Frequently Asked Questions (FAQ)

  • What is an Information Systems Security Officer (ISSO)?question toggle

    An ISSO is a cybersecurity professional who helps protect an organization’s information systems by coordinating security controls, assessing risks, maintaining documentation, and supporting compliance and authorization activities.

  • What qualifications are commonly required for ISSO jobs?question toggle

    Requirements vary, but employers commonly look for information security or IT experience, knowledge of security controls and risk management, and familiarity with relevant standards such as NIST guidance. Some positions may require a degree, professional certifications, or an active security clearance.

  • How much do Information Systems Security Officers earn?question toggle

    Compensation varies by employer, location, experience, clearance, and job scope. Ladders focuses on vetted professional jobs paying $100,000 or more; check each listing for its stated salary or compensation details.

  • Where do ISSOs work?question toggle

    ISSO roles are found in government and defense contracting, technology, healthcare, financial services, and other industries that manage sensitive or regulated information.

  • How can I find ISSO jobs paying $100,000 or more?question toggle

    Browse Information Systems Security Officer listings on Ladders and review each posting’s compensation, qualifications, location, and clearance requirements to find roles that fit your experience.