Explore $100K+ Jobs in South Dakota

Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.

South Dakota career opportunities

South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.

Where to find jobs

Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.

Find the right role on Ladders

Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.

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1,000+

Healthcare Jobs in South Dakota

Average Salary in USD

Average Salary: $119,100

Sort By: Relevance

$130K - $190K *

Empower veterinary professionals by delivering expert dermatology advice and support, enhancing case management, and fostering strong relationships. Join a dynamic team committed to advancing veterina...

United StatesRemote

Reposted yesterday

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$76K - $89K *

Unlock potential by leading a dedicated team in delivering essential home visiting services. Oversee program implementation, ensure quality standards, and foster community partnerships to support fami...

Yesterday

  •   Less than 5 years exp.  •   Healthcare

$93K - $104K *

Join our team to provide exceptional nursing care across various settings. Enjoy flexible scheduling and competitive pay while making a difference in patients' lives through assessments, medication ad...

Yesterday

  •   Less than 5 years exp.  •   Healthcare

$93K - $104K *

Take ownership of patient care by delivering high-quality nursing services across various settings. Collaborate with healthcare teams to assess, document, and implement care plans while ensuring a saf...

Yesterday

  •   Less than 5 years exp.  •   Healthcare

$83K - $87K *

Transform patient care by providing essential nursing support in diverse settings. Enjoy flexible scheduling and competitive pay while making a meaningful impact in the lives of those you serve across...

Yesterday

  •   Less than 5 years exp.  •   Healthcare

$93K - $104K *

Transform patient care by providing essential nursing services across diverse settings. Enjoy flexible scheduling and competitive pay while making a meaningful impact in the lives of patients in vario...

Yesterday

  •   Less than 5 years exp.  •   Healthcare

$171K - $246K *

Shape the future of mental health care by providing remote psychiatric assessments and treatments. Deliver compassionate support to diverse clients, focusing on adults and adolescents, while collabora...

RemoteRemote

Reposted yesterday

  •   Less than 5 years exp.  •   Healthcare

$136K - $181K *

Take ownership of CRA management by leading teams, developing metrics, and ensuring compliance with monitoring standards. Drive continuous improvement and optimize effectiveness across the Site Manage...

United StatesRemote

Yesterday

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$74K - $111K *

Join a team that's dedicated to delivering exceptional service through timely maintenance and repairs of medical equipment, ensuring optimal healthcare delivery while enhancing customer satisfaction a...

RemoteRemote

Yesterday

  •   Less than 5 years exp.  •   Business Services

$102K - $153K *

Champion compliance and quality assurance in the Pharmaceutical Diagnostics sector. Drive audits, analyze trends, and support regulatory inspections to enhance operational excellence and ensure adhere...

United StatesRemote

Yesterday

  •   5 - 7 years exp.  •   Business Services

$92K - $138K *

Deliver clinical expertise and training support for XR products, enhancing customer experience and operational efficiency. Collaborate with sales and clinical teams to drive education initiatives and...

United StatesRemote

Yesterday

  •   Less than 5 years exp.  •   Business Services

$65K - $98K *

Engage with us to enhance healthcare by servicing and maintaining biomedical equipment. Utilize your technical expertise to ensure safety and reliability while fostering strong customer relationships...

United StatesRemote

Yesterday

  •   Less than 5 years exp.  •   Business Services

$77K - $116K *

Deliver exceptional service by diagnosing and repairing complex biomedical equipment, ensuring customer satisfaction through effective communication and proactive maintenance strategies. Collaborate w...

United StatesRemote

Yesterday

  •   Less than 5 years exp.  •   Business Services

$92K - $138K *

Join a dynamic team to deliver clinical education and support for diagnostic cardiology solutions, enhancing customer experience and driving successful outcomes through expert training and collaborati...

United StatesRemote

Yesterday

  •   Less than 5 years exp.  •   Business Services

$72K - $108K *

Contribute to customer satisfaction by performing timely Preventative Maintenance and assisting in troubleshooting and repairs of MRI equipment, while collaborating with experienced engineers to enhan...

United StatesRemote

Yesterday

  •   Less than 5 years exp.  •   Business Services

$76K - $114K *

Engage your technical expertise to deliver exceptional service and support for advanced surgical equipment. Collaborate with customers and teams to ensure satisfaction and compliance while driving ope...

United StatesRemote

Yesterday

  •   Less than 5 years exp.  •   Business Services

$110K - $130K *

Serve as a clinical and technical leader, influencing decision-makers and supporting product innovation in interventional healthcare. Engage with key stakeholders and showcase advanced solutions to en...

United StatesRemote

Yesterday

  •   5 - 7 years exp.  •   Business Services

$97K - $145K *

Lead strategic client coding integration initiatives, ensuring alignment with corporate objectives and regulatory compliance while driving operational excellence and innovation across the revenue cycl...

United StatesRemote

Reposted yesterday

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$83K - $87K *

Transform patient care by providing essential nursing support in diverse settings. Enjoy flexible scheduling and competitive pay while making a meaningful impact in long-term care and assisted living...

Yesterday

  •   Less than 5 years exp.  •   Healthcare

$95K - $115K *

Transform healthcare delivery by leveraging your Epic Cadence expertise to design, build, and optimize scheduling workflows. Collaborate with teams to ensure successful project outcomes and enhance pa...

United StatesRemote

Yesterday

  •   Less than 5 years exp.  •   Healthcare

$110K - $130K *

Unlock your potential as a senior Epic Willow Analyst, leading pharmacy workflow configurations and supporting clinical applications in a dynamic healthcare environment. Collaborate with teams to opti...

United StatesRemote

Yesterday

  •   Less than 5 years exp.  •   Healthcare

$63K - $96K *

Accelerate progress at the forefront of clinical technology, supporting multi-user systems and enhancing workflows. Collaborate with teams to optimize applications, ensuring effective use and continuo...

Yesterday

  •   Less than 5 years exp.  •   Healthcare

$67K - $100K *

Support patient care by delivering nursing services in a challenging behavioral health environment. Collaborate with a multidisciplinary team to provide critical medical and mental health care to elde...

Reposted yesterday

  •   Less than 5 years exp.  •   Healthcare

$64K - $96K *

Drive quality improvement initiatives by leveraging clinical expertise and data analytics. Collaborate with leaders to enhance patient outcomes and operational performance, ensuring compliance with re...

Reposted yesterday

  •   Less than 5 years exp.  •   Healthcare

$64K - $96K *

Empower patient care by delivering compassionate nursing services, developing care plans, and collaborating with healthcare teams to enhance patient outcomes and support families through their healthc...

Yesterday

  •   Less than 5 years exp.  •   Healthcare

Frequently Asked Questions (FAQ)

  • What types of $100,000-plus jobs are available in South Dakota?question toggle

    Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.

  • Which South Dakota cities have professional job opportunities?question toggle

    Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.

  • How can I find high-paying jobs in South Dakota?question toggle

    Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.

  • Do South Dakota jobs listed on Ladders all pay at least $100,000?question toggle

    Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.