Explore $100K+ Jobs in South Dakota

Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.

South Dakota career opportunities

South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.

Where to find jobs

Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.

Find the right role on Ladders

Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.

Remote
caret down
Compensation
caret down
Position Level
caret down
Time Posted
caret down
Industries
caret down
Locations
caret down
More
1
caret down
1,000+

Healthcare Jobs in South Dakota

Average Salary in USD

Average Salary: $119,100

Sort By: Relevance

$262K - $404K *

Optimize patient care and operational leadership as you manage Anesthesia APP teams, ensure regulatory compliance, and build strong client relationships while driving growth in practices and enhancing...

United StatesRemote

4 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$280K - $311K *

Optimize safety evaluations within our Drug Safety team to drive innovative strategies for monitoring and managing clinical risks, ensuring compliance and maintaining high-quality standards in pharmac...

United StatesRemote

4 weeks ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$88K - $149K *

Join a dynamic team in evaluating medication prior authorizations while developing clinical criteria and working closely with healthcare providers to ensure quality patient care through evidence-based...

RemoteRemote

4 weeks ago

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$108K - $180K *

Transform pharmacy services by driving strategic initiatives and cross-functional projects. Collaborate with stakeholders, analyze outcomes, and mentor team members while shaping the future of pharmac...

RemoteRemote

4 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$128K - $176K *

Drive clinical excellence and strategic medical affairs to enhance patient care through innovative product development, evidence generation, and cross-functional collaboration, ensuring compliance and...

RemoteRemote

Reposted 4 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$112K - $154K *

Lead the development and maintenance of Pharmacovigilance Risk Management Plans, ensuring pivotal safety documentation and compliance with global regulatory standards through collaboration and strong...

RemoteRemote

4 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$174K - $374K *

Engage with patients in their homes to conduct health evaluations, build relationships, and bridge care gaps. This role demands extensive travel and flexibility to provide personalized care and diagno...

United StatesRemote

4 weeks ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$80K - $95K *

Support patient evaluations by conducting psychological assessments and collaborating with a clinical team to enhance diagnostic outcomes and treatment plans. Leverage expertise in standardized testin...

United StatesRemote

4 weeks ago

  •   Less than 5 years exp.  •   Education, Government & Non-Profit

$73K - $108K *

Manage and deliver comprehensive physical therapy programs for diverse clients, conducting evaluations and interventions to enhance mobility, relieve pain, and improve strength. Collaborate with healt...

4 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$80K - $100K *

Transform the way we deliver mental health care to older adults through evidence-based teletherapy. Join a supportive team that prioritizes your autonomy and growth while you manage personalized treat...

South Dakota, USRemote

4 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$126K - $189K *

Join a team that's leading provider enrollment operations, ensuring timely onboarding, compliance, and accuracy. Drive strategic initiatives and enhance operational efficiency across networks while co...

United StatesRemote

4 weeks ago

  •   8 - 10 years exp.  •   Healthcare

$89K - $151K *

Deliver exceptional automation solutions that enhance operational efficiency and accuracy across the healthcare revenue cycle. Lead strategic initiatives to streamline processes, optimize performance...

United StatesRemote

4 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$76K - $96K *

Transform patient care by delivering compassionate, professional nursing services. Collaborate with interdisciplinary teams, utilize advanced clinical practices, and advocate for patients to ensure qu...

4 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$73K - $91K *

Lead compassionate patient care as a Registered Nurse, utilizing clinical expertise and teamwork to improve health outcomes. Engage with interdisciplinary teams to provide holistic support and quality...

4 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$108K - $196K *

Shape the future of healthcare by managing client relationships and optimizing clinical programs. Collaborate with teams to drive client success and ensure alignment with company goals, leveraging dat...

United StatesRemote

4 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$76K - $96K *

Discover a rewarding career as a Registered Nurse, where you'll deliver compassionate, quality care, collaborate with healthcare teams, and impact patients' lives through expert clinical practice and...

1 month ago

  •   5 - 7 years exp.  •   Healthcare

$145K - $195K *

Unlock patient engagement strategies by integrating insights into drug development. Collaborate with diverse teams to generate evidence, engage with professional societies, and lead initiatives that p...

United StatesRemote

1 month ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$100K - $120K *

Explore your future with NPs in Bloom, a community for Psychiatric Nurse Practitioners. Join us to be the first notified of openings in your state and nurture your career within a diverse, supportive...

United StatesRemote

1 month ago

  •   Less than 5 years exp.  •   Healthcare

$67K - $100K *

Transform patient care by coordinating services for kidney disease, ensuring optimal outcomes through collaboration across multidisciplinary teams and effective resource utilization...

1 month ago

  •   Less than 5 years exp.  •   Healthcare

$67K - $100K *

Join a team that's dedicated to delivering exceptional nursing care by evaluating patient needs, developing tailored care plans, and offering support to patients and families. Enjoy a collaborative, f...

1 month ago

  •   Less than 5 years exp.  •   Healthcare

$141K - $191K *

Lead the charge in developing high-impact scientific communications and engagement strategies, collaborating across teams to ensure compliance and compelling communication of clinical evidence to enha...

United StatesRemote

1 month ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$95K - $115K *

Contribute to the success of multiple clinical research sites by leading operations, ensuring compliance with regulations, and fostering team development to enhance patient care and operational excell...

United StatesRemote

Reposted 1 month ago

  •   5 - 7 years exp.  •   Healthcare

$141K - $191K *

Champion high-impact scientific communication strategies, collaborating across Medical Affairs and Commercial. Lead content development, enhance engagement, and drive operational excellence for effect...

United StatesRemote

1 month ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$268K - $466K *

Champion early clinical development in a dynamic team. Lead clinical research physician role for first-in-human studies, ensuring compliance and collaboration across scientific and regulatory areas to...

United StatesRemote

1 month ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$225K - $281K *

Join a team that's pushing the boundaries of oncology research! This key role involves designing and leading clinical trials, ensuring data integrity, and collaborating with global experts to advance...

United StatesRemote

1 month ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

Frequently Asked Questions (FAQ)

  • What types of $100,000-plus jobs are available in South Dakota?question toggle

    Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.

  • Which South Dakota cities have professional job opportunities?question toggle

    Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.

  • How can I find high-paying jobs in South Dakota?question toggle

    Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.

  • Do South Dakota jobs listed on Ladders all pay at least $100,000?question toggle

    Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.