Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.
South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.
Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.
Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.
Average Salary: $119,100
Associate Clinical Applications Specialist, Cardiology - Bracco Diagnostics Inc
$80K - $95K *
Unlock potential by providing expert support and training for Nuclear Medicine and PET customers, enhancing satisfaction and service quality for CardioGen-82 users through education, troubleshooting...
3 weeks ago
Registered Nurse (RN) | Emergency Unit
$67K - $100K *
Lead patient care by developing nursing diagnoses, coordinating interventions, and providing comprehensive support to patients and families. Collaborate with healthcare teams to ensure optimal health...
3 weeks ago
Head of Clinical Development, Pulse
$108K - $171K *
Join us to lead clinical development for an innovative AI cardiometabolic care solution. Collaborate cross-functionally to ensure clinical excellence in product features, workflows, and member experie...
3 weeks ago
Advanced Practice Provider - Pain Management
$90K - $110K *
Elevate patient care by managing complex cases in collaboration with healthcare teams. Utilize your expertise to assess, diagnose, and implement treatment plans, ensuring optimal outcomes in an outpat...
3 weeks ago
Vice President of Implementation
$297K - $367K *
Grow your career with a pivotal role driving hospital data integration and compliance. Lead execution of clinical data operations, build relationships, and ensure secure data handling while shaping a...
3 weeks ago
Assistant Director of Nursing (ADON) - RN - Full-Time
$72K - $93K *
Partner with us to enhance nursing leadership by guiding clinical practices, training staff, and ensuring compliance with regulations. Play a key role in delivering high-quality care and supporting a...
3 weeks ago
Healthcare Tech Manager - Epic Professional Billing
$130K - $150K *
Shape impactful healthcare solutions by leveraging your Epic Professional Billing expertise. Collaborate with diverse teams to optimize systems, enhance workflows, and drive meaningful results for cli...
3 weeks ago
Director, Specialty Clinical Solutions- REMOTE
$143K - $243K *
Champion innovative clinical strategies in specialty pharmacy, overseeing services and solutions to enhance client value and outcomes. Collaborate with cross-functional teams to drive program performa...
3 weeks ago
Senior Coding Compliance Auditor - Outpatient
$76K - $131K *
Join a team that's redefining healthcare compliance by leading detailed coding audits, mentoring auditors, and driving innovative solutions to enhance compliance and operational excellence in a dynami...
3 weeks ago
Senior Coding Compliance Auditor - Inpatient
$76K - $131K *
Elevate healthcare compliance by leading detailed coding audits, mentoring auditors, and implementing action plans. Drive innovation and ensure adherence to standards while fostering a culture of cont...
3 weeks ago
Internal Medicine or Family Medicine Physician
$241K - $337K *
Transform your career with a flexible role in primary care, serving a diverse patient population. Collaborate with a dedicated team in a supportive environment, offering both part-time and full-time o...
3 weeks ago
$68K - $105K *
Champion the implementation and support of Epic Beaker applications, ensuring effective system design, user experience, and problem resolution while managing projects and enhancing end-user engagement...
3 weeks ago
$195K - $277K *
Drive innovative clinical oncology studies by designing protocols, collaborating with teams, and ensuring compliance with regulations. Leverage expertise to analyze data, support publications, and mai...
3 weeks ago
$119K - $179K *
Support the integration and harmonization of clinical data by designing FHIR-compliant models and pipelines, ensuring data accuracy and usability for patient care and research initiatives across the o...
3 weeks ago
RN - Full Time PMs - SF Village
$70K - $99K *
Join a team that's dedicated to providing exceptional nursing care to residents. Utilize your expertise in assessment, planning, and implementation to enhance patient outcomes in a supportive long-ter...
Reposted 3 weeks ago
Principle Div Consultant- Medicare Provider Network Strategy - Remote
$92K - $167K *
Drive strategic initiatives in Medicare Advantage provider networks, analyzing data and collaborating with leadership to enhance performance and achieve goals. Lead complex projects from inception to...
3 weeks ago
Registered Nurse (RN) | Womens and Childrens Unit
$67K - $100K *
Champion patient care by delivering comprehensive nursing support through assessments, interventions, and education to enhance health outcomes and promote well-being across diverse settings...
Reposted 3 weeks ago
$164K - $273K *
Join a team that's advancing global scientific engagement through strategic conference planning and execution. Collaborate across functions to elevate medical affairs and enhance the impact of evidenc...
Reposted 3 weeks ago
Regional Account Manager, Payor Accounts - West Coast
$140K - $185K *
Accelerate progress at the forefront of payor relations, leading a team to develop strategic partnerships that enhance patient access and optimize reimbursement for innovative medical technologies in...
3 weeks ago
Senior Case Manager RN - Oncology (Remote)
$79K - $127K *
Partner with us to deliver comprehensive case management services, ensuring quality care and optimal health outcomes for members with complex needs. Collaborate with healthcare teams to develop and im...
3 weeks ago
$95K - $115K *
Transform patient care by delivering comprehensive primary health services, utilizing advanced practice skills to assess, diagnose, and treat diverse health conditions while collaborating with physici...
3 weeks ago
Clinical Informatics Specialist
$102K - $133K *
Unlock potential by optimizing clinical systems and driving informatics initiatives. This role combines strategy with hands-on support across EHR applications, fostering collaboration to enhance workf...
Reposted 3 weeks ago
National Accounts Director; Payor Accounts
$220K - $255K *
Shape the future of healthcare by leading strategic payor relationships and driving reimbursement strategies. Collaborate cross-functionally to enhance patient access and optimize coverage for innovat...
3 weeks ago
$92K - $138K *
Join our team to lead the Virtual Utilization Management Program, ensuring clinical excellence and operational efficiency. Collaborate with diverse healthcare professionals to enhance patient care and...
3 weeks ago
$152K - $202K *
Drive patient access by leveraging your expertise in reimbursement and market access. Collaborate with healthcare providers to navigate complex payer landscapes, ensuring timely access to therapies wh...
3 weeks ago
What types of $100,000-plus jobs are available in South Dakota?
Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.
Which South Dakota cities have professional job opportunities?
Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.
How can I find high-paying jobs in South Dakota?
Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.
Do South Dakota jobs listed on Ladders all pay at least $100,000?
Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.