Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.
South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.
Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.
Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.
Average Salary: $119,100
Associate Director, US Patient Advocacy
$164K - $225K *
Develop and execute patient advocacy strategies, engaging with PAOs and cross-functional teams to elevate the patient voice and ensure successful partnerships for rare disease therapeutic areas...
Reposted 1 week ago
$90K - $110K *
Analyze healthcare data to enhance clinical insights and improve medication use. Collaborate with cross-functional teams to develop analytics tools and real-world evidence studies, driving better heal...
1 week ago
Associate Director, Patient Recruitment and Retention Execution Manager
$194K - $266K *
Champion patient engagement strategies by leading a dynamic team focused on optimizing recruitment and retention across clinical trials. Drive performance, enhance collaboration, and ensure successful...
1 week ago
$84K - $99K *
Join a dynamic team to evaluate and process medication prior authorization requests, ensuring compliance with clinical guidelines and regulatory standards while facilitating timely patient access to n...
1 week ago
Quality Compliance & AI Operations Analyst
$80K - $90K *
Advance quality assurance initiatives and optimize workflows in a remote healthcare contact center. Collaborate cross-functionally to enhance compliance, improve patient outcomes, and drive continuous...
1 week ago
Full Time Remote Daytime Radiologist - Wilkes Barre-1
$250K - $300K *
Unlock your potential as a Diagnostic Radiologist, joining a respected practice with modern technology and a supportive team. Enjoy a balanced lifestyle while delivering exceptional patient care in a...
1 week ago
$210K - $250K *
Drive transformative healthcare initiatives by leading a team of practitioners, optimizing clinical protocols, and enhancing patient care through innovative medical solutions in weight management and...
1 week ago
$227K - $341K *
Lead the strategic development and continuous improvement of clinical programs, focusing on optimizing patient care across the continuum. Oversee a multidisciplinary team to enhance outcomes, reduce h...
1 week ago
Transformation Consultant, Digital Health
$85K - $137K *
Elevate healthcare transformation by coaching clinicians and leaders to optimize operational excellence and improve patient outcomes through effective EHR utilization and workflow redesign. Drive chan...
1 week ago
$193K - $241K *
Lead and oversee Medical Information teams, ensuring high-quality service delivery and compliance. Drive strategic initiatives, manage resources, and collaborate cross-functionally to enhance operatio...
1 week ago
Certified Medical Dosimetrist - Radiation (Remote)
$80K - $95K *
Shape the future of cancer treatment by collaborating with experts to create individualized radiation therapy plans. Leverage advanced tools and techniques in a supportive, fully remote environment fo...
1 week ago
Optometrist - Doctor of Optometry (Employee)
$200K *
Join a team that's dedicated to delivering exceptional eye care solutions while thriving in a dynamic, patient-centered environment. Utilize innovative technology to conduct comprehensive exams and cr...
1 week ago
Medical Affairs Technology and Digital Innovation Director
$190K - $238K *
Transform your career by leading the digital strategy for Medical Affairs. Drive innovation, optimize processes, and enhance scientific communications through emerging technologies while collaborating...
1 week ago
Senior Clinical Research Associate - Oncology
$105K - $140K *
Lead the charge in monitoring clinical study sites, ensuring data integrity and patient safety while collaborating with diverse teams to enhance study delivery and compliance with regulatory standards...
Reposted 1 week ago
$136K - $187K *
Lead patient education and support initiatives for individuals affected by generalized Myasthenia Gravis. Collaborate with caregivers and healthcare teams to enhance treatment coordination and empower...
1 week ago
$136K - $187K *
Join a team that's dedicated to empowering patients with generalized Myasthenia Gravis through education and support. As a key point of contact, you'll coordinate care, provide resources, and ensure c...
1 week ago
$136K - $187K *
Unlock potential by serving as a vital resource for patients and caregivers, providing education and support for managing generalized Myasthenia Gravis while coordinating treatment and navigating insu...
1 week ago
$168K - $231K *
Join a dynamic team to lead Nurse Case Managers, enhancing patient support and education throughout treatment journeys while ensuring compliance and quality in case management processes...
1 week ago
Regional Hospice RN (AZ/ CA/ NM)
$98K - $112K *
Join a dedicated team providing compassionate hospice care across multiple locations. Collaborate with interdisciplinary teams to ensure quality patient outcomes while adapting to diverse clinical env...
1 week ago
$142K - $168K *
Transform client experiences by leveraging deep expertise in healthcare solutions. Lead strategic initiatives, enhance client relationships, and drive impactful outcomes for high-value accounts throug...
1 week ago
Sys VP Clinical and Industry Trials
$180K - $220K *
Empower innovation in clinical trials by developing strategies, overseeing operations, and cultivating partnerships. Drive excellence in research, enhance compliance, and manage a high-performing team...
Reposted 1 week ago
Registered Nurse (RN) - $5k Bonus
$66K - $99K *
Unlock potential by providing compassionate care to individuals facing substance use and mental health challenges. Join a dedicated team committed to making a difference in the community through excep...
1 week ago
Director, Cost of Care Solutions
$129K - $162K *
Unlock potential by leading enterprise-wide Cost of Care solutions. Drive scalability, optimize deployment, and enhance operational effectiveness across diverse markets, collaborating with stakeholder...
Reposted 1 week ago
$95K - $115K *
Empower client success by leading technical implementations, ensuring data accuracy, and resolving complex challenges. Collaborate with cross-functional teams to enhance workflows and drive continuous...
1 week ago
Sr. Medical Science Liaison- Appalachia Region
$166K - $205K *
Elevate your career as a Senior Medical Science Liaison, driving scientific exchange and collaboration with healthcare providers in oncology. Build relationships, support clinical initiatives, and con...
1 week ago
What types of $100,000-plus jobs are available in South Dakota?
Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.
Which South Dakota cities have professional job opportunities?
Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.
How can I find high-paying jobs in South Dakota?
Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.
Do South Dakota jobs listed on Ladders all pay at least $100,000?
Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.