Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.
South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.
Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.
Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.
Director, Enterprise Operations, FP&A
$120K - $150K *
Transform supply chain financial management by leading cost analysis, budgeting, and strategic initiatives. Empower a cross-functional team to drive operational excellence and continuous improvement a...
1 week ago
$150K - $180K *
Lead the design and development of complex software systems, ensuring architectural consistency and best practices. Collaborate with teams to deliver scalable solutions while mentoring engineers and d...
1 week ago
Quality Control Specialist, Medical Writing
$74K - $99K *
Shape the future of regulatory submissions by ensuring high-quality QC reviews of clinical documents. Collaborate with global teams to meet project timelines while maintaining compliance with industry...
Reposted 1 week ago
$101K - $156K *
Elevate your career by configuring and enhancing Workday HCM solutions, driving user-centered processes and collaborating with stakeholders to deliver scalable, compliant solutions that support organi...
3 weeks ago
Rare Disease Account Specialist - Portland, OR
$135K - $186K *
Lead strategic initiatives in the Endocrine space, maximizing sales and building relationships with healthcare providers. Drive education and support for rare CAH disease management while ensuring eth...
1 week ago
Senior Project Manager, Promotional Medical Education
$90K - $100K *
Accelerate progress at a dynamic agency by leading complex client campaigns. Manage project scope, timelines, and budgets while collaborating with cross-functional teams to deliver high-quality result...
Reposted 1 week ago
$100K - $130K *
Transform healthcare by leading a dynamic PMO, ensuring program transparency and compliance across multiple customer accounts while fostering collaboration and continuous improvement...
2 days ago
Senior Director, Product Management, Agentic Platform
$192K - $303K *
Empower innovation as you lead the strategy and development of core platform primitives, driving the future of agentic systems and ensuring product teams can rapidly create and deploy advanced agents...
3 weeks ago
$75K - $125K *
Shape safety excellence by leading compliance initiatives in Process Safety Management. Collaborate with teams to implement and enhance safety programs, ensuring adherence to federal and state regulat...
Reposted today
Computer Systems Validation Engineer
$150K - $178K *
Pioneer a comprehensive Computer System Validation strategy across GxP systems. Collaborate with Quality and IT to drive compliance and data integrity while enhancing efficiency in validation processe...
Reposted 2 weeks ago
$91K - $115K *
Transform the candidate experience by sourcing top talent for sales and corporate roles. Collaborate with recruiters and hiring managers to build pipelines, utilizing advanced sourcing techniques and...
3 days ago
Sr. Account Executive, Enterprise
$112K - $150K *
Unlock potential by driving enterprise sales to Fortune 500 clients, managing end-to-end sales cycles, and fostering strategic relationships with C-level executives to deliver impactful SaaS complianc...
1 week ago
$150K - $180K *
Accelerate progress at driving revenue growth through strategic sales initiatives, building client relationships, and enhancing cybersecurity solutions for organizations, while managing the complete s...
Reposted 4 weeks ago
Site Reliability Engineering Team Lead (Principal SRE)
$150K - $180K *
Unlock potential by leading our Site Reliability Engineering team, ensuring the reliability and performance of our cloud-native platform. Drive technical excellence, cultivate a high-performance cultu...
Reposted 1 month ago
Commissioning Associate Director
$156K - $200K *
Champion the commissioning of hyperscale data centers by leading project teams, managing schedules, and ensuring compliance with technical standards. Collaborate with stakeholders to deliver successfu...
3 days ago
$155K - $210K *
Empower your career by leading enterprise database architecture and transformation initiatives. Collaborate with executive stakeholders to drive innovation and establish best practices in modern data...
3 weeks ago
$80K - $95K *
Elevate the patient admission process by leading a dynamic team, ensuring high-quality service, meeting quotas, and implementing best practices. This role is essential in connecting clients with criti...
Reposted 4 weeks ago
Senior Mortgage Loan Originator
$85K - $100K *
Grow your career with a dynamic team focused on residential mortgage origination. Lead initiatives to develop talent, manage loan processes, and ensure exceptional customer experiences while achieving...
1 week ago
Senior Engagement Manager - Medical Affairs
$210K - $258K *
Unlock your potential as a Senior Engagement Manager, leading complex consulting projects for pharmaceutical clients. Drive strategic medical initiatives, foster client relationships, and mentor teams...
Reposted 1 week ago
Senior Oncology Account Manager, Los Angeles North
$150K - $230K *
Lead the charge in oncology sales by building strong relationships with key stakeholders, driving product adoption, and ensuring patient access to innovative therapies. Collaborate with internal teams...
1 week ago
Senior Technical Consultant - Data & Analytics
$160K - $200K *
Lead the charge in designing and implementing scalable data solutions, orchestrating pipelines, and supporting advanced analytics in cloud environments. Collaborate with teams to deliver robust data a...
3 weeks ago
$110K - $130K *
Elevate client relationships by leading Client Success teams to ensure operational excellence, proactive issue resolution, and strategic growth, while fostering collaboration across departments to enh...
2 weeks ago
Director, Employer Sales - National Accounts
$349K - $396K *
Lead the charge in driving national growth strategies for enterprise employers, managing a top-performing sales team focused on Fortune 500 engagements, overseeing the acquisition lifecycle, and ensur...
Reposted 2 weeks ago
Lead Product Manager, Next Best Action Use Case Management
$126K - $173K *
Join a team that's redefining product management by owning the end-to-end strategy for Next Best Action. Collaborate with cross-functional teams to drive discovery, prioritize initiatives, and deliver...
3 days ago
Head of Clinical Development, Pulse
$108K - $171K *
Join us to lead clinical development for an innovative AI cardiometabolic care solution. Collaborate cross-functionally to ensure clinical excellence in product features, workflows, and member experie...
3 weeks ago
What types of $100,000-plus jobs are available in South Dakota?
Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.
Which South Dakota cities have professional job opportunities?
Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.
How can I find high-paying jobs in South Dakota?
Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.
Do South Dakota jobs listed on Ladders all pay at least $100,000?
Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.